Protein Summary
Receptor for ATP that acts as a ligand-gated ion channel. The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011]
- ENST00000225328
- ENSP00000225328
- ENSG00000083454
- ENST00000345901
- ENSP00000342161
- ENST00000547178
- ENSP00000448355
- ENST00000551178
- ENSP00000447545
- P2X5
- P2X5
- LRH-1
- P2X5R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
gene perturbation | 0.77 | ||
histone modification site profile | 0.67 | ||
disease perturbation | 0.62 | ||
small molecule perturbation | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.78 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 183 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.78 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 183 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2