PDIA3
Protein disulfide-isomerase A3
Protein Summary
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016]
- ENST00000300289
- ENSP00000300289
- ENSG00000167004
- ERP57
- ERP60
- GRP58
- P58
- ER60
- ERp57
- ERp60
- ERp61
- GRP57
- GRP58
- PI-PLC
- HsT17083
- HEL-S-269
- HEL-S-93n
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
disease perturbation | 0.97 | ||
interacting protein | 0.97 | ||
molecular function | 0.9 | ||
transcription factor perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 450.89 (req: < 5)
Gene RIFs: 137 (req: <= 3)
Antibodies: 836 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 450.89 (req: >= 5)
Gene RIFs: 137 (req: > 3)
Antibodies: 836 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0