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Tbio
DDT
D-dopachrome decarboxylase

Protein Summary
Description
Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350608
  • ENSP00000215773
  • ENSG00000099977
  • ENST00000398344
  • ENSP00000381386
  • ENST00000430101
  • ENSP00000399768
  • ENST00000615721
  • ENSP00000481175
  • ENSG00000275003
  • ENST00000626871
  • ENSP00000486829
  • ENST00000629401
  • ENSP00000486384

Symbol
  • D-DT
  • DDCT
  • MIF2
  • MIF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.98
tissue sample
0.59
transcription factor perturbation
0.54
cell type or tissue
0.51


Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.25   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 335   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.25   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
D-dopachrome tautomerase
VGNC:12841
747265
Macaque
D-dopachrome tautomerase
699933
Cow
D-dopachrome tautomerase
615999
Species
Name
OMA
EggNOG
Inparanoid
Chimp
D-dopachrome tautomerase
Macaque
D-dopachrome tautomerase
Cow
D-dopachrome tautomerase
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30046-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (60)
1 – 10 of 60
NKX2-1
Tbio
Family: TF
Novelty: 0.00077491
Score: 0.732
Data Source: STRINGDB
SMDT1
Tbio
Novelty: 0.02448475
Score: 0.715
Data Source: STRINGDB
GAPDH
Tchem
Family: Enzyme
Novelty: 0.00005849
Score: 0.705
Data Source: STRINGDB
SERINC3
Tbio
Novelty: 0.02507683
Score: 0.7
Data Source: STRINGDB
HPGDS
Tchem
Family: Enzyme
Novelty: 0.00019629
Score: 0.682
Data Source: STRINGDB
DCT
Tbio
Family: Enzyme
Novelty: 0.00411451
Score: 0.676
Data Source: STRINGDB
KDR
Tclin
Family: Kinase
Novelty: 0.00016219
Score: 0.671
Data Source: STRINGDB
ACHE
Tclin
Family: Enzyme
Novelty: 0.00026957
Score: 0.668
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00001819
Score: 0.602
Data Source: STRINGDB
TST
Tbio
Family: Enzyme
Novelty: 0.00214991
Score: 0.598
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.25

PubMed score by year
PubTator Score  218.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer