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Tchem
TKT
Transketolase

Protein Summary
Description
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423516
  • ENSP00000391481
  • ENSG00000163931
  • ENST00000423525
  • ENSP00000405455
  • ENST00000462138
  • ENSP00000417773

Symbol
  • TK
  • TKT1
  • SDDHD
  • HEL107
  • HEL-S-48
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
transcription factor perturbation
0.96
hub protein
0.92
interacting protein
0.88
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.33   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.33   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
1
2
81.1
electrocardiography
1
1
3
58.1
monocyte count
1
1
1
48.3
mathematical ability
1
1
1
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
81.1
electrocardiography
3
58.1
monocyte count
1
48.3
mathematical ability
1
11.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transketolase
VGNC:12208
460443
Macaque
transketolase
694327
Mouse
MGI:105992
21881
Rat
RGD:621036
64524
Dog
transketolase
VGNC:47391
476588
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transketolase
Macaque
transketolase
Mouse
Rat
Dog
transketolase
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29401-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Insulin effects increased synthesis of Xylulose-5-Phosphate (R-HSA-163754)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insulin effects increased synthesis of Xylulose-5-Phosphate
Reactome
Integration of energy metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Reactome
Pentose phosphate pathway
Name
Explore in Pharos
Explore in Source
Insulin effects increased synthesis of Xylulose-5-Phosphate
Integration of energy metabolism
Metabolism
Metabolism of carbohydrates
Pentose phosphate pathway
Protein-Protein Interactions (264)
1 – 10 of 264
KHNYN
Tdark
Novelty: 0.34058138
p_int: 0.999999845
p_ni: 1.11e-7
p_wrong: 4.4e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
GREB1
Tbio
Novelty: 0.01644388
p_int: 0.999633708
p_ni: 0.000366292
Score: 0.187
Data Source: BioPlex,STRINGDB
SMG8
Tdark
Novelty: 0.18080965
p_int: 0.998817515
p_ni: 0.001182485
Data Source: BioPlex
DMWD
Tbio
Novelty: 0.04096001
p_int: 0.995793834
p_ni: 0.004206166
Data Source: BioPlex
ATG2B
Tbio
Novelty: 0.04963717
p_int: 0.987144627
p_ni: 0.012855373
Data Source: BioPlex
FIGNL1
Tbio
Family: Enzyme
Novelty: 0.10817841
p_int: 0.986477181
p_ni: 0.013522819
Score: 0.167
Data Source: BioPlex,STRINGDB
POLA2
Tbio
Family: Enzyme
Novelty: 0.07371844
p_int: 0.986298406
p_ni: 0.01370159
p_wrong: 4e-9
Data Source: BioPlex
WDR54
Tdark
Novelty: 1.19807122
p_int: 0.983223797
p_ni: 0.016776201
p_wrong: 1e-9
Data Source: BioPlex
C5orf34
Tdark
Novelty: 1.01063928
p_int: 0.967938691
p_ni: 0.032061309
Data Source: BioPlex
WDR19
Tbio
Novelty: 0.037197
p_int: 0.961274774
p_ni: 0.038725226
Data Source: BioPlex
Publication Statistics
PubMed Score  278.33

PubMed score by year
PubTator Score  554.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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