Protein Summary
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]
- ENST00000304883
- ENSP00000303325
- ENSG00000169836
- NK3R
- TAC3R
- NK3
- NKR
- HH11
- NK3R
- NK-3R
- TAC3R
- TAC3RL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (chemical) | 0.85 | ||
gene perturbation | 0.74 | ||
cellular component | 0.71 | ||
ligand (protein) | 0.68 | ||
virus perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 278.97 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 339 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 278.97 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 339 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 613
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (613)
Protein-Protein Interactions (261)
C6orf47
Novelty: 0.12805293
p_int: 0.999994504
p_ni: 0.000005493
p_wrong: 2e-9
Data Source: BioPlex
FARP2
Novelty: 0.09590913
p_int: 0.999923549
p_ni: 0.000076409
p_wrong: 4.2e-8
Data Source: BioPlex
RAP1A
Family: Enzyme
Novelty: 0.00375413
p_int: 0.999643537
p_ni: 0.000336441
p_wrong: 0.000020022
Data Source: BioPlex
CERS5
Family: TF
Novelty: 0.02984012
p_int: 0.999544167
p_ni: 0.000065122
p_wrong: 0.000390711
Data Source: BioPlex
USP20
Family: Enzyme
Novelty: 0.06647037
p_int: 0.999330858
p_ni: 0.000127423
p_wrong: 0.000541719
Data Source: BioPlex
REEP6
Novelty: 0.10645981
p_int: 0.997865197
p_ni: 0.002133356
p_wrong: 0.000001448
Data Source: BioPlex
C2CD5
Novelty: 0.40144687
p_int: 0.997309444
p_ni: 0.002689284
p_wrong: 0.000001272
Data Source: BioPlex
Nearest Tclin Targets
Pathways (13)
Reactome (8)
KEGG (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (1)
Components (7)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 3 | 2 | 3 | 90 | |||||
BMI-adjusted hip circumference | 1 | 3 | 3 | 72.1 | |||||
age at menarche | 2 | 2 | 2 | 68.5 | |||||
heel bone mineral density | 2 | 2 | 2 | 54.4 | |||||
body height | 1 | 1 | 1 | 52.7 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
testosterone measurement | 3 | 90 | |||||
BMI-adjusted hip circumference | 3 | 72.1 | |||||
age at menarche | 2 | 68.5 | |||||
heel bone mineral density | 2 | 54.4 | |||||
body height | 1 | 52.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tachykinin receptor 3 | VGNC:12848 | 461414 | |||||
Mouse | MGI:892968 | 21338 | ||||||
Rat | RGD:3810 | 24808 | ||||||
Dog | tachykinin receptor 3 | VGNC:47068 | 403814 | |||||
Horse | tachykinin receptor 3 | VGNC:23843 | 100073088 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tachykinin receptor 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tachykinin receptor 3 | |||||
Horse | tachykinin receptor 3 | |||||
Publication Statistics
PubMed Score 278.97
PubMed score by year
PubTator Score 132.81
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (54)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
|---|