Tchem CNGA1 cGMP-gated cation channel alpha-1

Protein Summary

Description

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• P29973
• A8K7K6
• J3KPZ2
• Q16279
• Q16485
• Q4W5E3

Gene Name

• CNGA1

Ensembl ID

• ENST00000358519
• ENSP00000351320
• ENSG00000198515
• ENST00000402813
• ENSP00000384264
• ENST00000420489
• ENSP00000389881
• ENST00000514170
• ENSP00000426862
• ENST00000544810
• ENSP00000443401

Symbol

• CNCG
• CNCG1
• CNCG
• CNG1
• RP49
• CNCG1
• CNG-1
• RCNC1
• RCNCa
• RCNCalpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.73
gene perturbation	0.72
tissue sample	0.6
biological process	0.49

Protein Classes

DTO Classes

Protein / Ion Channel / Cyclic Nucleotide-gated Cation Channel Family / Cnga1 Subfamily / Cgmp-gated Cation Channel Alpha-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.79   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.79   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1