DDT
D-dopachrome decarboxylase
Protein Summary
Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008]
- ENST00000350608
- ENSP00000215773
- ENSG00000099977
- ENST00000398344
- ENSP00000381386
- ENST00000430101
- ENSP00000399768
- ENST00000615721
- ENSP00000481175
- ENSG00000275003
- ENST00000626871
- ENSP00000486829
- ENST00000629401
- ENSP00000486384
- D-DT
- DDCT
- MIF2
- MIF-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
disease perturbation | 0.98 | ||
tissue sample | 0.59 | ||
transcription factor perturbation | 0.54 | ||
cell type or tissue | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 91.27 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 335 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 91.27 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 335 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0