Tbio GCHFR GTP cyclohydrolase 1 feedback regulatory protein

Protein Summary

Description

Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P30047
• B2R4L6
• B7ZLM8
• Q2M1Q2
• Q99749
• GFRP

Gene Name

• GCHFR

Ensembl ID

• ENST00000260447
• ENSP00000260447
• ENSG00000137880
• ENST00000559445
• ENSP00000453871

Symbol

• GFRP
• P35
• GFRP
• HsT16933

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.72
transcription factor binding site profile	0.69
cell type or tissue	0.68
gene perturbation	0.65
transcription factor	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.98   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 206   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.98   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0