You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DDT
D-dopachrome decarboxylase

Protein Summary
Description
Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350608
  • ENSP00000215773
  • ENSG00000099977
  • ENST00000398344
  • ENSP00000381386
  • ENST00000430101
  • ENSP00000399768
  • ENST00000615721
  • ENSP00000481175
  • ENSG00000275003
  • ENST00000626871
  • ENSP00000486829
  • ENST00000629401
  • ENSP00000486384

Symbol
  • D-DT
  • DDCT
  • MIF2
  • MIF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.98
tissue sample
0.59
transcription factor perturbation
0.54
cell type or tissue
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.27   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 335   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.27   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
NKX2-1
Tbio
Family:  TF
Novelty:  0.00077491
Score:  0.732
Data Source:  STRINGDB
SMDT1
Tbio
Novelty:  0.02448475
Score:  0.715
Data Source:  STRINGDB
GAPDH
Tchem
Family:  Enzyme
Novelty:  0.00005849
Score:  0.705
Data Source:  STRINGDB
SERINC3
Tbio
Novelty:  0.02507683
Score:  0.7
Data Source:  STRINGDB
HPGDS
Tchem
Family:  Enzyme
Novelty:  0.00019629
Score:  0.682
Data Source:  STRINGDB
DCT
Tbio
Family:  Enzyme
Novelty:  0.00411451
Score:  0.676
Data Source:  STRINGDB
KDR
Tclin
Family:  Kinase
Novelty:  0.00016219
Score:  0.671
Data Source:  STRINGDB
ACHE
Tclin
Family:  Enzyme
Novelty:  0.00026957
Score:  0.668
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.602
Data Source:  STRINGDB
TST
Tchem
Family:  Enzyme
Novelty:  0.00214991
Score:  0.598
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
4
8
7
3.7
98.6
serum gamma-glutamyl transferase measurement
4
8
7
3.7
98.6
alkaline phosphatase measurement
2
2
1
8.3
78.2
alkaline phosphatase measurement
2
2
1
8.3
78.2
urinary S-phenylmercapturic acid measurement
1
1
1
59.7
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
7
3.7
98.6
serum gamma-glutamyl transferase measurement
7
3.7
98.6
alkaline phosphatase measurement
1
8.3
78.2
alkaline phosphatase measurement
1
8.3
78.2
urinary S-phenylmercapturic acid measurement
1
59.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
D-dopachrome tautomerase
VGNC:12841
747265
Macaque
D-dopachrome tautomerase
699933
Cow
D-dopachrome tautomerase
615999
Species
Name
OMA
EggNOG
Inparanoid
Chimp
D-dopachrome tautomerase
Macaque
D-dopachrome tautomerase
Cow
D-dopachrome tautomerase
Publication Statistics
PubMed Score 91.27
PubMed score by year
PubTator Score 218.32
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title