Protein Summary
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]
- ENST00000371873
- ENSP00000360939
- ENSG00000162368
- ENST00000450808
- ENSP00000398192
- CMK
- CMPK
- UCK
- UMK
- UMPK
- CK
- CMK
- UMK
- CMPK
- UMPK
- UMP-CMPK
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.96 | ||
kinase perturbation | 0.93 | ||
histone modification site profile | 0.88 | ||
microRNA | 0.87 | ||
biological process | 0.79 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 98.49 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 415 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 98.49 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 415 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (12)
Reactome (3)
KEGG (3)
PathwayCommons (5)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Interconversion of nucleotide di- and triphosphates | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Interconversion of nucleotide di- and triphosphates | ||||
Metabolism | ||||
Metabolism of nucleotides | ||||
Gene Ontology Terms (16)
Functions (6)
Components (5)
Processes (5)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-UniRule | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-UniRule | |||
Protein-Protein Interactions (113)
1 – 10 of 113
TTC19
Novelty: 0.09680022
p_int: 0.99596964
p_ni: 0.00403036
Score: 0.554
Data Source: BioPlex,STRINGDB
UMPS
Family: Enzyme
Novelty: 0.00839563
Score: 0.972
Data Source: STRINGDB
DCK
Family: Kinase
Novelty: 0.00236412
Score: 0.969
Data Source: STRINGDB
NME4
Family: Kinase
Novelty: 0.01754371
Score: 0.967
Data Source: STRINGDB
NME1
Family: Kinase
Novelty: 0.00095088
Score: 0.947
Data Source: STRINGDB
RRM1
Family: Enzyme
Novelty: 0.00116467
Score: 0.944
Data Source: STRINGDB
RRM2B
Family: Enzyme
Novelty: 0.01156406
Score: 0.94
Data Source: STRINGDB
NME6
Family: Kinase
Novelty: 0.1631596
Score: 0.933
Data Source: STRINGDB
RRM2
Family: Enzyme
Novelty: 0.00208763
Score: 0.93
Data Source: STRINGDB
NME7
Family: Enzyme
Novelty: 0.11051019
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score 98.49
PubMed score by year
PubTator Score 61.34
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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