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Tbio
CRABP1
Cellular retinoic acid-binding protein 1

Protein Summary
Description
Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299529
  • ENSP00000299529
  • ENSG00000166426

Symbol
  • RBP5
  • RBP5
  • CRABP
  • CRABPI
  • CRABP-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
PubMedID
0.97
small molecule perturbation
0.69
molecular function
0.63
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 356.73   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 356.73   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
P30536
Tchem
Novelty:  0.00082324
p_int:  0.998046709
p_ni:  0.001953291
Score:  0.485
Data Source:  BioPlex,STRINGDB
CETN1
Tbio
Novelty:  0.01208917
p_int:  0.994326685
p_ni:  0.005673315
Score:  0.188
Data Source:  BioPlex,STRINGDB
CYP26A1
Tchem
Family:  Enzyme
Novelty:  0.00281805
Score:  0.967
Data Source:  Reactome,STRINGDB
CYP26B1
Tchem
Novelty:  0.00990332
Score:  0.956
Data Source:  Reactome,STRINGDB
CYP26C1
Tbio
Novelty:  0.04960237
Score:  0.941
Data Source:  Reactome,STRINGDB
STRA6
Tbio
Novelty:  0.01247638
Score:  0.843
Data Source:  STRINGDB
CACNA1G
Tclin
Family:  IC
Novelty:  0.00380386
Score:  0.753
Data Source:  STRINGDB
NEUROG1
Tbio
Family:  TF
Novelty:  0.00494095
Score:  0.731
Data Source:  STRINGDB
RARS
Tchem
Family:  Enzyme
Novelty:  0.00099479
Score:  0.692
Data Source:  STRINGDB
RUNX3
Tbio
Family:  TF
Novelty:  0.00144472
Score:  0.67
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
RA biosynthesis pathway (R-HSA-5365859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RA biosynthesis pathway
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Reactome
Signaling by Retinoic Acid
Name
Explore in Pharos
Explore in Source
RA biosynthesis pathway
Signal Transduction
Signaling by Nuclear Receptors
Signaling by Retinoic Acid
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
7
8
99.4
reticulocyte count
4
5
8
95.7
reticulocyte measurement
2
4
6
92.2
hematocrit
3
4
4
90.5
hemoglobin measurement
2
2
2
89.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
8
99.4
reticulocyte count
8
95.7
reticulocyte measurement
6
92.2
hematocrit
4
90.5
hemoglobin measurement
2
89.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cellular retinoic acid binding protein 1
VGNC:2478
740693
Macaque
cellular retinoic acid binding protein 1
710048
Mouse
MGI:88490
12903
Rat
RGD:2400
25061
Horse
cellular retinoic acid binding protein 1
VGNC:16846
100050413
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cellular retinoic acid binding protein 1
Macaque
cellular retinoic acid binding protein 1
Mouse
Rat
Horse
cellular retinoic acid binding protein 1
Publication Statistics
PubMed Score 356.73
PubMed score by year
PubTator Score 169.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title