Protein Classes
Protein Summary
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement. [provided by RefSeq, Aug 2016]
- ENST00000311813
- ENSP00000311165
- ENSG00000240583
- ENST00000409611
- ENSP00000387178
- ENST00000409899
- ENSP00000386712
- ENST00000441328
- ENSP00000405698
- CHIP28
- CO
- CHIP28
- AQP-CHIP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
gene perturbation | 0.85 | ||
small molecule perturbation | 0.78 | ||
disease | 0.69 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1311.08 (req: < 5)
Gene RIFs: 189 (req: <= 3)
Antibodies: 510 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1311.08 (req: >= 5)
Gene RIFs: 189 (req: > 3)
Antibodies: 510 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 52
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (42)
Reactome (7)
KEGG (3)
WikiPathways (32)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Aquaporin-mediated transport | ||||
Reactome | Erythrocytes take up carbon dioxide and release oxygen | ||||
Reactome | Erythrocytes take up oxygen and release carbon dioxide | ||||
Reactome | O2/CO2 exchange in erythrocytes | ||||
Reactome | Passive transport by Aquaporins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Aquaporin-mediated transport | ||||
Erythrocytes take up carbon dioxide and release oxygen | ||||
Erythrocytes take up oxygen and release carbon dioxide | ||||
O2/CO2 exchange in erythrocytes | ||||
Passive transport by Aquaporins | ||||
Gene Ontology Terms (67)
Functions (11)
Components (15)
Processes (41)
Items per page:
10
1 – 10 of 11
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Protein-Protein Interactions (96)
1 – 10 of 96
AQP11
Novelty: 0.02650569
Score: 0.855
Data Source: STRINGDB
AQP12A
Novelty: 0.0840303
Score: 0.839
Data Source: STRINGDB
AVP
Novelty: 0.0001163
Score: 0.727
Data Source: STRINGDB
CA2
Family: Enzyme
Novelty: 0.0002565
Score: 0.699
Data Source: STRINGDB
SLC9A3
Family: Transporter
Novelty: 0.00164753
Score: 0.691
Data Source: STRINGDB
SLC12A1
Family: Transporter
Novelty: 0.00394411
Score: 0.66
Data Source: STRINGDB
VWF
Novelty: 0.00010911
Score: 0.65
Data Source: STRINGDB
KCNJ10
Family: IC
Novelty: 0.00337611
Score: 0.633
Data Source: STRINGDB
LIN7A
Novelty: 0.01472118
Score: 0.63
Data Source: STRINGDB
SLC4A4
Family: Transporter
Novelty: 0.00221797
Score: 0.626
Data Source: STRINGDB
Publication Statistics
PubMed Score 1311.08
PubMed score by year
PubTator Score 767.1
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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