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Tbio
CD40LG
CD40 ligand

Protein Summary
Description
Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity). Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway. The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370629
  • ENSP00000359663
  • ENSG00000102245

Symbol
  • CD40L
  • TNFSF5
  • TRAP
  • IGM
  • IMD3
  • TRAP
  • gp39
  • CD154
  • CD40L
  • HIGM1
  • T-BAM
  • TNFSF5
  • hCD40L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
hub protein
0.94
biological process
0.79
gene perturbation
0.7
chemical
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3245.54   (req: < 5)
Gene RIFs: 417   (req: <= 3)
Antibodies: 1864   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3245.54   (req: >= 5)
Gene RIFs: 417   (req: > 3)
Antibodies: 1864   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CD40 ligand measurement
1
1
1
85.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CD40 ligand measurement
1
85.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD40 ligand
VGNC:12233
473802
Macaque
CD40 ligand
574160
Mouse
MGI:88337
21947
Rat
RGD:708418
84349
Dog
CD40 ligand
VGNC:38959
403468
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD40 ligand
Macaque
CD40 ligand
Mouse
Rat
Dog
CD40 ligand
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29965-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (43)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cytokine Signaling in Immune system
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Gene Ontology Terms (28)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (375)
1 – 10 of 375
CD40
Tchem
Novelty: 0.0002836
Score: 0.999
Data Source: Reactome,STRINGDB
TNF
Tclin
Novelty: 0.00001457
Score: 0.979
Data Source: STRINGDB
TNFSF13B
Tclin
Novelty: 0.00069885
Score: 0.974
Data Source: STRINGDB
TRAF1
Tbio
Novelty: 0.00526776
Score: 0.964
Data Source: STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.962
Data Source: STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.96
Data Source: STRINGDB
TNFRSF13C
Tbio
Novelty: 0.00198038
Score: 0.957
Data Source: STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
Score: 0.956
Data Source: Reactome,STRINGDB
BIRC2
Tchem
Novelty: 0.00199701
Score: 0.955
Data Source: Reactome,STRINGDB
TRAF3
Tbio
Novelty: 0.0022525
Score: 0.955
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  3245.54

PubMed score by year
PubTator Score  1519.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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