Tbio PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial

Protein Summary

Description

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:7733872, PubMed:17707404). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477). This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P30048
• B2R7Z0
• D3DRC9
• E9PH29
• P35690
• Q0D2H1
• Q13776
• Q5T5V2
• Q96HK4

Gene Name

• PRDX3

Ensembl ID

• ENST00000298510
• ENSP00000298510
• ENSG00000165672

Symbol

• AOP1
• AOP1
• MER5
• AOP-1
• SP-22
• HBC189
• PRO1748
• prx-III

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
disease perturbation	0.99
kinase perturbation	0.93
molecular function	0.91
biological process	0.88

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Peroxidase / Thioredoxin-dependent Peroxide Reductase, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Peroxidase / Thioredoxin-dependent Peroxide Reductase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 333.38   (req: < 5)

Gene RIFs: 86   (req: <= 3)

Antibodies: 496   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 333.38   (req: >= 5)

Gene RIFs: 86   (req: > 3)

Antibodies: 496   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0