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Tbio
PDIA3
Protein disulfide-isomerase A3

Protein Summary
Description
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300289
  • ENSP00000300289
  • ENSG00000167004

Symbol
  • ERP57
  • ERP60
  • GRP58
  • P58
  • ER60
  • ERp57
  • ERp60
  • ERp61
  • GRP57
  • GRP58
  • PI-PLC
  • HsT17083
  • HEL-S-269
  • HEL-S-93n
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.97
interacting protein
0.97
molecular function
0.9
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.15   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 836   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.15   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 836   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
2
3
95.2
sex hormone-binding globulin measurement
6
1
6
87.8
platelet crit
1
1
1
85.9
platelet count
1
1
1
85.4
alkaline phosphatase measurement
1
1
1
81.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
95.2
sex hormone-binding globulin measurement
6
87.8
platelet crit
1
85.9
platelet count
1
85.4
alkaline phosphatase measurement
1
81.1
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein disulfide isomerase family A member 3
VGNC:3531
742723
Macaque
protein disulfide isomerase family A member 3
711029
Mouse
MGI:95834
14827
Rat
RGD:68430
29468
Dog
protein disulfide isomerase family A member 3
478279
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein disulfide isomerase family A member 3
Macaque
protein disulfide isomerase family A member 3
Mouse
Rat
Dog
protein disulfide isomerase family A member 3
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30101-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (114)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
Gene Ontology Terms (26)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (287)
1 – 10 of 287
JMJD8
Tbio
Novelty:  0.31175159
p_int:  0.999969903
p_ni:  0.000029233
p_wrong:  8.64e-7
Score:  0.375
Data Source:  BioPlex,STRINGDB
INHA
Tbio
Novelty:  0.00168407
p_int:  0.997895438
p_ni:  0.002104562
Score:  0.54
Data Source:  BioPlex,STRINGDB
CALR
Tbio
Novelty:  0.0004479
Score:  0.999
Data Source:  Reactome,STRINGDB
CANX
Tbio
Novelty:  0.00087002
Score:  0.998
Data Source:  Reactome,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
Score:  0.997
Data Source:  STRINGDB
TAPBP
Tbio
Novelty:  0.00328098
Score:  0.997
Data Source:  STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
Score:  0.992
Data Source:  STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
Score:  0.992
Data Source:  STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
Score:  0.992
Data Source:  STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
Score:  0.992
Data Source:  STRINGDB
Publication Statistics
PubMed Score  399.15

PubMed score by year
PubTator Score  222.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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