Protein Summary
Probable receptor for purines coupled to G-proteins. The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.77 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 191 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.77 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 191 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (105)
ATP1A2
Family: Transporter
Novelty: 0.00606202
p_int: 0.999999993
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
ATP1A4
Family: Transporter
Novelty: 0.01011201
p_int: 0.999999928
p_ni: 6.8e-8
p_wrong: 4e-9
Score: 0.17
Data Source: BioPlex,STRINGDB
GFAP
Novelty: 0.00020932
p_int: 0.999830539
p_ni: 0.000159158
p_wrong: 0.000010303
Data Source: BioPlex
ATP2B3
Family: Transporter
Novelty: 0.00901493
p_int: 0.998815059
p_ni: 0.001184941
Data Source: BioPlex
TMEM11
Novelty: 0.00067837
p_int: 0.994144067
p_ni: 0.005588705
p_wrong: 0.000267228
Data Source: BioPlex
ATL2
Novelty: 0.03633884
p_int: 0.976501379
p_ni: 0.023498621
Score: 0.188
Data Source: BioPlex,STRINGDB
GNAZ
Novelty: 0.02008523
p_int: 0.953062372
p_ni: 0.046937589
p_wrong: 3.9e-8
Data Source: BioPlex
C19orf25
Novelty: 8.61479932
p_int: 0.914777739
p_ni: 0.085221235
p_wrong: 0.000001026
Data Source: BioPlex
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Neuroactive ligand-receptor interaction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Neuroactive ligand-receptor interaction | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 1 | 1 | 70.2 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 60.5 | |||||
lymphocyte count | 1 | 2 | 2 | 59.6 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 48.5 | |||||
eosinophil count | 1 | 1 | 1 | 37.6 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 70.2 | |||||
lymphocyte percentage of leukocytes | 1 | 60.5 | |||||
lymphocyte count | 2 | 59.6 | |||||
mean reticulocyte volume | 1 | 48.5 | |||||
eosinophil count | 1 | 37.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | P2Y receptor family member 8 | VGNC:14707 | 751053 | |||||
Dog | P2Y purinoceptor 8 | 491711 | ||||||
Cow | P2Y receptor family member 8 | VGNC:32531 | 100299937 | |||||
Opossum | P2Y receptor family member 8 | 100010727 | ||||||
Platypus | P2Y receptor family member 8 | 100074818 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | P2Y receptor family member 8 | |||||
Dog | P2Y purinoceptor 8 | |||||
Cow | P2Y receptor family member 8 | |||||
Opossum | P2Y receptor family member 8 | |||||
Platypus | P2Y receptor family member 8 | |||||
Publication Statistics
PubMed Score 17.77
PubMed score by year
PubTator Score 15.44
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (14)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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