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Tbio
PPP2R1B
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

Protein Summary
Description
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311129
  • ENSP00000311344
  • ENSG00000137713
  • ENST00000341980
  • ENSP00000343317
  • ENST00000393055
  • ENSP00000376775
  • ENST00000426998
  • ENSP00000410671
  • ENST00000527614
  • ENSP00000437193

Symbol
  • PR65B
  • PP2A-Abeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
disease perturbation
0.87
hub protein
0.85
kinase perturbation
0.76
tissue sample
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.24   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.24   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (360)
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.999999503
p_ni:  4.97e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.999977562
p_ni:  0.000022438
Score:  0.99
Data Source:  BioPlex,STRINGDB
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  0.999905622
p_ni:  0.000094378
Score:  0.999
Data Source:  BioPlex,STRINGDB
SERTAD4
Tdark
Novelty:  0.70786986
p_int:  0.99984004
p_ni:  0.00015996
Score:  0.68
Data Source:  BioPlex,STRINGDB
PPP2R3A
Tbio
Family:  Enzyme
Novelty:  0.0350873
p_int:  0.999534543
p_ni:  0.000465457
Score:  0.862
Data Source:  BioPlex,STRINGDB
FOXD4
Tbio
Family:  TF
Novelty:  0.11166611
p_int:  0.998905541
p_ni:  0.001094459
Data Source:  BioPlex
TBCCD1
Tbio
Novelty:  0.21991508
p_int:  0.998319443
p_ni:  0.001680557
Score:  0.219
Data Source:  BioPlex,STRINGDB
CDCA4
Tbio
Novelty:  0.04549061
p_int:  0.998251601
p_ni:  0.001748399
Score:  0.565
Data Source:  BioPlex,STRINGDB
PRR14
Tbio
Novelty:  0.22401806
p_int:  0.997789973
p_ni:  0.002210027
Data Source:  BioPlex
IER2
Tbio
Novelty:  0.03864806
p_int:  0.995483833
p_ni:  0.004516167
Score:  0.307
Data Source:  BioPlex,STRINGDB
Pathways (134)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

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Items per page:
1 – 5 of 112
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Reactome
Adaptive Immune System
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Adaptive Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
6
7
96.2
waist-hip ratio
2
5
5
93.4
BMI-adjusted waist circumference
1
6
6
92.6
waist circumference
1
5
5
92.1
self reported educational attainment
2
2
2
75
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
7
96.2
waist-hip ratio
5
93.4
BMI-adjusted waist circumference
6
92.6
waist circumference
5
92.1
self reported educational attainment
2
75
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IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 scaffold subunit Abeta
VGNC:10399
466778
Macaque
protein phosphatase 2 scaffold subunit Abeta
710387
Mouse
MGI:1920949
73699
Rat
RGD:1304764
315648
Dog
protein phosphatase 2 scaffold subunit Abeta
VGNC:44906
479444
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 scaffold subunit Abeta
Macaque
protein phosphatase 2 scaffold subunit Abeta
Mouse
Rat
Dog
protein phosphatase 2 scaffold subunit Abeta
Publication Statistics
PubMed Score 25.24
PubMed score by year
PubTator Score 20.12
PubTator score by year
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Related Publications
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PMID
Year
Title