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Tbio
MARCKS
Myristoylated alanine-rich C-kinase substrate

Protein Summary
Description
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000612661
  • ENSP00000478061
  • ENSG00000277443

Symbol
  • MACS
  • PRKCSL
  • MACS
  • 80K-L
  • PKCSL
  • PRKCSL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
ligand (protein) perturbation
0.99
PubMedID
0.98
interacting protein
0.97
transcription factor binding site profile
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 647.53   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 818   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 647.53   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 818   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
household income
2
1
2
33
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
household income
2
33
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
myristoylated alanine rich protein kinase C substrate
694077
Mouse
MGI:96907
17118
Rat
RGD:3028
25603
Cow
myristoylated alanine rich protein kinase C substrate
VGNC:31244
613548
Anole lizard
myristoylated alanine rich protein kinase C substrate
100556430
Species
Name
OMA
EggNOG
Inparanoid
Macaque
myristoylated alanine rich protein kinase C substrate
Mouse
Rat
Cow
myristoylated alanine rich protein kinase C substrate
Anole lizard
myristoylated alanine rich protein kinase C substrate
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P29966-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (34)
Acetylcholine regulates insulin secretion (R-HSA-399997)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine regulates insulin secretion
Reactome
Integration of energy metabolism
Reactome
Metabolism
Reactome
Regulation of insulin secretion
Name
Explore in Pharos
Explore in Source
Acetylcholine regulates insulin secretion
Integration of energy metabolism
Metabolism
Regulation of insulin secretion
Protein-Protein Interactions (64)
1 – 10 of 64
PRKCA
Tchem
Family: Kinase
Novelty: 0.00057611
Score: 0.985
Data Source: Reactome,STRINGDB
PRKCB
Tchem
Family: Kinase
Novelty: 0.00189802
Score: 0.973
Data Source: STRINGDB
PRKCE
Tchem
Family: Kinase
Novelty: 0.00890161
Score: 0.923
Data Source: STRINGDB
CAMK2B
Tchem
Family: Kinase
Novelty: 0.00793595
Score: 0.905
Data Source: STRINGDB
PRKCD
Tclin
Family: Kinase
Novelty: 0.0009758
Score: 0.874
Data Source: STRINGDB
CALM2
Tclin
Novelty: 0.01876254
Score: 0.866
Data Source: STRINGDB
MARCKSL1
Tbio
Novelty: 0.01290798
Score: 0.848
Data Source: STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.843
Data Source: STRINGDB
CALM3
Tclin
Novelty: 0.00461552
Score: 0.826
Data Source: STRINGDB
BASP1
Tbio
Novelty: 0.0097396
Score: 0.789
Data Source: STRINGDB
Publication Statistics
PubMed Score  647.53

PubMed score by year
PubTator Score  510.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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