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Tbio
CMPK1
UMP-CMP kinase

Protein Summary
Description
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371873
  • ENSP00000360939
  • ENSG00000162368
  • ENST00000450808
  • ENSP00000398192

Symbol
  • CMK
  • CMPK
  • UCK
  • UMK
  • UMPK
  • CK
  • CMK
  • UMK
  • CMPK
  • UMPK
  • UMP-CMPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
kinase perturbation
0.93
histone modification site profile
0.88
microRNA
0.87
biological process
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.46   (req: < 5)
Gene RIFs: 12   (req: <= 3)
View Gene RIFs
Antibodies: 415   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.46   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 415   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (18)
1 – 5 of 18
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytidine/uridine monophosphate kinase 1
VGNC:8153
456837
Macaque
cytidine/uridine monophosphate kinase 1
710196
Macaque
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic-like
700256
Mouse
cytidine monophosphate (UMP-CMP) kinase 1
MGI:1913838
66588
Rat
cytidine/uridine monophosphate kinase 1
RGD:1310116
298410
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytidine/uridine monophosphate kinase 1
Macaque
cytidine/uridine monophosphate kinase 1
Macaque
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic-like
Mouse
cytidine monophosphate (UMP-CMP) kinase 1
Rat
cytidine/uridine monophosphate kinase 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30085-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
30 targets
R-HSA-499943
Reactome
Metabolism
2112 targets
R-HSA-1430728
Reactome
Metabolism of nucleotides
100 targets
R-HSA-15869
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
30 targets
R-HSA-499943
Metabolism
2112 targets
R-HSA-1430728
Metabolism of nucleotides
100 targets
R-HSA-15869
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
nucleoside monophosphate kinase activity
Inferred from Experiment (EXP)
Reactome
nucleoside diphosphate kinase activity
Inferred from Direct Assay (IDA)
UniProtKB
uridine kinase activity
Traceable Author Statement (TAS)
ProtInc
ATP binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
cytidylate kinase activity
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
uridylate kinase activity
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (113)
1 – 10 of 113
TTC19
Tbio
Novelty: 0.08251578
p_int: 0.99596964
p_ni: 0.00403036
Score: 0.554
Data Source: BioPlex,STRINGDB
UMPS
Tclin
Family: Enzyme
Novelty: 0.00848756
Score: 0.972
Data Source: STRINGDB
DCK
Tchem
Family: Kinase
Novelty: 0.00201831
Score: 0.969
Data Source: STRINGDB
NME4
Tbio
Family: Kinase
Novelty: 0.03735196
Score: 0.967
Data Source: STRINGDB
NME1
Tbio
Family: Kinase
Novelty: 0.00103216
Score: 0.947
Data Source: STRINGDB
RRM1
Tclin
Family: Enzyme
Novelty: 0.00083196
Score: 0.944
Data Source: STRINGDB
RRM2B
Tbio
Family: Enzyme
Novelty: 0.00817283
Score: 0.94
Data Source: STRINGDB
NME6
Tbio
Family: Kinase
Novelty: 0.12087274
Score: 0.933
Data Source: STRINGDB
RRM2
Tclin
Family: Enzyme
Novelty: 0.00112948
Score: 0.93
Data Source: STRINGDB
NME7
Tbio
Family: Enzyme
Novelty: 0.08546782
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  66.46

PubMed score by year
PubTator Score  61.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer