Tbio PRDX5 Peroxiredoxin-5, mitochondrial

Protein Summary

Description

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]

Uniprot Accession IDs

• P30044
• A6NC19
• A6NG06
• B7ZLJ4
• B7ZVW3
• Q14CK0
• Q6IAF2
• Q9UBU5
• Q9UJU4
• Q9UKX4

Gene Name

• PRDX5

Ensembl ID

• ENST00000265462
• ENSP00000265462
• ENSG00000126432
• ENST00000347941
• ENSP00000335363
• ENST00000352435
• ENSP00000335334

Symbol

• ACR1
• PLP
• ACR1
• B166
• PRXV
• PMP20
• PRDX6
• prx-V
• SBBI10
• AOEB166
• HEL-S-55

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
disease perturbation	0.93
molecular function	0.91
histone modification site profile	0.9
cellular component	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.35   (req: < 5)

Gene RIFs: 53   (req: <= 3)

Antibodies: 379   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.35   (req: >= 5)

Gene RIFs: 53   (req: > 3)

Antibodies: 379   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0