You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
AQP1
Aquaporin-1

Protein Summary
Description
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311813
  • ENSP00000311165
  • ENSG00000240583
  • ENST00000409611
  • ENSP00000387178
  • ENST00000409899
  • ENSP00000386712
  • ENST00000441328
  • ENSP00000405698

Symbol
  • CHIP28
  • CO
  • CHIP28
  • AQP-CHIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
gene perturbation
0.85
small molecule perturbation
0.78
disease
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1614.71   (req: < 5)
Gene RIFs: 189   (req: <= 3)
Antibodies: 510   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1614.71   (req: >= 5)
Gene RIFs: 189   (req: > 3)
Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
AQP11
Tbio
Novelty:  0.0229197
Score:  0.855
Data Source:  STRINGDB
AQP12A
Tbio
Novelty:  0.04258853
Score:  0.839
Data Source:  STRINGDB
AVP
Tbio
Novelty:  0.00016475
Score:  0.727
Data Source:  STRINGDB
CA2
Tclin
Family:  Enzyme
Novelty:  0.00040118
Score:  0.699
Data Source:  STRINGDB
SLC9A3
Tclin
Family:  Transporter
Novelty:  0.00146466
Score:  0.691
Data Source:  STRINGDB
SLC12A1
Tclin
Family:  Transporter
Novelty:  0.00303604
Score:  0.66
Data Source:  STRINGDB
VWF
Tclin
Novelty:  0.00009007
Score:  0.65
Data Source:  STRINGDB
KCNJ10
Tbio
Family:  IC
Novelty:  0.00273462
Score:  0.633
Data Source:  STRINGDB
LIN7A
Tbio
Novelty:  0.0202389
Score:  0.63
Data Source:  STRINGDB
SLC4A4
Tbio
Family:  Transporter
Novelty:  0.00352439
Score:  0.626
Data Source:  STRINGDB
Pathways (42)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Erythrocytes take up carbon dioxide and release oxygen
Reactome
Erythrocytes take up oxygen and release carbon dioxide
Reactome
O2/CO2 exchange in erythrocytes
Reactome
Passive transport by Aquaporins
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
O2/CO2 exchange in erythrocytes
Passive transport by Aquaporins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (67)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
6
94.8
1
1
1
84.9
2
2
0
1.2
64.4
bone density
1
1
2
59.8
urolithiasis
1
1
0
1.1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
94.8
1
84.9
0
1.2
64.4
bone density
2
59.8
urolithiasis
0
1.1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aquaporin 1
VGNC:4265
463330
Macaque
aquaporin 1 (Colton blood group)
106997467
Mouse
MGI:103201
11826
Rat
RGD:2141
25240
Dog
aquaporin 1 (Colton blood group)
403732
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aquaporin 1
Macaque
aquaporin 1 (Colton blood group)
Mouse
Rat
Dog
aquaporin 1 (Colton blood group)
Publication Statistics
PubMed Score 1614.71
PubMed score by year
PubTator Score 767.10
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title