Protein Summary
Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity). Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway. The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobu ...more
- ENST00000370629
- ENSP00000359663
- ENSG00000102245
- CD40L
- TNFSF5
- TRAP
- IGM
- IMD3
- TRAP
- gp39
- CD154
- CD40L
- HIGM1
- T-BAM
- TNFSF5
- hCD40L
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
hub protein | 0.94 | ||
biological process | 0.79 | ||
gene perturbation | 0.7 | ||
chemical | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3487.5 (req: < 5)
Gene RIFs: 417 (req: <= 3)
Antibodies: 1864 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3487.5 (req: >= 5)
Gene RIFs: 417 (req: > 3)
Antibodies: 1864 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (375)
Nearest Tclin Targets
Pathways (43)
Reactome (6)
KEGG (13)
PathwayCommons (12)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Reactome | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (3)
Components (6)
Processes (19)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
CD40 ligand measurement | 1 | 1 | 1 | 91.7 | |||||
blood protein measurement | 1 | 1 | 1 | 65.8 | |||||
lymphocyte count | 2 | 2 | 2 | 40.9 | |||||
platelet crit | 1 | 1 | 1 | 6.8 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
CD40 ligand measurement | 1 | 91.7 | |||||
blood protein measurement | 1 | 65.8 | |||||
lymphocyte count | 2 | 40.9 | |||||
platelet crit | 1 | 6.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CD40 ligand | VGNC:12233 | 473802 | |||||
Macaque | CD40 ligand | 574160 | ||||||
Mouse | MGI:88337 | 21947 | ||||||
Rat | RGD:708418 | 84349 | ||||||
Dog | CD40 ligand | VGNC:38959 | 403468 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CD40 ligand | |||||
Macaque | CD40 ligand | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD40 ligand | |||||
Publication Statistics
PubMed Score 3487.50
PubMed score by year
PubTator Score 1519.51
PubTator score by year
Related Publications
Text Mined References (475)
GeneRif Annotations (417)
Items per page:
0 of 0
PMID | Year | Title |
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