Tbio ARID4A AT-rich interactive domain-containing protein 4A

Protein Summary

Description

DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P29374
• Q15991
• Q15992
• Q15993
• ARID domain-containing protein 4A

Gene Name

• ARID4A

Ensembl ID

• ENST00000348476
• ENSP00000344556
• ENSG00000032219
• ENST00000355431
• ENSP00000347602
• ENST00000395168
• ENSP00000378597
• ENST00000431317
• ENSP00000397368

Symbol

• RBBP1
• RBP1
• RBP1
• RBBP1
• RBP-1
• RBBP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.87
histone modification site profile	0.85
protein domain	0.85
transcription factor binding site profile	0.85
transcription factor	0.77

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / At-rich Interactive Domain-containing Protein 4a

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / At-rich Interactive Domain-containing Protein 4a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.57   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.57   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0