You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PRDX5
Peroxiredoxin-5, mitochondrial

Protein Summary
Description
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265462
  • ENSP00000265462
  • ENSG00000126432
  • ENST00000347941
  • ENSP00000335363
  • ENST00000352435
  • ENSP00000335334

Symbol
  • ACR1
  • PLP
  • ACR1
  • B166
  • PRXV
  • PMP20
  • PRDX6
  • prx-V
  • SBBI10
  • AOEB166
  • HEL-S-55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
disease perturbation
0.93
molecular function
0.91
histone modification site profile
0.9
cellular component
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.97   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 379   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.97   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 379   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
30.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
30.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxiredoxin 5
VGNC:1031
743467
Mouse
MGI:1859821
54683
Rat
RGD:71007
113898
Horse
peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355]
Cow
peroxiredoxin 5
VGNC:33303
282885
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxiredoxin 5
Mouse
Rat
Horse
peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355]
Cow
peroxiredoxin 5
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30044-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (34)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (103)
1 – 10 of 103
PRDX1
Tbio
Novelty: 0.00207935
Score: 0.978
Data Source: STRINGDB
PRDX2
Tbio
Novelty: 0.00189751
Score: 0.976
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00181888
Score: 0.967
Data Source: STRINGDB
PRDX6
Tbio
Novelty: 0.00180564
Score: 0.934
Data Source: STRINGDB
SOD2
Tbio
Family: Enzyme
Novelty: 0.00084288
Score: 0.922
Data Source: STRINGDB
PARK7
Tbio
Family: Enzyme
Novelty: 0.00104651
Score: 0.921
Data Source: STRINGDB
PRDX3
Tbio
Family: Enzyme
Novelty: 0.00340119
Score: 0.902
Data Source: STRINGDB
PRDX4
Tbio
Novelty: 0.00692103
Score: 0.874
Data Source: STRINGDB
SOD1
Tbio
Family: Enzyme
Novelty: 0.00039653
Score: 0.863
Data Source: STRINGDB
NIT2
Tbio
Family: Enzyme
Novelty: 0.01003111
Score: 0.838
Data Source: STRINGDB
Publication Statistics
PubMed Score  274.97

PubMed score by year
PubTator Score  569.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer