Tbio LMOD1 Leiomodin-1

Protein Summary

Description

Mediates nucleation of actin filaments. The leiomodin 1 protein has a putative membrane-spanning region and 2 types of tandemly repeated blocks. The transcript is expressed in all tissues tested, with the highest levels in thyroid, eye muscle, skeletal muscle, and ovary. Increased expression of leiomodin 1 may be linked to Graves' disease and thyroid-associated ophthalmopathy. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P29536
• B1APV6
• C4AMB1
• Q68EN2

Gene Name

• LMOD1

Ensembl ID

• ENST00000367288
• ENSP00000356257
• ENSG00000163431

Symbol

• 1D
• D1
• 64kD
• SMLMOD
• SM-LMOD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.92
cell type or tissue	0.6
microRNA	0.52
biological process	0.49
tissue sample	0.49

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Leiomodin-1

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Leiomodin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.69   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.69   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0