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Tbio
GCHFR
GTP cyclohydrolase 1 feedback regulatory protein

Protein Summary
Description
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260447
  • ENSP00000260447
  • ENSG00000137880
  • ENST00000559445
  • ENSP00000453871

Symbol
  • GFRP
  • P35
  • GFRP
  • HsT16933
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.72
transcription factor binding site profile
0.69
cell type or tissue
0.68
gene perturbation
0.65
transcription factor
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.09   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.09   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
74.4
waist-hip ratio
1
1
1
42.3
sex hormone-binding globulin measurement
1
1
1
31.4
triglyceride measurement
1
1
1
15.8
BMI-adjusted hip circumference
1
1
1
5.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
74.4
waist-hip ratio
1
42.3
sex hormone-binding globulin measurement
1
31.4
triglyceride measurement
1
15.8
BMI-adjusted hip circumference
1
5.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GTP cyclohydrolase I feedback regulator
VGNC:3550
738961
Mouse
MGI:2443977
320415
Rat
RGD:621746
171128
Dog
GTP cyclohydrolase I feedback regulator
VGNC:41146
487498
Horse
GTP cyclohydrolase I feedback regulator
VGNC:51523
100071314
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GTP cyclohydrolase I feedback regulator
Mouse
Rat
Dog
GTP cyclohydrolase I feedback regulator
Horse
GTP cyclohydrolase I feedback regulator
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P30047-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of cofactors
Reactome
Metabolism of vitamins and cofactors
Reactome
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of cofactors
Metabolism of vitamins and cofactors
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Protein-Protein Interactions (36)
1 – 10 of 36
SPINK2
Tdark
Family:  Enzyme
Novelty:  0.06832697
p_int:  0.999999659
p_ni:  3.4e-7
Data Source:  BioPlex
CAMKK2
Tchem
Family:  Kinase
Novelty:  0.00426898
p_int:  0.999997683
p_ni:  0.000002283
p_wrong:  3.4e-8
Score:  0.241
Data Source:  BioPlex,STRINGDB
CBFB
Tchem
Family:  TF
Novelty:  0.04825679
p_int:  0.999718111
p_ni:  0.000277805
p_wrong:  0.000004084
Score:  0.241
Data Source:  BioPlex,STRINGDB
FXYD1
Tbio
Family:  IC
Novelty:  0.00421639
p_int:  0.999206635
p_ni:  0.000793365
Score:  0.157
Data Source:  BioPlex,STRINGDB
PUSL1
Tdark
Family:  Enzyme
Novelty:  2.39739964
p_int:  0.995527648
p_ni:  0.00446523
p_wrong:  0.000007122
Score:  0.189
Data Source:  BioPlex,STRINGDB
NEBL
Tbio
Novelty:  0.02155964
p_int:  0.995172667
p_ni:  0.000050297
p_wrong:  0.004777037
Score:  0.219
Data Source:  BioPlex,STRINGDB
EIF4G1
Tbio
Novelty:  0.00170995
p_int:  0.978821114
p_ni:  0.021178886
Score:  0.188
Data Source:  BioPlex,STRINGDB
SHARPIN
Tbio
Novelty:  0.0197352
p_int:  0.977734463
p_ni:  0.004964341
p_wrong:  0.017301196
Data Source:  BioPlex
OBSL1
Tbio
Novelty:  0.0325947
p_int:  0.957140859
p_ni:  0.042859141
Data Source:  BioPlex
DOCK11
Tdark
Novelty:  0.0295159
p_int:  0.954657932
p_ni:  0.045341644
p_wrong:  4.24e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  119.09

PubMed score by year
PubTator Score  28.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer