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Tclin
IL12B
Interleukin-12 subunit beta

Protein Summary
Description
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231228
  • ENSP00000231228
  • ENSG00000113302

Symbol
  • NKSF2
  • CLMF
  • NKSF
  • CLMF2
  • IMD28
  • IMD29
  • NKSF2
  • IL-12B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
biological term
0.99
protein domain
0.92
molecular function
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.25   (req: < 5)
Gene RIFs: 346   (req: <= 3)
Antibodies: 859   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.25   (req: >= 5)
Gene RIFs: 346   (req: > 3)
Antibodies: 859   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 67
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (107)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-10 signaling
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-12 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-10 signaling
Interleukin-12 family signaling
Interleukin-12 signaling
Gene Ontology Terms (76)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (92)
1 – 10 of 92
IL12A
Tclin
Novelty: 0.07686676
Score: 0.996
Data Source: Reactome,STRINGDB
IL23A
Tclin
Novelty: 0.00535616
Score: 0.995
Data Source: Reactome,STRINGDB
IL23R
Tbio
Novelty: 0.00752821
Score: 0.991
Data Source: Reactome,STRINGDB
IL12RB1
Tbio
Novelty: 0.00474176
Score: 0.973
Data Source: Reactome,STRINGDB
IL12RB2
Tbio
Novelty: 0.02915666
Score: 0.972
Data Source: Reactome,STRINGDB
IL10
Tbio
Novelty: 0.00007359
Score: 0.966
Data Source: STRINGDB
IL4
Tbio
Novelty: 0.00010156
Score: 0.946
Data Source: STRINGDB
IL13
Tbio
Novelty: 0.00043714
Score: 0.945
Data Source: STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00331363
Score: 0.932
Data Source: Reactome,STRINGDB
RELA
Tchem
Family: TF
Novelty: 0.00091233
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  54.25

PubMed score by year
PubTator Score  279.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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