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Tbio
SERPINB3
Serpin B3

Protein Summary
Description
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283752
  • ENSP00000283752
  • ENSG00000057149
  • ENST00000332821
  • ENSP00000329498

Symbol
  • SCCA
  • SCCA1
  • SCC
  • T4-A
  • SCCA1
  • SSCA1
  • SCCA-1
  • HsT1196
  • SCCA-PD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.87
interacting protein
0.74
cell type or tissue
0.7
biological term
0.69
gene perturbation
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 510.48   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 590   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 510.48   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 590   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0