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Tbio
PRDX6
Peroxiredoxin-6

Protein Summary
Description
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a rol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340385
  • ENSP00000342026
  • ENSG00000117592

Symbol
  • AOP2
  • KIAA0106
  • PRX
  • p29
  • AOP2
  • 1-Cys
  • NSGPx
  • aiPLA2
  • HEL-S-128m
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
interacting protein
0.99
kinase perturbation
0.96
protein complex
0.96
transcription factor binding site profile
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 586.91   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 550   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 586.91   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 550   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (243)
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.975
Data Source:  STRINGDB
GSTP1
Tchem
Family:  Enzyme
Novelty:  0.00045452
Score:  0.967
Data Source:  Reactome,STRINGDB
TXNDC5
Tbio
Novelty:  0.02369481
Score:  0.949
Data Source:  STRINGDB
ORM2
Tbio
Novelty:  0.00837073
Score:  0.941
Data Source:  STRINGDB
CTSA
Tchem
Family:  Enzyme
Novelty:  0.00170931
Score:  0.939
Data Source:  STRINGDB
PRDX5
Tbio
Novelty:  0.00369421
Score:  0.934
Data Source:  STRINGDB
TXN
Tchem
Novelty:  0.00048949
Score:  0.933
Data Source:  STRINGDB
ANXA2
Tbio
Novelty:  0.00103362
Score:  0.931
Data Source:  STRINGDB
ELANE
Tclin
Family:  Enzyme
Novelty:  0.00026112
Score:  0.93
Data Source:  STRINGDB
GDI2
Tbio
Novelty:  0.02861013
Score:  0.929
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1
2
50.6
body height
1
1
1
15.8
2
1
2
1.1
11.1
serum IgM measurement
1
1
1
4.2
1
1
0
1.3
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
50.6
body height
1
15.8
2
1.1
11.1
serum IgM measurement
1
4.2
0
1.3
1.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
peroxiredoxin 6
706486
Mouse
MGI:894320
11758
Rat
RGD:71005
94167
Dog
peroxiredoxin 6
VGNC:44953
480069
Horse
peroxiredoxin 6
VGNC:21821
100052382
Species
Name
OMA
EggNOG
Inparanoid
Macaque
peroxiredoxin 6
Mouse
Rat
Dog
peroxiredoxin 6
Horse
peroxiredoxin 6
Publication Statistics
PubMed Score 586.91
PubMed score by year
PubTator Score 147.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title