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Tchem
NOS3
Nitric oxide synthase, endothelial

Protein Summary
Description
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297494
  • ENSP00000297494
  • ENSG00000164867
  • ENST00000467517
  • ENSP00000420551
  • ENST00000484524
  • ENSP00000420215

Symbol
  • eNOS
  • ECNOS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
protein domain
1
drug
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8371.58   (req: < 5)
Gene RIFs: 1446   (req: <= 3)
Antibodies: 1530   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8371.58   (req: >= 5)
Gene RIFs: 1446   (req: > 3)
Antibodies: 1530   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 94
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
1 – 1 of 1
aminopicoline
Rendered image for aminopicoline
Active Ligands (94)
1 – 10 of 94
CHEMBL87187
Rendered image for CHEMBL87187
CHEMBL491923
Rendered image for CHEMBL491923
GW274150
Rendered image for GW274150
L-NNA
Rendered image for L-NNA
4-methyl-6-propylpyridin-2-amine
Rendered image for 4-methyl-6-propylpyridin-2-amine
CHEMBL191242
Rendered image for CHEMBL191242
Protein-Protein Interactions (411)
1 – 10 of 411
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.999
Data Source:  Reactome,STRINGDB
CAV1
Tbio
Novelty:  0.00035244
Score:  0.994
Data Source:  Reactome,STRINGDB
VEGFA
Tclin
Novelty:  0.0000378
Score:  0.993
Data Source:  STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.991
Data Source:  Reactome,STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.985
Data Source:  Reactome,STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.985
Data Source:  STRINGDB
ARG2
Tchem
Family:  Enzyme
Novelty:  0.0006655
Score:  0.984
Data Source:  STRINGDB
NOSTRIN
Tbio
Novelty:  0.05720571
Score:  0.984
Data Source:  Reactome,STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.983
Data Source:  STRINGDB
KDR
Tclin
Family:  Kinase
Novelty:  0.00016219
Score:  0.982
Data Source:  STRINGDB
Pathways (110)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Extra-nuclear estrogen signaling
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Extra-nuclear estrogen signaling
Hemostasis
Immune System
Innate Immune System
Gene Ontology Terms (67)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
BHF-UCL
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
3
4
94.2
QT interval
7
9
2
1.6
89.4
electrocardiography
2
2
30
11.9
85.6
Agents acting on the renin-angiotensin system use measurement
1
1
1
81.9
Diuretic use measurement
1
1
1
79
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
94.2
QT interval
2
1.6
89.4
electrocardiography
30
11.9
85.6
Agents acting on the renin-angiotensin system use measurement
1
81.9
Diuretic use measurement
1
79
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nitric oxide synthase 3
VGNC:4445
463893
Macaque
nitric oxide synthase 3
714231
Mouse
MGI:97362
18127
Rat
RGD:3186
24600
Dog
nitric oxide synthase 3
VGNC:43896
403784
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nitric oxide synthase 3
Macaque
nitric oxide synthase 3
Mouse
Rat
Dog
nitric oxide synthase 3
Publication Statistics
PubMed Score 8371.58
PubMed score by year
PubTator Score 3610.64
PubTator score by year