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Tbio
PRDX6
Peroxiredoxin-6

Protein Summary
Description
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a rol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340385
  • ENSP00000342026
  • ENSG00000117592

Symbol
  • AOP2
  • KIAA0106
  • PRX
  • p29
  • AOP2
  • 1-Cys
  • NSGPx
  • aiPLA2
  • HEL-S-128m
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
interacting protein
0.99
kinase perturbation
0.96
protein complex
0.96
transcription factor binding site profile
0.91


IDG Partner Tools
GlyGen
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 573.04   (req: < 5)
View Publications
Gene RIFs: 76   (req: <= 3)
View Gene RIFs
Antibodies: 550   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 573.04   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 550   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (38)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
487 targets
R-HSA-8953897
Reactome
Cellular responses to stress
392 targets
R-HSA-2262752
Reactome
Detoxification of Reactive Oxygen Species
37 targets
R-HSA-3299685
Reactome
Immune System
2246 targets
R-HSA-168256
Reactome
Innate Immune System
1188 targets
R-HSA-168249
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
487 targets
R-HSA-8953897
Cellular responses to stress
392 targets
R-HSA-2262752
Detoxification of Reactive Oxygen Species
37 targets
R-HSA-3299685
Immune System
2246 targets
R-HSA-168256
Innate Immune System
1188 targets
R-HSA-168249
Gene Ontology Terms (26)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
ubiquitin protein ligase binding
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
calcium-independent phospholipase A2 activity
Inferred from Mutant Phenotype (IMP)
CAFA
glutathione peroxidase activity
Inferred from Mutant Phenotype (IMP)
CAFA
protein homodimerization activity
Inferred from Mutant Phenotype (IMP)
CAFA
cadherin binding
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
peroxidase activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
peroxiredoxin activity
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (243)
1 – 10 of 243
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.975
Data Source: STRINGDB
GSTP1
Tchem
Family: Enzyme
Novelty: 0.00045452
Score: 0.967
Data Source: Reactome,STRINGDB
TXNDC5
Tbio
Novelty: 0.02369481
Score: 0.949
Data Source: STRINGDB
ORM2
Tbio
Novelty: 0.00837073
Score: 0.941
Data Source: STRINGDB
CTSA
Tchem
Family: Enzyme
Novelty: 0.00170931
Score: 0.939
Data Source: STRINGDB
PRDX5
Tbio
Novelty: 0.00369421
Score: 0.934
Data Source: STRINGDB
TXN
Tchem
Novelty: 0.00048949
Score: 0.933
Data Source: STRINGDB
ANXA2
Tbio
Novelty: 0.00103362
Score: 0.931
Data Source: STRINGDB
ELANE
Tclin
Family: Enzyme
Novelty: 0.00026112
Score: 0.93
Data Source: STRINGDB
GDI2
Tbio
Novelty: 0.02861013
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  573.04

PubMed score by year
PubTator Score  147

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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