Tbio SERPINB3 Serpin B3

Protein Summary

Description

May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).

Uniprot Accession IDs

• P29508
• A6NDM2
• B2RBT5
• B3W5Y6
• Q53H28
• Q53YB5
• Q86VF3
• Q86W04
• Q8IWL4
• Q8IXI3
• Q96J21
• Q9BYF8

Gene Name

• SERPINB3

Ensembl ID

• ENST00000283752
• ENSP00000283752
• ENSG00000057149
• ENST00000332821
• ENSP00000329498

Symbol

• SCCA
• SCCA1
• SCC
• T4-A
• SCCA1
• SSCA1
• SCCA-1
• HsT1196
• SCCA-PD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.87
interacting protein	0.74
cell type or tissue	0.7
biological term	0.69
gene perturbation	0.67

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Serpin B3

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Serpin B3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 510.48   (req: < 5)

Gene RIFs: 95   (req: <= 3)

Antibodies: 590   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 510.48   (req: >= 5)

Gene RIFs: 95   (req: > 3)

Antibodies: 590   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0