You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EEF1D
Elongation factor 1-delta

Protein Summary
Description
Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome. Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, A ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317198
  • ENSP00000317399
  • ENSG00000104529
  • ENST00000395119
  • ENSP00000378551
  • ENST00000419152
  • ENSP00000388261
  • ENST00000423316
  • ENSP00000410059
  • ENST00000442189
  • ENSP00000391944
  • ENST00000524624
  • ENSP00000435697
  • ENST00000526838
  • ENSP00000436507
  • ENST00000528610
  • ENSP00000431763
  • ENST00000529272
  • ENSP00000434872
  • ENST00000614575
  • ENSP00000478340
  • ENSG00000273594
  • ENST00000615067
  • ENSP00000479653
  • ENST00000615698
  • ENSP00000483527
  • ENST00000619144
  • ENSP00000477608
  • ENST00000620155
  • ENSP00000480505
  • ENST00000631698
  • ENSP00000488672
  • ENST00000632587
  • ENSP00000487680
  • ENST00000632675
  • ENSP00000488026
  • ENST00000632965
  • ENSP00000488275

Symbol
  • EF1D
  • EF1D
  • EF-1D
  • FP1047
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
1
ligand (protein) perturbation
1
protein complex
1
disease perturbation
0.98


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.27   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.27   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation elongation factor 1 delta
VGNC:6667
464444
Mouse
MGI:1913906
66656
Rat
RGD:621174
300033
Dog
eukaryotic translation elongation factor 1 delta
VGNC:40208
475115
Horse
eukaryotic translation elongation factor 1 delta
VGNC:17430
100065805
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation elongation factor 1 delta
Mouse
Rat
Dog
eukaryotic translation elongation factor 1 delta
Horse
eukaryotic translation elongation factor 1 delta
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29692-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Eukaryotic Translation Elongation (R-HSA-156842)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Eukaryotic Translation Elongation
Reactome
Metabolism of proteins
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Eukaryotic Translation Elongation
Metabolism of proteins
Translation
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (208)
1 – 10 of 208
EEF1A2
Tchem
Novelty: 0.001472
p_int: 0.999999999
p_ni: 1e-9
Score: 0.923
Data Source: BioPlex,STRINGDB
EEF1A1
Tchem
Novelty: 0.00059953
p_int: 0.999999611
p_ni: 3.89e-7
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
CARS
Tbio
Family: Enzyme
Novelty: 0.02078279
p_int: 0.999988594
p_ni: 0.000011406
Score: 0.829
Data Source: BioPlex,STRINGDB
RNGTT
Tbio
Novelty: 0.01433659
p_int: 0.999986784
p_ni: 0.000012992
p_wrong: 2.24e-7
Score: 0.217
Data Source: BioPlex,STRINGDB
ATP23
Tbio
Family: Enzyme
Novelty: 0.09823059
p_int: 0.999965835
p_ni: 0.000034164
Data Source: BioPlex
VARS
Tchem
Family: Enzyme
Novelty: 0.00720227
p_int: 0.999911839
p_ni: 0.000088161
Score: 0.939
Data Source: BioPlex,STRINGDB
EEF1G
Tbio
Novelty: 0.01473013
p_int: 0.999894076
p_ni: 0.000105924
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
KTN1
Tbio
Novelty: 0.01436672
p_int: 0.99776642
p_ni: 0.00223358
Score: 0.939
Data Source: BioPlex,STRINGDB
EEF1B2
Tbio
Novelty: 0.00970356
p_int: 0.997751934
p_ni: 0.002248066
Score: 0.993
Data Source: BioPlex,Reactome,STRINGDB
ABTB1
Tbio
Novelty: 0.08918942
p_int: 0.996621947
p_ni: 0.003378053
Score: 0.831
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  37.27

PubMed score by year
PubTator Score  28.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer