You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NOS3
Nitric oxide synthase, endothelial

Protein Summary
Description
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297494
  • ENSP00000297494
  • ENSG00000164867
  • ENST00000467517
  • ENSP00000420551
  • ENST00000484524
  • ENSP00000420215

Symbol
  • eNOS
  • ECNOS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
protein domain
1
drug
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8269.37   (req: < 5)
Gene RIFs: 1446   (req: <= 3)
Antibodies: 1530   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8269.37   (req: >= 5)
Gene RIFs: 1446   (req: > 3)
Antibodies: 1530   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 87
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
1
3
1.1
82.5
diastolic blood pressure
2
2
2
80.8
mean platelet volume
2
1
2
67.8
Eczema
1
1
0
1.1
59.5
1
1
0
1.1
59.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
82.5
diastolic blood pressure
2
80.8
mean platelet volume
2
67.8
Eczema
0
1.1
59.5
0
1.1
59.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nitric oxide synthase 3
VGNC:4445
463893
Macaque
nitric oxide synthase 3
714231
Mouse
MGI:97362
18127
Rat
RGD:3186
24600
Dog
nitric oxide synthase 3
VGNC:43896
403784
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nitric oxide synthase 3
Macaque
nitric oxide synthase 3
Mouse
Rat
Dog
nitric oxide synthase 3
Protein Structure (24 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29474-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 24
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (110)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Extra-nuclear estrogen signaling
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Extra-nuclear estrogen signaling
Hemostasis
Immune System
Innate Immune System
Gene Ontology Terms (67)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
BHF-UCL
Protein-Protein Interactions (411)
1 – 10 of 411
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.999
Data Source: Reactome,STRINGDB
CAV1
Tbio
Novelty: 0.00035244
Score: 0.994
Data Source: Reactome,STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.993
Data Source: STRINGDB
HSP90AA1
Tchem
Novelty: 0.00016774
Score: 0.991
Data Source: Reactome,STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.985
Data Source: Reactome,STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.985
Data Source: STRINGDB
ARG2
Tchem
Family: Enzyme
Novelty: 0.0006655
Score: 0.984
Data Source: STRINGDB
NOSTRIN
Tbio
Novelty: 0.05720571
Score: 0.984
Data Source: Reactome,STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.983
Data Source: STRINGDB
KDR
Tclin
Family: Kinase
Novelty: 0.00016219
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  8269.37

PubMed score by year
PubTator Score  3610.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: