Tclin IL12A Interleukin-12 subunit alpha

Protein Summary

Description

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P29459
• Q96QZ1
• IL-12A

Gene Name

• IL12A

Ensembl ID

• ENST00000305579
• ENSP00000303231
• ENSG00000168811

Symbol

• NKSF1
• P35
• CLMF
• NFSK
• NKSF1
• IL-12A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
chemical	0.97
biological term	0.95
phenotype	0.83
virus perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.65   (req: < 5)

Gene RIFs: 282   (req: <= 3)

Antibodies: 834   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.65   (req: >= 5)

Gene RIFs: 282   (req: > 3)

Antibodies: 834   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1