Tbio AQP1 Aquaporin-1

Protein Classes

PANTHER Classes

Protein / Transporter / Aquaporin-1

Protein Summary

Description

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• P29972
• B5BU39
• E7EM69
• E9PC21
• F5GY19
• Q8TBI5
• Q8TDC1
• AQP-1

Gene Name

• AQP1

Ensembl ID

• ENST00000311813
• ENSP00000311165
• ENSG00000240583
• ENST00000409611
• ENSP00000387178
• ENST00000409899
• ENSP00000386712
• ENST00000441328
• ENSP00000405698

Symbol

• CHIP28
• CO
• CHIP28
• AQP-CHIP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	1
gene perturbation	0.85
small molecule perturbation	0.78
disease	0.69

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1311.08   (req: < 5)

Gene RIFs: 189   (req: <= 3)

Antibodies: 510   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1311.08   (req: >= 5)

Gene RIFs: 189   (req: > 3)

Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (42)

Reactome (7)

KEGG (3)

WikiPathways (32)

Aquaporin-mediated transport (R-HSA-445717)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Aquaporin-mediated transport	55 targets	R-HSA-445717
Reactome	Erythrocytes take up carbon dioxide and release oxygen	12 targets	R-HSA-1237044
Reactome	Erythrocytes take up oxygen and release carbon dioxide	8 targets	R-HSA-1247673
Reactome	O2/CO2 exchange in erythrocytes	12 targets	R-HSA-1480926
Reactome	Passive transport by Aquaporins	13 targets	R-HSA-432047

Name	Explore in Pharos	Explore in Source
Aquaporin-mediated transport	55 targets	R-HSA-445717
Erythrocytes take up carbon dioxide and release oxygen	12 targets	R-HSA-1237044
Erythrocytes take up oxygen and release carbon dioxide	8 targets	R-HSA-1247673
O2/CO2 exchange in erythrocytes	12 targets	R-HSA-1480926
Passive transport by Aquaporins	13 targets	R-HSA-432047

Gene Ontology Terms (67)

Functions (11)

Components (15)

Processes (41)

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Items per page:

10

1 – 10 of 11

GO Term	Evidence	Assigned by
ammonium transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
carbon dioxide transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
glycerol transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
intracellular cGMP-activated cation channel activity	Inferred from Direct Assay (IDA)	UniProtKB
nitric oxide transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
water channel activity	Inferred from Direct Assay (IDA)	UniProtKB
water transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
potassium channel activity	Inferred from Mutant Phenotype (IMP)	UniProtKB

Protein-Protein Interactions (96)

Explore Interacting Targets

1 – 10 of 96

• See Interactions on String-DB

AQP11

Tbio

Novelty: 0.02650569

Score: 0.855

Data Source: STRINGDB

AQP12A

Tbio

Novelty: 0.0840303

Score: 0.839

Data Source: STRINGDB

AVP

Tbio

Novelty: 0.0001163

Score: 0.727

Data Source: STRINGDB

CA2

Tclin

Family: Enzyme

Novelty: 0.0002565

Score: 0.699

Data Source: STRINGDB

SLC9A3

Tclin

Family: Transporter

Novelty: 0.00164753

Score: 0.691

Data Source: STRINGDB

SLC12A1

Tclin

Family: Transporter

Novelty: 0.00394411

Score: 0.66

Data Source: STRINGDB

VWF

Tbio

Novelty: 0.00010911

Score: 0.65

Data Source: STRINGDB

KCNJ10

Tbio

Family: IC

Novelty: 0.00337611

Score: 0.633

Data Source: STRINGDB

LIN7A

Tbio

Novelty: 0.01472118

Score: 0.63

Data Source: STRINGDB

SLC4A4

Tbio

Family: Transporter

Novelty: 0.00221797

Score: 0.626

Data Source: STRINGDB

Publication Statistics

PubMed Score  1311.08

PubMed score by year

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PubTator Score  767.1

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Alternative splicing
Blood group antigen
Cell membrane
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Glycoprotein
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Phosphoprotein
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GWAS Trait Find Similar Targets

bone density
bone fracture
heel bone mineral density
kidney stone
nephrolithiasis
systolic blood pressure
urolithiasis

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cardiovascular system phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
renal/urinary system phenotype
reproductive system phenotype
respiratory system phenotype
skeleton phenotype