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Tchem
MPG
DNA-3-methyladenine glycosylase

Protein Summary
Description
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219431
  • ENSP00000219431
  • ENSG00000103152
  • ENST00000356432
  • ENSP00000348809
  • ENST00000397817
  • ENSP00000380918

Symbol
  • AAG
  • ANPG
  • MID1
  • AAG
  • MDG
  • ADPG
  • APNG
  • Mid1
  • anpg
  • PIG11
  • PIG16
  • CRA36.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
interacting protein
0.82
transcription factor binding site profile
0.68
molecular function
0.67
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.38   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.38   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (84)
KBTBD4
Tdark
Novelty:  0.35515885
p_int:  0.999952345
p_ni:  0.000047654
Score:  0.323
Data Source:  BioPlex,STRINGDB
ELP3
Tbio
Family:  Epigenetic
Novelty:  0.0166061
p_int:  0.999853921
p_ni:  0.000146079
Score:  0.209
Data Source:  BioPlex,STRINGDB
ELP2
Tbio
Novelty:  0.03034629
p_int:  0.991228307
p_ni:  0.008771693
Score:  0.534
Data Source:  BioPlex,STRINGDB
ELP1
Tbio
Novelty:  0.0035777
p_int:  0.962282645
p_ni:  0.037717355
Score:  0.685
Data Source:  BioPlex,STRINGDB
APEX1
Tchem
Family:  Enzyme
Novelty:  0.00037532
Score:  0.959
Data Source:  Reactome,STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.933
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.932
Data Source:  STRINGDB
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
Score:  0.9
Data Source:  STRINGDB
GCA
Tbio
Novelty:  0.01485875
Score:  0.836
Data Source:  STRINGDB
OGG1
Tchem
Family:  Enzyme
Novelty:  0.00074509
Score:  0.811
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cleavage of the damaged purine
Reactome
DNA Repair
Reactome
Depurination
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cleavage of the damaged purine
DNA Repair
Depurination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
7
10
12
99.8
reticulocyte measurement
3
12
16
98.3
mean corpuscular volume
3
6
8
98.2
reticulocyte count
7
11
24
97
erythrocyte count
7
8
11
96.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
12
99.8
reticulocyte measurement
16
98.3
mean corpuscular volume
8
98.2
reticulocyte count
24
97
erythrocyte count
11
96.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-methylpurine DNA glycosylase
VGNC:13759
749794
Macaque
N-methylpurine DNA glycosylase
722257
Mouse
MGI:97073
268395
Rat
RGD:3106
24561
Dog
N-methylpurine DNA glycosylase
VGNC:43334
611597
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-methylpurine DNA glycosylase
Macaque
N-methylpurine DNA glycosylase
Mouse
Rat
Dog
N-methylpurine DNA glycosylase
Publication Statistics
PubMed Score 241.38
PubMed score by year
PubTator Score 449.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title