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Tchem
NOS1
Nitric oxide synthase, brain

Protein Summary
Description
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317775
  • ENSP00000320758
  • ENSG00000089250
  • ENST00000338101
  • ENSP00000337459
  • ENST00000618760
  • ENSP00000477999

Symbol
  • NOS
  • bNOS
  • nNOS
  • IHPS1
  • N-NOS
  • NC-NOS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
chemical
0.98
biological term
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3262.87   (req: < 5)
Gene RIFs: 228   (req: <= 3)
Antibodies: 871   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3262.87   (req: >= 5)
Gene RIFs: 228   (req: > 3)
Antibodies: 871   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 455
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (455)
1 – 10 of 455
CHEMBL87187
chemical structure image
CHEMBL491923
chemical structure image
CHEMBL312870
chemical structure image
CHEMBL256147,CHEMBL3217190
chemical structure image
CHEMBL113793
chemical structure image
CHEMBL269058
chemical structure image
CHEMBL447183
chemical structure image
CHEMBL545673,CHEMBL451666
chemical structure image
CHEMBL1256014,CHEMBL7890
chemical structure image
CHEMBL293022
chemical structure image
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
4
2
2
6.1
94.7
depressive symptom measurement
2
2
2
94.2
wellbeing measurement
3
1
3
90.6
2
1
0
1.1
59.1
1
1
1
48.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
2
6.1
94.7
depressive symptom measurement
2
94.2
wellbeing measurement
3
90.6
0
1.1
59.1
1
48.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nitric oxide synthase 1
VGNC:5504
467139
Macaque
nitric oxide synthase 1
693781
Mouse
MGI:97360
18125
Rat
RGD:3184
24598
Dog
nitric oxide synthase 1
VGNC:43894
477498
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nitric oxide synthase 1
Macaque
nitric oxide synthase 1
Mouse
Rat
Dog
nitric oxide synthase 1
Protein Structure (38 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29475-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 38
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (38)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Ion homeostasis
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Hemostasis
Immune System
Innate Immune System
Ion homeostasis
Gene Ontology Terms (72)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CACAO
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (198)
1 – 10 of 198
DLG4
Tchem
Novelty: 0.00057285
Score: 0.984
Data Source: STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.98
Data Source: STRINGDB
ATP2B4
Tbio
Family: Transporter
Novelty: 0.00560356
Score: 0.972
Data Source: Reactome,STRINGDB
ARG2
Tchem
Family: Enzyme
Novelty: 0.0006655
Score: 0.966
Data Source: STRINGDB
ARG1
Tchem
Family: Enzyme
Novelty: 0.00063728
Score: 0.964
Data Source: STRINGDB
NOS1AP
Tbio
Family: Enzyme
Novelty: 0.0076555
Score: 0.963
Data Source: STRINGDB
GRIN2A
Tclin
Family: IC
Novelty: 0.00060035
Score: 0.951
Data Source: STRINGDB
ASS1
Tbio
Family: Enzyme
Novelty: 0.00358761
Score: 0.946
Data Source: STRINGDB
CTBP1
Tbio
Novelty: 0.00243818
Score: 0.946
Data Source: STRINGDB
ASL
Tbio
Family: Enzyme
Novelty: 0.00624709
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  3262.87

PubMed score by year
PubTator Score  1287.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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