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Tclin
LTK
Leukocyte tyrosine kinase receptor

Protein Summary
Description
Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263800
  • ENSP00000263800
  • ENSG00000062524
  • ENST00000355166
  • ENSP00000347293
  • ENST00000453182
  • ENSP00000392196

Symbol
  • TYK1
  • TYK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
protein domain
0.97
ligand (protein) perturbation
0.83
co-expressed gene
0.79
biological process
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.51   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.51   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
IDG Resources
Chemical Tool
(R)-26-amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile
image for (R)-26-amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile
Details:
  • ChEBI: 143117
  • Provider: UNC-CH
  • Activity: 12 nM
  • Selectivity: 0.047
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
2
1.1
84.2
lymphocyte percentage of leukocytes
1
1
1
33.1
high density lipoprotein cholesterol measurement
1
1
1
16.6
albuminuria
1
1
1
4
Drugs used in diabetes use measurement
1
1
1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
84.2
lymphocyte percentage of leukocytes
1
33.1
high density lipoprotein cholesterol measurement
1
16.6
albuminuria
1
4
Drugs used in diabetes use measurement
1
1
Pathways (5)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: inoh
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )
PathwayCommons: inoh
VEGF signaling pathway ( VEGF signaling pathway )
PathwayCommons: inoh
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )
PathwayCommons: inoh
AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) )
PathwayCommons: inoh
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )
Name
Explore in Pharos
Explore in Source
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )
VEGF signaling pathway ( VEGF signaling pathway )
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )
AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) )
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (22)
1 – 10 of 22
ALKAL1
Tbio
Novelty: 0.12828794
Score: 0.775
Data Source: STRINGDB
PIK3R1
Tchem
Family: Kinase
Novelty: 0.00179772
Score: 0.696
Data Source: STRINGDB
SHC1
Tchem
Novelty: 0.00083615
Score: 0.628
Data Source: STRINGDB
CD5
Tbio
Novelty: 0.00032883
Score: 0.547
Data Source: STRINGDB
CBL
Tbio
Family: Enzyme
Novelty: 0.00114929
Score: 0.537
Data Source: STRINGDB
SHD
Tbio
Novelty: 0.05144274
Score: 0.53
Data Source: STRINGDB
PTPN1
Tchem
Family: Enzyme
Novelty: 0.00065779
Score: 0.518
Data Source: STRINGDB
HERC5
Tbio
Family: Enzyme
Novelty: 0.01726248
Score: 0.513
Data Source: STRINGDB
ALKAL2
Tbio
Novelty: 0.12969286
Score: 0.511
Data Source: STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.496
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.51

PubMed score by year
PubTator Score  33.59

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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