Tbio CD40LG CD40 ligand

Protein Summary

Description

Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity). Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway. The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P29965
• CD40-L

Gene Name

• CD40LG

Ensembl ID

• ENST00000370629
• ENSP00000359663
• ENSG00000102245

Symbol

• CD40L
• TNFSF5
• TRAP
• IGM
• IMD3
• TRAP
• gp39
• CD154
• CD40L
• HIGM1
• T-BAM
• TNFSF5
• hCD40L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
hub protein	0.94
biological process	0.79
gene perturbation	0.7
chemical	0.69

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Tumor Necrosis Factor Family Member / Cd40 Ligand

DTO Classes

Protein / Signaling / Cytokine / Tumor Necrosis Factor Family Member / Cd40 Ligand

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3487.5   (req: < 5)

Gene RIFs: 456   (req: <= 3)

Antibodies: 1864   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3487.5   (req: >= 5)

Gene RIFs: 456   (req: > 3)

Antibodies: 1864   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0