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Tbio
SERPINA4
Kallistatin

Protein Summary
Description
Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298841
  • ENSP00000298841
  • ENSG00000100665
  • ENST00000555095
  • ENSP00000451172
  • ENST00000557004
  • ENSP00000450838

Symbol
  • KST
  • PI4
  • KAL
  • KST
  • PI4
  • KLST
  • PI-4
  • kallistatin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
tissue
0.61
disease perturbation
0.56
cellular component
0.46
cell line
0.44


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.89   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.89   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
2
4
4
85.2
cathepsin L1 measurement
1
1
1
49.1
vaspin measurement
1
1
1
34.8
prostate specific antigen measurement
1
1
1
24.5
blood protein measurement
1
1
1
10.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
4
85.2
cathepsin L1 measurement
1
49.1
vaspin measurement
1
34.8
prostate specific antigen measurement
1
24.5
blood protein measurement
1
10.2
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family A member 4
VGNC:10241
467544
Rat
RGD:708581
246328
Dog
serpin family A member 4
VGNC:46025
490840
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family A member 4
Rat
Dog
serpin family A member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P29622-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (135)
1 – 10 of 135
PDPK1
Tchem
Family:  Kinase
Novelty:  0.00430458
p_int:  0.996941603
p_ni:  0.003058396
p_wrong:  1e-9
Score:  0.31
Data Source:  BioPlex,STRINGDB
FKBP14
Tbio
Family:  Enzyme
Novelty:  0.02742616
p_int:  0.98672888
p_ni:  0.013258699
p_wrong:  0.000012421
Score:  0.28
Data Source:  BioPlex,STRINGDB
ITIH3
Tbio
Novelty:  0.04201144
Score:  0.952
Data Source:  STRINGDB
APOH
Tbio
Novelty:  0.00049117
Score:  0.936
Data Source:  STRINGDB
ITIH4
Tbio
Novelty:  0.00032471
Score:  0.935
Data Source:  STRINGDB
CTSW
Tbio
Family:  Enzyme
Novelty:  0.05228837
Score:  0.912
Data Source:  STRINGDB
SPP2
Tbio
Novelty:  0.04515855
Score:  0.91
Data Source:  STRINGDB
LGALS3BP
Tbio
Novelty:  0.0025302
Score:  0.908
Data Source:  STRINGDB
RARRES2
Tbio
Novelty:  0.0029178
Score:  0.905
Data Source:  STRINGDB
SELENOP
Tbio
Novelty:  0.00194637
Score:  0.904
Data Source:  STRINGDB
Publication Statistics
PubMed Score  255.89

PubMed score by year
PubTator Score  120.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer