Tbio CD40LG CD40 ligand

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Tumor Necrosis Factor Family Member / Cd40 Ligand

DTO Classes

Protein / Signaling / Cytokine / Tumor Necrosis Factor Family Member / Cd40 Ligand

Protein Summary

Description

Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity). Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway. The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P29965
• CD40-L

Gene Name

• CD40LG

Ensembl ID

• ENST00000370629
• ENSP00000359663
• ENSG00000102245

Symbol

• CD40L
• TNFSF5
• TRAP
• IGM
• IMD3
• TRAP
• gp39
• CD154
• CD40L
• HIGM1
• T-BAM
• TNFSF5
• hCD40L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
hub protein	0.94
biological process	0.79
gene perturbation	0.7
chemical	0.69

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3245.54   (req: < 5)

Gene RIFs: 417   (req: <= 3)

Antibodies: 1864   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3245.54   (req: >= 5)

Gene RIFs: 417   (req: > 3)

Antibodies: 1864   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
CD40 ligand measurement	EFO_0004790	1	1	1		85.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
CD40 ligand measurement	EFO_0004790	1		85.8

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Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	CD40 ligand	VGNC:12233	473802
Macaque	CD40 ligand		574160
Mouse	CD40 ligand	MGI:88337	21947
Rat	CD40 ligand	RGD:708418	84349
Dog	CD40 ligand	VGNC:38959	403468

Species	Name	OMA	EggNOG	Inparanoid
Chimp	CD40 ligand
Macaque	CD40 ligand
Mouse	CD40 ligand
Rat	CD40 ligand
Dog	CD40 ligand

Protein Structure (4 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29965-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (43)

Reactome (6)

KEGG (13)

PathwayCommons (12)

WikiPathways (12)

Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	275 targets	R-HSA-198933
Reactome	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	17 targets	R-HSA-5676594

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	275 targets	R-HSA-198933
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	17 targets	R-HSA-5676594

Gene Ontology Terms (28)

Functions (3)

Components (6)

Processes (19)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
CD40 receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
cytokine activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
tumor necrosis factor receptor binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (375)

Explore Interacting Targets

1 – 10 of 375

• See Interactions on String-DB

CD40

Tchem

Novelty: 0.0002836

Score: 0.999

Data Source: Reactome,STRINGDB

TNF

Tclin

Novelty: 0.00001457

Score: 0.979

Data Source: STRINGDB

TNFSF13B

Tclin

Novelty: 0.00069885

Score: 0.974

Data Source: STRINGDB

TRAF1

Tbio

Novelty: 0.00526776

Score: 0.964

Data Source: STRINGDB

STAT5A

Tchem

Family: TF

Novelty: 0.00074026

Score: 0.962

Data Source: STRINGDB

ITGAM

Tbio

Novelty: 0.00017521

Score: 0.96

Data Source: STRINGDB

TNFRSF13C

Tbio

Novelty: 0.00198038

Score: 0.957

Data Source: STRINGDB

TRAF2

Tbio

Novelty: 0.00983658

Score: 0.956

Data Source: Reactome,STRINGDB

BIRC2

Tchem

Novelty: 0.00199701

Score: 0.955

Data Source: Reactome,STRINGDB

TRAF3

Tbio

Novelty: 0.0022525

Score: 0.955

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  3245.54

PubMed score by year

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PubTator Score  1519.51

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Cell membrane
Complete proteome
Cytokine
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Disease mutation
Disulfide bond
Glycoprotein
Membrane
Polymorphism

GWAS Trait Find Similar Targets

CD40 ligand measurement

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
cellular phenotype
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hematopoietic system phenotype
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immune system phenotype
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