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Tchem
TACR3
Neuromedin-K receptor

Protein Summary
Description
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304883
  • ENSP00000303325
  • ENSG00000169836

Symbol
  • NK3R
  • TAC3R
  • NK3
  • NKR
  • HH11
  • NK3R
  • NK-3R
  • TAC3R
  • TAC3RL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.85
gene perturbation
0.74
cellular component
0.71
ligand (protein)
0.68
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.97   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 339   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.97   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 613
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (261)
C6orf47
Tdark
Novelty:  0.12805293
p_int:  0.999994504
p_ni:  0.000005493
p_wrong:  2e-9
Data Source:  BioPlex
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999960081
p_ni:  0.000039919
Data Source:  BioPlex
FARP2
Tbio
Novelty:  0.09590913
p_int:  0.999923549
p_ni:  0.000076409
p_wrong:  4.2e-8
Data Source:  BioPlex
DMXL2
Tbio
Novelty:  0.06848356
p_int:  0.999896055
p_ni:  0.000103945
Data Source:  BioPlex
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
p_int:  0.999643537
p_ni:  0.000336441
p_wrong:  0.000020022
Data Source:  BioPlex
CERS5
Tbio
Family:  TF
Novelty:  0.02984012
p_int:  0.999544167
p_ni:  0.000065122
p_wrong:  0.000390711
Data Source:  BioPlex
PPFIBP1
Tbio
Novelty:  0.09685089
p_int:  0.999413557
p_ni:  0.000586443
Data Source:  BioPlex
USP20
Tbio
Family:  Enzyme
Novelty:  0.06647037
p_int:  0.999330858
p_ni:  0.000127423
p_wrong:  0.000541719
Data Source:  BioPlex
REEP6
Tbio
Novelty:  0.10645981
p_int:  0.997865197
p_ni:  0.002133356
p_wrong:  0.000001448
Data Source:  BioPlex
C2CD5
Tbio
Novelty:  0.40144687
p_int:  0.997309444
p_ni:  0.002689284
p_wrong:  0.000001272
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
2
3
90
BMI-adjusted hip circumference
1
3
3
72.1
age at menarche
2
2
2
68.5
heel bone mineral density
2
2
2
54.4
body height
1
1
1
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
90
BMI-adjusted hip circumference
3
72.1
age at menarche
2
68.5
heel bone mineral density
2
54.4
body height
1
52.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tachykinin receptor 3
VGNC:12848
461414
Mouse
MGI:892968
21338
Rat
RGD:3810
24808
Dog
tachykinin receptor 3
VGNC:47068
403814
Horse
tachykinin receptor 3
VGNC:23843
100073088
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tachykinin receptor 3
Mouse
Rat
Dog
tachykinin receptor 3
Horse
tachykinin receptor 3
Publication Statistics
PubMed Score 278.97
PubMed score by year
PubTator Score 132.81
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title