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Tbio
PML
Protein PML

Protein Summary
Description
Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, reg ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268058
  • ENSP00000268058
  • ENSG00000140464
  • ENST00000268059
  • ENSP00000268059
  • ENST00000354026
  • ENSP00000315434
  • ENST00000359928
  • ENSP00000353004
  • ENST00000395132
  • ENSP00000378564
  • ENST00000395135
  • ENSP00000378567
  • ENST00000435786
  • ENSP00000395576
  • ENST00000436891
  • ENSP00000394642
  • ENST00000564428
  • ENSP00000457023
  • ENST00000565898
  • ENSP00000455838
  • ENST00000567543
  • ENSP00000456277
  • ENST00000569477
  • ENSP00000455612
  • ENST00000569965
  • ENSP00000456486

Symbol
  • MYL
  • PP8675
  • RNF71
  • TRIM19
  • MYL
  • RNF71
  • PP8675
  • TRIM19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
virus perturbation
1
transcription factor perturbation
0.96
drug perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.24   (req: < 5)
Gene RIFs: 330   (req: <= 3)
Antibodies: 545   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.24   (req: >= 5)
Gene RIFs: 330   (req: > 3)
Antibodies: 545   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 72
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
1
2
88.1
2
2
2
86.1
body height
2
1
2
83.7
appendicular lean mass
3
1
3
83.1
1
1
0
1.3
76.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
88.1
2
86.1
body height
2
83.7
appendicular lean mass
3
83.1
0
1.3
76.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
promyelocytic leukemia
453736
Macaque
promyelocytic leukemia
700379
Mouse
MGI:104662
18854
Rat
RGD:1562602
315713
Dog
promyelocytic leukemia
487641
Species
Name
OMA
EggNOG
Inparanoid
Chimp
promyelocytic leukemia
Macaque
promyelocytic leukemia
Mouse
Rat
Dog
promyelocytic leukemia
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29590-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (48)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Gene Ontology Terms (84)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (401)
1 – 10 of 401
TUBA3C
Tchem
Novelty: 0.0187396
p_int: 0.999994601
p_ni: 0.000005399
Data Source: BioPlex
GOPC
Tbio
Novelty: 0.01110168
p_int: 0.999988706
p_ni: 0.000011294
Data Source: BioPlex
ACOT8
Tbio
Family: Enzyme
Novelty: 0.02218214
p_int: 0.999972054
p_ni: 0.000027946
Score: 0.519
Data Source: BioPlex,STRINGDB
TNNC2
Tbio
Novelty: 0.07759506
p_int: 0.999894145
p_ni: 0.000105855
Data Source: BioPlex
TULP3
Tbio
Family: TF
Novelty: 0.06911636
p_int: 0.998683501
p_ni: 0.001316499
Data Source: BioPlex
SNX11
Tdark
Novelty: 0.21586113
p_int: 0.998194592
p_ni: 0.001805408
Score: 0.193
Data Source: BioPlex,STRINGDB
TMED7
Tdark
Novelty: 0.31193294
p_int: 0.99608934
p_ni: 0.00391066
Data Source: BioPlex
KLHL40
Tbio
Novelty: 0.0432945
p_int: 0.995079652
p_ni: 0.004920348
Data Source: BioPlex
NDUFS1
Tclin
Family: Enzyme
Novelty: 0.0215624
p_int: 0.989181776
p_ni: 0.010818224
Score: 0.176
Data Source: BioPlex,STRINGDB
TRIML2
Tdark
Family: Enzyme
Novelty: 0.38455379
p_int: 0.982996873
p_ni: 0.017003127
Score: 0.365
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  276.24

PubMed score by year
PubTator Score  1594.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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