EEF1D
Elongation factor 1-delta
Protein Summary
Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome. Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, A ...more
- ENST00000317198
- ENSP00000317399
- ENSG00000104529
- ENST00000395119
- ENSP00000378551
- ENST00000419152
- ENSP00000388261
- ENST00000423316
- ENSP00000410059
- ENST00000442189
- ENSP00000391944
- ENST00000524624
- ENSP00000435697
- ENST00000526838
- ENSP00000436507
- ENST00000528610
- ENSP00000431763
- ENST00000529272
- ENSP00000434872
- ENST00000614575
- ENSP00000478340
- ENSG00000273594
- ENST00000615067
- ENSP00000479653
- ENST00000615698
- ENSP00000483527
- ENST00000619144
- ENSP00000477608
- ENST00000620155
- ENSP00000480505
- ENST00000631698
- ENSP00000488672
- ENST00000632587
- ENSP00000487680
- ENST00000632675
- ENSP00000488026
- ENST00000632965
- ENSP00000488275
- EF1D
- EF1D
- EF-1D
- FP1047
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 1 | ||
interacting protein | 1 | ||
ligand (protein) perturbation | 1 | ||
protein complex | 1 | ||
disease perturbation | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.85 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 260 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.85 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 260 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0