You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SERPINB3
Serpin B3

Protein Summary
Description
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283752
  • ENSP00000283752
  • ENSG00000057149
  • ENST00000332821
  • ENSP00000329498

Symbol
  • SCCA
  • SCCA1
  • SCC
  • T4-A
  • SCCA1
  • SSCA1
  • SCCA-1
  • HsT1196
  • SCCA-PD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.87
interacting protein
0.74
cell type or tissue
0.7
biological term
0.69
gene perturbation
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.08   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 590   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.08   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 590   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
81.5
vitamin D measurement
3
1
3
46.9
eosinophil percentage of leukocytes
1
1
1
9.6
eosinophil percentage of granulocytes
1
1
1
8.2
sum of eosinophil and basophil counts
1
1
1
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
81.5
vitamin D measurement
3
46.9
eosinophil percentage of leukocytes
1
9.6
eosinophil percentage of granulocytes
1
8.2
sum of eosinophil and basophil counts
1
7.9
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family B member 3
VGNC:13283
455459
Mouse
MGI:2683295
394252
Mouse
MGI:1277952
381286
Rat
RGD:1549766
304688
Rat
RGD:1562868
498209
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29508-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (24)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (186)
1 – 10 of 186
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  1
Score:  0.992
Data Source:  BioPlex,STRINGDB
SH3GLB1
Tbio
Novelty:  0.0314974
p_int:  0.99951078
p_ni:  0.000089093
p_wrong:  0.000400127
Score:  0.525
Data Source:  BioPlex,STRINGDB
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.997991851
p_ni:  0.002008149
Data Source:  BioPlex
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.996229829
p_ni:  0.003770171
Data Source:  BioPlex
FTH1
Tbio
Novelty:  0.000863
p_int:  0.981970465
p_ni:  0.018029535
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.981611288
p_ni:  0.018388712
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.980743208
p_ni:  0.019256792
Data Source:  BioPlex
KIR3DS1
Tdark
p_int:  0.965574248
p_ni:  0.034425752
Data Source:  BioPlex
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
p_int:  0.95345693
p_ni:  0.046543064
p_wrong:  6e-9
Score:  0.18
Data Source:  BioPlex,STRINGDB
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.950818672
p_ni:  0.049181328
Data Source:  BioPlex
Publication Statistics
PubMed Score  334.08

PubMed score by year
PubTator Score  2681.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: