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Tbio
PRDX6
Peroxiredoxin-6

Protein Summary
Description
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a rol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340385
  • ENSP00000342026
  • ENSG00000117592

Symbol
  • AOP2
  • KIAA0106
  • PRX
  • p29
  • AOP2
  • 1-Cys
  • NSGPx
  • aiPLA2
  • HEL-S-128m
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
interacting protein
0.99
kinase perturbation
0.96
protein complex
0.96
transcription factor binding site profile
0.91


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 573.04   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 550   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 573.04   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 550   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
peroxiredoxin 6
706486
Mouse
MGI:894320
11758
Rat
RGD:71005
94167
Dog
peroxiredoxin 6
VGNC:44953
480069
Horse
peroxiredoxin 6
VGNC:21821
100052382
Species
Name
OMA
EggNOG
Inparanoid
Macaque
peroxiredoxin 6
Mouse
Rat
Dog
peroxiredoxin 6
Horse
peroxiredoxin 6
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30041-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (38)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Immune System
Innate Immune System
Gene Ontology Terms (26)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (243)
1 – 10 of 243
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.975
Data Source: STRINGDB
GSTP1
Tchem
Family: Enzyme
Novelty: 0.00045452
Score: 0.967
Data Source: Reactome,STRINGDB
TXNDC5
Tbio
Novelty: 0.02369481
Score: 0.949
Data Source: STRINGDB
ORM2
Tbio
Novelty: 0.00837073
Score: 0.941
Data Source: STRINGDB
CTSA
Tchem
Family: Enzyme
Novelty: 0.00170931
Score: 0.939
Data Source: STRINGDB
PRDX5
Tbio
Novelty: 0.00369421
Score: 0.934
Data Source: STRINGDB
TXN
Tchem
Novelty: 0.00048949
Score: 0.933
Data Source: STRINGDB
ANXA2
Tbio
Novelty: 0.00103362
Score: 0.931
Data Source: STRINGDB
ELANE
Tclin
Family: Enzyme
Novelty: 0.00026112
Score: 0.93
Data Source: STRINGDB
GDI2
Tbio
Novelty: 0.02861013
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  573.04

PubMed score by year
PubTator Score  147

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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