Tbio CRABP1 Cellular retinoic acid-binding protein 1

Protein Summary

Description

Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P29762
• Q6IAY7
• Q8WTV5

Gene Name

• CRABP1

Ensembl ID

• ENST00000299529
• ENSP00000299529
• ENSG00000166426

Symbol

• RBP5
• RBP5
• CRABP
• CRABPI
• CRABP-I

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
PubMedID	0.97
small molecule perturbation	0.69
molecular function	0.63
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.76   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 226   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.76   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0