Tbio PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Protein Summary

Description

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887). This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• P30153
• Q13773
• Q6ICQ3
• Q96DH3

Gene Name

• PPP2R1A

Ensembl ID

• ENST00000322088
• ENSP00000324804
• ENSG00000105568

Symbol

• MRD36
• PP2AA
• PR65A
• PP2AAALPHA
• PP2A-Aalpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
biological process	0.98
co-expressed gene	0.98
disease perturbation	0.96
interacting protein	0.92

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Serine/threonine-protein Phosphatase 2a 65 Kda Regulatory Subunit A Alpha Isoform

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Serine/threonine-protein Phosphatase 2a 65 Kda Regulatory Subunit A Alpha Isoform

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.46   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 359   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.46   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0