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Tbio
AQP1
Aquaporin-1

Protein Summary
Description
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311813
  • ENSP00000311165
  • ENSG00000240583
  • ENST00000409611
  • ENSP00000387178
  • ENST00000409899
  • ENSP00000386712
  • ENST00000441328
  • ENSP00000405698

Symbol
  • CHIP28
  • CO
  • CHIP28
  • AQP-CHIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
gene perturbation
0.85
small molecule perturbation
0.78
disease
0.69


IDG Partner Tools
GlyGen
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1590.51   (req: < 5)
View Publications
Gene RIFs: 189   (req: <= 3)
View Gene RIFs
Antibodies: 510   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1590.51   (req: >= 5)
Gene RIFs: 189   (req: > 3)
Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
EFO_0009270
3
2
6
97.1
bone fracture
EFO_0003931
1
1
1
90.7
bone density
EFO_0003923
1
1
2
56
Items per page:
1 – 3 of 3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
EFO_0009270
6
97.1
bone fracture
EFO_0003931
1
90.7
bone density
EFO_0003923
2
56
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (42)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
55 targets
R-HSA-445717
Reactome
Erythrocytes take up carbon dioxide and release oxygen
12 targets
R-HSA-1237044
Reactome
Erythrocytes take up oxygen and release carbon dioxide
8 targets
R-HSA-1247673
Reactome
O2/CO2 exchange in erythrocytes
12 targets
R-HSA-1480926
Reactome
Passive transport by Aquaporins
13 targets
R-HSA-432047
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
55 targets
R-HSA-445717
Erythrocytes take up carbon dioxide and release oxygen
12 targets
R-HSA-1237044
Erythrocytes take up oxygen and release carbon dioxide
8 targets
R-HSA-1247673
O2/CO2 exchange in erythrocytes
12 targets
R-HSA-1480926
Passive transport by Aquaporins
13 targets
R-HSA-432047
Gene Ontology Terms (67)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
ammonium transmembrane transporter activity
Inferred from Direct Assay (IDA)
UniProtKB
carbon dioxide transmembrane transporter activity
Inferred from Direct Assay (IDA)
UniProtKB
glycerol transmembrane transporter activity
Inferred from Direct Assay (IDA)
UniProtKB
intracellular cGMP-activated cation channel activity
Inferred from Direct Assay (IDA)
UniProtKB
nitric oxide transmembrane transporter activity
Inferred from Direct Assay (IDA)
UniProtKB
transmembrane transporter activity
Inferred from Direct Assay (IDA)
UniProtKB
water channel activity
Inferred from Direct Assay (IDA)
UniProtKB
water transmembrane transporter activity
Inferred from Direct Assay (IDA)
UniProtKB
identical protein binding
Inferred from Physical Interaction (IPI)
IntAct
potassium channel activity
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (96)
1 – 10 of 96
AQP11
Tbio
Novelty: 0.0229197
Score: 0.855
Data Source: STRINGDB
AQP12A
Tbio
Novelty: 0.04258853
Score: 0.839
Data Source: STRINGDB
AVP
Tbio
Novelty: 0.00016475
Score: 0.727
Data Source: STRINGDB
CA2
Tclin
Family: Enzyme
Novelty: 0.00040118
Score: 0.699
Data Source: STRINGDB
SLC9A3
Tclin
Family: Transporter
Novelty: 0.00146466
Score: 0.691
Data Source: STRINGDB
SLC12A1
Tclin
Family: Transporter
Novelty: 0.00303604
Score: 0.66
Data Source: STRINGDB
VWF
Tbio
Novelty: 0.00009007
Score: 0.65
Data Source: STRINGDB
KCNJ10
Tbio
Family: IC
Novelty: 0.00273462
Score: 0.633
Data Source: STRINGDB
LIN7A
Tbio
Novelty: 0.0202389
Score: 0.63
Data Source: STRINGDB
SLC4A4
Tbio
Family: Transporter
Novelty: 0.00352439
Score: 0.626
Data Source: STRINGDB
Publication Statistics
PubMed Score  1590.51

PubMed score by year
PubTator Score  767.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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