Tbio P2RY8 P2Y purinoceptor 8

Protein Summary

Description

Probable receptor for purines coupled to G-proteins. The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86VZ1
• P2Y8

Gene Name

• P2RY8

Ensembl ID

• ENST00000381297
• ENSP00000370697
• ENSG00000182162

Symbol

• P2Y8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.7
tissue sample	0.7
cell type or tissue	0.58
cell line	0.46
molecular function	0.42

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Purinoceptor / P2y Receptor / P2y Purinoceptor 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.77   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 191   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.77   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (105)

Explore Interacting Targets

1 – 10 of 105

• See Interactions on String-DB

ATP1A2

Tclin

Family:  Transporter

Novelty:  0.00606202

p_int:  0.999999993

p_ni:  6e-9

p_wrong:  1e-9

Score:  0.189

Data Source:  BioPlex,STRINGDB

ATP1A4

Tclin

Family:  Transporter

Novelty:  0.01011201

p_int:  0.999999928

p_ni:  6.8e-8

p_wrong:  4e-9

Score:  0.17

Data Source:  BioPlex,STRINGDB

TUBA3C

Tchem

Novelty:  0.0187396

p_int:  0.999991067

p_ni:  0.000008933

Data Source:  BioPlex

GFAP

Tbio

Novelty:  0.00020932

p_int:  0.999830539

p_ni:  0.000159158

p_wrong:  0.000010303

Data Source:  BioPlex

ATP2B3

Tbio

Family:  Transporter

Novelty:  0.00901493

p_int:  0.998815059

p_ni:  0.001184941

Data Source:  BioPlex

TMEM11

Tbio

Novelty:  0.00067837

p_int:  0.994144067

p_ni:  0.005588705

p_wrong:  0.000267228

Data Source:  BioPlex

ATL2

Tbio

Novelty:  0.03633884

p_int:  0.976501379

p_ni:  0.023498621

Score:  0.188

Data Source:  BioPlex,STRINGDB

GNAZ

Tbio

Novelty:  0.02008523

p_int:  0.953062372

p_ni:  0.046937589

p_wrong:  3.9e-8

Data Source:  BioPlex

LRRC15

Tbio

Novelty:  0.03701624

p_int:  0.91662062

p_ni:  0.08337938

Data Source:  BioPlex

C19orf25

Tdark

Novelty:  8.61479932

p_int:  0.914777739

p_ni:  0.085221235

p_wrong:  0.000001026

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Neuroactive ligand-receptor interaction	338 targets	path:hsa04080

Name	Explore in Pharos	Explore in Source
Neuroactive ligand-receptor interaction	338 targets	path:hsa04080

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (2)

Components (1)

Processes (2)

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1 – 2 of 2

GO Term	Evidence	Assigned by
G protein-coupled receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
G protein-coupled purinergic nucleotide receptor activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	1	1	1		70.2
lymphocyte percentage of leukocytes	EFO_0007993	1	1	1		60.5
lymphocyte count	EFO_0004587	1	2	2		59.6
mean reticulocyte volume	EFO_0010701	1	1	1		48.5
eosinophil count	EFO_0004842	1	1	1		37.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	1		70.2
lymphocyte percentage of leukocytes	EFO_0007993	1		60.5
lymphocyte count	EFO_0004587	2		59.6
mean reticulocyte volume	EFO_0010701	1		48.5
eosinophil count	EFO_0004842	1		37.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
eosinophil count
eosinophil percentage of leukocytes
lymphocyte count
lymphocyte percentage of leukocytes
mean corpuscular volume
mean reticulocyte volume
neutrophil percentage of leukocytes

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	P2Y receptor family member 8	VGNC:14707	751053
Dog	P2Y purinoceptor 8		491711
Cow	P2Y receptor family member 8	VGNC:32531	100299937
Opossum	P2Y receptor family member 8		100010727
Platypus	P2Y receptor family member 8		100074818

Species	Name	OMA	EggNOG	Inparanoid
Chimp	P2Y receptor family member 8
Dog	P2Y purinoceptor 8
Cow	P2Y receptor family member 8
Opossum	P2Y receptor family member 8
Platypus	P2Y receptor family member 8

Publication Statistics

PubMed Score 17.77

PubMed score by year

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PubTator Score 15.44

PubTator score by year

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Patents

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Related Publications

Text Mined References (14)

GeneRif Annotations (7)

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PMID	Year	Title