You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BLVRB
Flavin reductase (NADPH)

Protein Summary
Description
Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263368
  • ENSP00000263368
  • ENSG00000090013

Symbol
  • FLR
  • FLR
  • BVRB
  • SDR43U1
  • HEL-S-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor perturbation
0.88
transcription factor binding site profile
0.79
interacting protein
0.78
disease
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.62   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.62   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
1
2
71.6
reticulocyte measurement
3
1
3
69.3
mean reticulocyte volume
1
1
1
50.6
monocyte percentage of leukocytes
1
1
1
32.7
1
1
0
1.8
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
71.6
reticulocyte measurement
3
69.3
mean reticulocyte volume
1
50.6
monocyte percentage of leukocytes
1
32.7
0
1.8
17.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
biliverdin reductase B
VGNC:2095
456039
Macaque
biliverdin reductase B
703020
Mouse
MGI:2385271
233016
Rat
RGD:1306080
292737
Dog
biliverdin reductase B
VGNC:38472
476456
Species
Name
OMA
EggNOG
Inparanoid
Chimp
biliverdin reductase B
Macaque
biliverdin reductase B
Mouse
Rat
Dog
biliverdin reductase B
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30043-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (31)
Heme degradation (R-HSA-189483)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Heme degradation
Reactome
Metabolism
Reactome
Metabolism of porphyrins
Name
Explore in Pharos
Explore in Source
Heme degradation
Metabolism
Metabolism of porphyrins
Protein-Protein Interactions (75)
1 – 10 of 75
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.999559878
p_ni:  0.000438239
p_wrong:  0.000001884
Data Source:  BioPlex
NENF
Tbio
Novelty:  0.02262843
p_int:  0.999459261
p_ni:  0.000540729
p_wrong:  1e-8
Score:  0.545
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.997988781
p_ni:  0.002011001
p_wrong:  2.18e-7
Data Source:  BioPlex
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.992527643
p_ni:  0.007471329
p_wrong:  0.000001028
Data Source:  BioPlex
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.981955062
p_ni:  0.018027553
p_wrong:  0.000017385
Data Source:  BioPlex
FCGR2A
Tbio
Novelty:  0.00078918
p_int:  0.957838896
p_ni:  0.008613189
p_wrong:  0.033547915
Score:  0.189
Data Source:  BioPlex,STRINGDB
PFN2
Tbio
Novelty:  0.00605366
p_int:  0.94932726
p_ni:  0.048557553
p_wrong:  0.002115187
Score:  0.204
Data Source:  BioPlex,STRINGDB
FSD1
Tbio
Novelty:  0.03452477
p_int:  0.895081174
p_ni:  0.092148666
p_wrong:  0.01277016
Data Source:  BioPlex
ARL6IP6
Tdark
Novelty:  0.36643453
p_int:  0.889657131
p_ni:  0.095213472
p_wrong:  0.015129397
Score:  0.2
Data Source:  BioPlex,STRINGDB
HMOX1
Tchem
Family:  Enzyme
Novelty:  0.00013981
Score:  0.97
Data Source:  STRINGDB
Publication Statistics
PubMed Score  127.62

PubMed score by year
PubTator Score  50.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: