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Tbio
CMPK1
UMP-CMP kinase

Protein Summary
Description
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371873
  • ENSP00000360939
  • ENSG00000162368
  • ENST00000450808
  • ENSP00000398192

Symbol
  • CMK
  • CMPK
  • UCK
  • UMK
  • UMPK
  • CK
  • CMK
  • UMK
  • CMPK
  • UMPK
  • UMP-CMPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
kinase perturbation
0.93
histone modification site profile
0.88
microRNA
0.87
biological process
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.49   (req: < 5)
Gene RIFs: 12   (req: <= 3)
View Gene RIFs
Antibodies: 415   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.49   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 415   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
30 targets
R-HSA-499943
Reactome
Metabolism
2112 targets
R-HSA-1430728
Reactome
Metabolism of nucleotides
100 targets
R-HSA-15869
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
30 targets
R-HSA-499943
Metabolism
2112 targets
R-HSA-1430728
Metabolism of nucleotides
100 targets
R-HSA-15869
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
nucleoside monophosphate kinase activity
Inferred from Experiment (EXP)
Reactome
nucleoside diphosphate kinase activity
Inferred from Direct Assay (IDA)
UniProtKB
uridine kinase activity
Traceable Author Statement (TAS)
ProtInc
ATP binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
cytidylate kinase activity
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
uridylate kinase activity
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (113)
1 – 10 of 113
TTC19
Tbio
Novelty: 0.09680022
p_int: 0.99596964
p_ni: 0.00403036
Score: 0.554
Data Source: BioPlex,STRINGDB
UMPS
Tclin
Family: Enzyme
Novelty: 0.00839563
Score: 0.972
Data Source: STRINGDB
DCK
Tchem
Family: Kinase
Novelty: 0.00236412
Score: 0.969
Data Source: STRINGDB
NME4
Tbio
Family: Kinase
Novelty: 0.01754371
Score: 0.967
Data Source: STRINGDB
NME1
Tbio
Family: Kinase
Novelty: 0.00095088
Score: 0.947
Data Source: STRINGDB
RRM1
Tclin
Family: Enzyme
Novelty: 0.00116467
Score: 0.944
Data Source: STRINGDB
RRM2B
Tbio
Family: Enzyme
Novelty: 0.01156406
Score: 0.94
Data Source: STRINGDB
NME6
Tbio
Family: Kinase
Novelty: 0.1631596
Score: 0.933
Data Source: STRINGDB
RRM2
Tclin
Family: Enzyme
Novelty: 0.00208763
Score: 0.93
Data Source: STRINGDB
NME7
Tbio
Family: Enzyme
Novelty: 0.11051019
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  98.49

PubMed score by year
PubTator Score  61.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer