Tchem NOS3 Nitric oxide synthase, endothelial

Protein Summary

Description

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• P29474
• A0S0A7
• A0S0A8
• A8KA63
• B2RCQ1
• E9PFR2
• Q13662
• Q14251
• Q14434
• Q548C1
• Q6GSL5
• Q9UDC6

Gene Name

• NOS3

Ensembl ID

• ENST00000297494
• ENSP00000297494
• ENSG00000164867
• ENST00000467517
• ENSP00000420551
• ENST00000484524
• ENSP00000420215

Symbol

• eNOS
• ECNOS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
chemical	1
protein domain	1
drug	0.99

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8958.05   (req: < 5)

Gene RIFs: 1656   (req: <= 3)

Antibodies: 1530   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8958.05   (req: >= 5)

Gene RIFs: 1656   (req: > 3)

Antibodies: 1530   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 94

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1