Tbio AQP1 Aquaporin-1

Protein Classes

PANTHER Classes

Protein / Transporter / Aquaporin-1

DTO Classes

Protein / Ion Channel / Other Ion Channel / Aquaporin / Aquaporin-1

Protein Summary

Description

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• P29972
• B5BU39
• E7EM69
• E9PC21
• F5GY19
• Q8TBI5
• Q8TDC1
• AQP-1

Gene Name

• AQP1

Ensembl ID

• ENST00000311813
• ENSP00000311165
• ENSG00000240583
• ENST00000409611
• ENSP00000387178
• ENST00000409899
• ENSP00000386712
• ENST00000441328
• ENSP00000405698

Symbol

• CHIP28
• CO
• CHIP28
• AQP-CHIP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	1
gene perturbation	0.85
small molecule perturbation	0.78
disease	0.69

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1590.51   (req: < 5)

Gene RIFs: 189   (req: <= 3)

Antibodies: 510   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1590.51   (req: >= 5)

Gene RIFs: 189   (req: > 3)

Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3	2	6		97.1
bone fracture	EFO_0003931	1	1	1		90.7
bone density	EFO_0003923	1	1	2		56

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	6		97.1
bone fracture	EFO_0003931	1		90.7
bone density	EFO_0003923	2		56

Reset Zoom  Beta Count   Odds Ratio

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	aquaporin 1	VGNC:4265	463330
Macaque	aquaporin 1 (Colton blood group)		106997467
Mouse	aquaporin 1	MGI:103201	11826
Rat	aquaporin 1	RGD:2141	25240
Dog	aquaporin 1 (Colton blood group)		403732

Species	Name	OMA	EggNOG	Inparanoid
Chimp	aquaporin 1
Macaque	aquaporin 1 (Colton blood group)
Mouse	aquaporin 1
Rat	aquaporin 1
Dog	aquaporin 1 (Colton blood group)

Protein Structure (4 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29972-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (42)

Reactome (7)

KEGG (3)

WikiPathways (32)

Aquaporin-mediated transport (R-HSA-445717)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Aquaporin-mediated transport	55 targets	R-HSA-445717
Reactome	Erythrocytes take up carbon dioxide and release oxygen	12 targets	R-HSA-1237044
Reactome	Erythrocytes take up oxygen and release carbon dioxide	8 targets	R-HSA-1247673
Reactome	O2/CO2 exchange in erythrocytes	12 targets	R-HSA-1480926
Reactome	Passive transport by Aquaporins	13 targets	R-HSA-432047

Name	Explore in Pharos	Explore in Source
Aquaporin-mediated transport	55 targets	R-HSA-445717
Erythrocytes take up carbon dioxide and release oxygen	12 targets	R-HSA-1237044
Erythrocytes take up oxygen and release carbon dioxide	8 targets	R-HSA-1247673
O2/CO2 exchange in erythrocytes	12 targets	R-HSA-1480926
Passive transport by Aquaporins	13 targets	R-HSA-432047

Gene Ontology Terms (67)

Functions (11)

Components (15)

Processes (41)

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10

1 – 10 of 11

GO Term	Evidence	Assigned by
ammonium transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
carbon dioxide transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
glycerol transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
intracellular cGMP-activated cation channel activity	Inferred from Direct Assay (IDA)	UniProtKB
nitric oxide transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
water channel activity	Inferred from Direct Assay (IDA)	UniProtKB
water transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
potassium channel activity	Inferred from Mutant Phenotype (IMP)	UniProtKB

Protein-Protein Interactions (96)

Explore Interacting Targets

1 – 10 of 96

• See Interactions on String-DB

AQP11

Tbio

Novelty: 0.0229197

Score: 0.855

Data Source: STRINGDB

AQP12A

Tbio

Novelty: 0.04258853

Score: 0.839

Data Source: STRINGDB

AVP

Tbio

Novelty: 0.00016475

Score: 0.727

Data Source: STRINGDB

CA2

Tclin

Family: Enzyme

Novelty: 0.00040118

Score: 0.699

Data Source: STRINGDB

SLC9A3

Tclin

Family: Transporter

Novelty: 0.00146466

Score: 0.691

Data Source: STRINGDB

SLC12A1

Tclin

Family: Transporter

Novelty: 0.00303604

Score: 0.66

Data Source: STRINGDB

VWF

Tbio

Novelty: 0.00009007

Score: 0.65

Data Source: STRINGDB

KCNJ10

Tbio

Family: IC

Novelty: 0.00273462

Score: 0.633

Data Source: STRINGDB

LIN7A

Tbio

Novelty: 0.0202389

Score: 0.63

Data Source: STRINGDB

SLC4A4

Tbio

Family: Transporter

Novelty: 0.00352439

Score: 0.626

Data Source: STRINGDB

Publication Statistics

PubMed Score  1590.51

PubMed score by year

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PubTator Score  767.1

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Alternative splicing
Blood group antigen
Cell membrane
Complete proteome
Direct protein sequencing
Glycoprotein
Membrane
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

bone density
bone fracture
heel bone mineral density

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cardiovascular system phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
renal/urinary system phenotype
reproductive system phenotype
respiratory system phenotype
skeleton phenotype