Protein Summary
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement. [provided by RefSeq, Aug 2016]
- ENST00000311813
- ENSP00000311165
- ENSG00000240583
- ENST00000409611
- ENSP00000387178
- ENST00000409899
- ENSP00000386712
- ENST00000441328
- ENSP00000405698
- CHIP28
- CO
- CHIP28
- AQP-CHIP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
gene perturbation | 0.85 | ||
small molecule perturbation | 0.78 | ||
disease | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1614.71 (req: < 5)
Gene RIFs: 189 (req: <= 3)
Antibodies: 510 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1614.71 (req: >= 5)
Gene RIFs: 189 (req: > 3)
Antibodies: 510 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 52
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (96)
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (42)
Reactome (7)
KEGG (3)
WikiPathways (32)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Aquaporin-mediated transport | ||||
Reactome | Erythrocytes take up carbon dioxide and release oxygen | ||||
Reactome | Erythrocytes take up oxygen and release carbon dioxide | ||||
Reactome | O2/CO2 exchange in erythrocytes | ||||
Reactome | Passive transport by Aquaporins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Aquaporin-mediated transport | ||||
Erythrocytes take up carbon dioxide and release oxygen | ||||
Erythrocytes take up oxygen and release carbon dioxide | ||||
O2/CO2 exchange in erythrocytes | ||||
Passive transport by Aquaporins | ||||
Viral Interactions (0)
Gene Ontology Terms (67)
Functions (11)
Components (15)
Processes (41)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 2 | 6 | 94.8 | |||||
1 | 1 | 1 | 84.9 | ||||||
2 | 2 | 0 | 1.2 | 64.4 | |||||
bone density | 1 | 1 | 2 | 59.8 | |||||
urolithiasis | 1 | 1 | 0 | 1.1 | 38.8 | ||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 6 | 94.8 | |||||
1 | 84.9 | ||||||
0 | 1.2 | 64.4 | |||||
bone density | 2 | 59.8 | |||||
urolithiasis | 0 | 1.1 | 38.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | aquaporin 1 | VGNC:4265 | 463330 | |||||
Macaque | aquaporin 1 (Colton blood group) | 106997467 | ||||||
Mouse | MGI:103201 | 11826 | ||||||
Rat | RGD:2141 | 25240 | ||||||
Dog | aquaporin 1 (Colton blood group) | 403732 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | aquaporin 1 | |||||
Macaque | aquaporin 1 (Colton blood group) | |||||
Mouse | ||||||
Rat | ||||||
Dog | aquaporin 1 (Colton blood group) | |||||
Publication Statistics
PubMed Score 1614.71
PubMed score by year
PubTator Score 767.10
PubTator score by year
Related Publications
Text Mined References (300)
GeneRif Annotations (189)
Items per page:
0 of 0
PMID | Year | Title |
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