Tchem TACR3 Neuromedin-K receptor

Protein Summary

Description

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P29371
• Q0P510
• NKR

Gene Name

• TACR3

Ensembl ID

• ENST00000304883
• ENSP00000303325
• ENSG00000169836

Symbol

• NK3R
• TAC3R
• NK3
• NKR
• HH11
• NK3R
• NK-3R
• TAC3R
• TAC3RL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.85
gene perturbation	0.74
cellular component	0.71
ligand (protein)	0.68
virus perturbation	0.68

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.17   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 339   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.17   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 575

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

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1 – 1 of 1

eledoisin

TACR3Tchem GPCR

EC50: 9.66

Active Ligands (575)

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1 – 10 of 575

CHEMBL346178

TACR3Tchem GPCR

Kd: 9.89999962

CHEMBL149326

TACR3Tchem GPCR

Ki: 7.01

CHEMBL10284

TACR3Tchem GPCR

Ki: 8.42

CHEMBL10188

TACR3Tchem GPCR

Ki: 9

CHEMBL106124

TACR3Tchem GPCR

Ki: 8.5

CHEMBL447955

TACR3Tchem GPCR

Ki: 8.62

CHEMBL308148

TACR3Tchem GPCR

IC50: 6.5

CHEMBL129683

TACR3Tchem GPCR

Ki: 7.13

CHEMBL3422009

TACR3Tchem GPCR

Ki: 8.7

CHEMBL3422018

TACR3Tchem GPCR

Ki: 8.5

Pathways (13)

Reactome (8)

KEGG (2)

WikiPathways (3)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (q) signalling events	219 targets	R-HSA-416476
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Peptide ligand-binding receptors	189 targets	R-HSA-375276

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (q) signalling events	219 targets	R-HSA-416476
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792
Peptide ligand-binding receptors	189 targets	R-HSA-375276

Gene Ontology Terms (21)

Functions (1)

Components (7)

Processes (13)

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GO Term	Evidence	Assigned by
tachykinin receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (261)

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1 – 10 of 261

• See Interactions on String-DB

C6orf47

Tdark

Novelty: 0.27025154

p_int: 0.999994504

p_ni: 0.000005493

p_wrong: 2e-9

Data Source: BioPlex

SNX27

Tbio

Novelty: 0.02796021

p_int: 0.999960081

p_ni: 0.000039919

Data Source: BioPlex

FARP2

Tbio

Novelty: 0.19204615

p_int: 0.999923549

p_ni: 0.000076409

p_wrong: 4.2e-8

Data Source: BioPlex

DMXL2

Tbio

Novelty: 0.09035497

p_int: 0.999896055

p_ni: 0.000103945

Data Source: BioPlex

RAP1A

Tchem

Family: Enzyme

Novelty: 0.00466391

p_int: 0.999643537

p_ni: 0.000336441

p_wrong: 0.000020022

Data Source: BioPlex

CERS5

Tbio

Family: TF

Novelty: 0.04558376

p_int: 0.999544167

p_ni: 0.000065122

p_wrong: 0.000390711

Data Source: BioPlex

PPFIBP1

Tbio

Novelty: 0.18266164

p_int: 0.999413557

p_ni: 0.000586443

Data Source: BioPlex

USP20

Tbio

Family: Enzyme

Novelty: 0.0779104

p_int: 0.999330858

p_ni: 0.000127423

p_wrong: 0.000541719

Data Source: BioPlex

REEP6

Tbio

Novelty: 0.17493781

p_int: 0.997865197

p_ni: 0.002133356

p_wrong: 0.000001448

Data Source: BioPlex

C2CD5

Tbio

Novelty: 0.79395085

p_int: 0.997309444

p_ni: 0.002689284

p_wrong: 0.000001272

Data Source: BioPlex

Publication Statistics

PubMed Score  280.17

PubMed score by year

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PubTator Score  132.81

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Cell membrane
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