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Tbio
RPL12
60S ribosomal protein L12

Protein Summary
Description
Binds directly to 26S ribosomal RNA. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361436
  • ENSP00000354739
  • ENSG00000197958
  • ENST00000536368
  • ENSP00000441179

Symbol
  • L12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
small molecule perturbation
1
virus perturbation
0.85
transcription factor binding site profile
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.53   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.53   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
53.7
platelet count
1
1
1
47.7
mean corpuscular hemoglobin concentration
1
1
1
42.3
platelet crit
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
53.7
platelet count
1
47.7
mean corpuscular hemoglobin concentration
1
42.3
platelet crit
1
35
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L12
VGNC:13955
473066
Macaque
60S ribosomal protein L12 pseudogene
713714
Mouse
MGI:98002
269261
Rat
RGD:7600399
102555453
Dog
ribosomal protein L12
480716
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L12
Macaque
60S ribosomal protein L12 pseudogene
Mouse
Rat
Dog
ribosomal protein L12
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30050-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (502)
1 – 10 of 502
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.945339641
p_ni:  0.054660359
Score:  0.594
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.923016217
p_ni:  0.076983783
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.871838305
p_ni:  0.128161695
Score:  0.535
Data Source:  BioPlex,STRINGDB
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.866103906
p_ni:  0.133896094
Data Source:  BioPlex
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.857530107
p_ni:  0.142469893
Score:  0.671
Data Source:  BioPlex,STRINGDB
RPS15A
Tbio
Novelty:  0.03502821
Score:  0.999
Data Source:  STRINGDB
RPS2
Tbio
Novelty:  0.00412313
Score:  0.999
Data Source:  STRINGDB
RPLP2
Tbio
Novelty:  0.00323155
Score:  0.999
Data Source:  STRINGDB
RPL36A
Tbio
Novelty:  0.06115838
Score:  0.999
Data Source:  STRINGDB
RPL13
Tbio
Novelty:  0.0159486
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  79.53

PubMed score by year
PubTator Score  52.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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