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Tbio
ERP29
Endoplasmic reticulum resident protein 29

Protein Classes
Protein Summary
Description
Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER. This gene encodes a protein which localizes to the lumen of the endoplasmic reticulum (ER). It is a member of the protein disulfide isomerase (PDI) protein family but lacks an active thioredoxin motif, suggesting that this protein does not function as a disulfide isomerase. The canonical protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261735
  • ENSP00000261735
  • ENSG00000089248
  • ENST00000455836
  • ENSP00000412083

Symbol
  • C12orf8
  • ERP28
  • ERp28
  • ERp31
  • PDIA9
  • PDI-DB
  • C12orf8
  • HEL-S-107
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.93
histone modification site profile
0.87
transcription factor binding site profile
0.86
cellular component
0.85


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.46   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.46   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum protein 29
VGNC:5368
738376
Mouse
MGI:1914647
67397
Rat
RGD:619781
117030
Dog
endoplasmic reticulum protein 29
VGNC:40468
477482
Horse
endoplasmic reticulum protein 29
VGNC:17675
100057258
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum protein 29
Mouse
Rat
Dog
endoplasmic reticulum protein 29
Horse
endoplasmic reticulum protein 29
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30040-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Protein-Protein Interactions (52)
1 – 10 of 52
GLB1L
Tdark
Family: Enzyme
Novelty: 0.43027328
p_int: 0.99999974
p_ni: 1.73e-7
p_wrong: 8.8e-8
Score: 0.269
Data Source: BioPlex,STRINGDB
ALDH16A1
Tdark
Family: Enzyme
Novelty: 0.21880567
p_int: 0.999869135
p_ni: 0.000130865
Score: 0.211
Data Source: BioPlex,STRINGDB
ARSB
Tbio
Family: Enzyme
Novelty: 0.01044355
p_int: 0.999677985
p_ni: 0.000321886
p_wrong: 1.3e-7
Score: 0.273
Data Source: BioPlex,STRINGDB
DERA
Tbio
Family: Enzyme
Novelty: 0.0079635
p_int: 0.999558238
p_ni: 0.000441762
Score: 0.345
Data Source: BioPlex,STRINGDB
EXOC5
Tbio
Novelty: 0.02200205
p_int: 0.99691438
p_ni: 0.003085611
p_wrong: 9e-9
Data Source: BioPlex
HLA-DPB1
Tbio
Novelty: 0.00185371
p_int: 0.826955056
p_ni: 0.173044944
Score: 0.188
Data Source: BioPlex,STRINGDB
CYP2S1
Tbio
Novelty: 0.02967417
Score: 0.8
Data Source: STRINGDB
HSPB1
Tchem
Novelty: 0.00081373
Score: 0.774
Data Source: STRINGDB
EDEM3
Tbio
Family: Enzyme
Novelty: 0.09828323
Score: 0.772
Data Source: STRINGDB
HSPA5
Tchem
Novelty: 0.00043424
Score: 0.769
Data Source: STRINGDB
Publication Statistics
PubMed Score  91.46

PubMed score by year
PubTator Score  49.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer