Tclin IL12B Interleukin-12 subunit beta

Protein Summary

Description

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P29460
• IL-12B

Gene Name

• IL12B

Ensembl ID

• ENST00000231228
• ENSP00000231228
• ENSG00000113302

Symbol

• NKSF2
• CLMF
• NKSF
• CLMF2
• IMD28
• IMD29
• NKSF2
• IL-12B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
chemical	1
biological term	0.99
protein domain	0.92
molecular function	0.79

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Interleukin-12 Subunit Beta

Protein / Defense/immunity Protein / Interleukin-12 Subunit Beta

DTO Classes

Protein / Signaling / Cytokine / Interleukin-12 Subunit Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.18   (req: < 5)

Gene RIFs: 405   (req: <= 3)

Antibodies: 859   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.18   (req: >= 5)

Gene RIFs: 405   (req: > 3)

Antibodies: 859   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 67

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3