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Tchem
MPG
DNA-3-methyladenine glycosylase

Protein Summary
Description
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219431
  • ENSP00000219431
  • ENSG00000103152
  • ENST00000356432
  • ENSP00000348809
  • ENST00000397817
  • ENSP00000380918

Symbol
  • AAG
  • ANPG
  • MID1
  • AAG
  • MDG
  • ADPG
  • APNG
  • Mid1
  • anpg
  • PIG11
  • PIG16
  • CRA36.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
interacting protein
0.82
transcription factor binding site profile
0.68
molecular function
0.67
kinase perturbation
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.4   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.4   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL275938
chemical structure image
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-methylpurine DNA glycosylase
VGNC:13759
749794
Macaque
N-methylpurine DNA glycosylase
722257
Mouse
MGI:97073
268395
Rat
RGD:3106
24561
Dog
N-methylpurine DNA glycosylase
VGNC:43334
611597
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-methylpurine DNA glycosylase
Macaque
N-methylpurine DNA glycosylase
Mouse
Rat
Dog
N-methylpurine DNA glycosylase
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29372-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cleavage of the damaged purine
Reactome
DNA Repair
Reactome
Depurination
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cleavage of the damaged purine
DNA Repair
Depurination
Gene Ontology Terms (12)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (84)
1 – 10 of 84
KBTBD4
Tdark
Novelty: 0.35515885
p_int: 0.999952345
p_ni: 0.000047654
Score: 0.323
Data Source: BioPlex,STRINGDB
ELP3
Tbio
Family: Epigenetic
Novelty: 0.0166061
p_int: 0.999853921
p_ni: 0.000146079
Score: 0.209
Data Source: BioPlex,STRINGDB
ELP2
Tbio
Novelty: 0.03034629
p_int: 0.991228307
p_ni: 0.008771693
Score: 0.534
Data Source: BioPlex,STRINGDB
ELP1
Tbio
Novelty: 0.0035777
p_int: 0.962282645
p_ni: 0.037717355
Score: 0.685
Data Source: BioPlex,STRINGDB
APEX1
Tchem
Family: Enzyme
Novelty: 0.00037532
Score: 0.959
Data Source: Reactome,STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.933
Data Source: STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.932
Data Source: STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.9
Data Source: STRINGDB
GCA
Tbio
Novelty: 0.01485875
Score: 0.836
Data Source: STRINGDB
OGG1
Tbio
Family: Enzyme
Novelty: 0.00074509
Score: 0.811
Data Source: STRINGDB
Publication Statistics
PubMed Score  265.40

PubMed score by year
PubTator Score  449.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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