Protein Classes
Protein Summary
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a rol ...more
- ENST00000340385
- ENSP00000342026
- ENSG00000117592
- AOP2
- KIAA0106
- PRX
- p29
- AOP2
- 1-Cys
- NSGPx
- aiPLA2
- HEL-S-128m
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
interacting protein | 0.99 | ||
kinase perturbation | 0.96 | ||
protein complex | 0.96 | ||
transcription factor binding site profile | 0.91 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 573.04 (req: < 5)
Gene RIFs: 76 (req: <= 3)
Antibodies: 550 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 573.04 (req: >= 5)
Gene RIFs: 76 (req: > 3)
Antibodies: 550 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | peroxiredoxin 6 | 706486 | ||||||
Mouse | MGI:894320 | 11758 | ||||||
Rat | RGD:71005 | 94167 | ||||||
Dog | peroxiredoxin 6 | VGNC:44953 | 480069 | |||||
Horse | peroxiredoxin 6 | VGNC:21821 | 100052382 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | peroxiredoxin 6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | peroxiredoxin 6 | |||||
Horse | peroxiredoxin 6 | |||||
Protein Structure (3 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (38)
Reactome (6)
KEGG (1)
WikiPathways (31)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Detoxification of Reactive Oxygen Species | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Detoxification of Reactive Oxygen Species | ||||
Immune System | ||||
Innate Immune System | ||||
Gene Ontology Terms (26)
Functions (9)
Components (9)
Processes (8)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Protein-Protein Interactions (243)
1 – 10 of 243
MAPK1
Family: Kinase
Novelty: 0.00061058
Score: 0.975
Data Source: STRINGDB
GSTP1
Family: Enzyme
Novelty: 0.00045452
Score: 0.967
Data Source: Reactome,STRINGDB
TXNDC5
Novelty: 0.02369481
Score: 0.949
Data Source: STRINGDB
ORM2
Novelty: 0.00837073
Score: 0.941
Data Source: STRINGDB
CTSA
Family: Enzyme
Novelty: 0.00170931
Score: 0.939
Data Source: STRINGDB
PRDX5
Novelty: 0.00369421
Score: 0.934
Data Source: STRINGDB
TXN
Novelty: 0.00048949
Score: 0.933
Data Source: STRINGDB
ANXA2
Novelty: 0.00103362
Score: 0.931
Data Source: STRINGDB
ELANE
Family: Enzyme
Novelty: 0.00026112
Score: 0.93
Data Source: STRINGDB
GDI2
Novelty: 0.02861013
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score 573.04
PubMed score by year
PubTator Score 147
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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