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Tchem
P2RY1
P2Y purinoceptor 1

Protein Summary
Description
Receptor for extracellular adenine nucleotides such as ADP (PubMed:9442040, PubMed:9038354, PubMed:25822790). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040). The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305097
  • ENSP00000304767
  • ENSG00000169860

Symbol
  • P2Y1
  • SARCC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.98
ligand (chemical)
0.85
transcription factor binding site profile
0.67
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 476.15   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 476.15   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 401
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (237)
MIB2
Tbio
Family:  Enzyme
Novelty:  0.044378
p_int:  0.999999426
p_ni:  5.72e-7
p_wrong:  1e-9
Score:  0.197
Data Source:  BioPlex,STRINGDB
ATP11C
Tbio
Family:  Transporter
Novelty:  0.05441047
p_int:  0.988197241
p_ni:  0.011802759
Score:  0.179
Data Source:  BioPlex,STRINGDB
CMIP
Tbio
Novelty:  0.0076969
p_int:  0.914885122
p_ni:  2.13e-7
p_wrong:  0.085114666
Score:  0.517
Data Source:  BioPlex,STRINGDB
SLC19A2
Tbio
Family:  Transporter
Novelty:  0.00761796
p_int:  0.913468483
p_ni:  0.08646616
p_wrong:  0.000065358
Score:  0.186
Data Source:  BioPlex,STRINGDB
OSBPL8
Tbio
Novelty:  0.06812531
p_int:  0.82775373
p_ni:  0.17224627
Score:  0.158
Data Source:  BioPlex,STRINGDB
GPM6A
Tbio
Novelty:  0.04123799
p_int:  0.770459572
p_ni:  0.017711648
p_wrong:  0.211828779
Score:  0.169
Data Source:  BioPlex,STRINGDB
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.943
Data Source:  STRINGDB
TBXA2R
Tclin
Family:  GPCR
Novelty:  0.00571066
Score:  0.943
Data Source:  STRINGDB
GRM5
Tchem
Family:  GPCR
Novelty:  0.00062552
Score:  0.939
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.932
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

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1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (52)
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Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
purinergic receptor P2Y1
VGNC:12119
470970
Macaque
purinergic receptor P2Y1
708507
Mouse
MGI:105049
18441
Rat
RGD:3242
25265
Dog
purinergic receptor P2Y1
VGNC:44213
449621
Species
Name
OMA
EggNOG
Inparanoid
Chimp
purinergic receptor P2Y1
Macaque
purinergic receptor P2Y1
Mouse
Rat
Dog
purinergic receptor P2Y1
Publication Statistics
PubMed Score 476.15
PubMed score by year
PubTator Score 408.61
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title