Tchem SHC1 SHC-transforming protein 1

Protein Summary

Description

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• P29353
• B5BU19
• D3DV78
• O15290
• Q5T180
• Q5T183
• Q5T184
• Q5T185
• Q5T186
• Q8N4K5
• Q96CL1

Gene Name

• SHC1

Ensembl ID

• ENST00000368445
• ENSP00000357430
• ENSG00000160691
• ENST00000368450
• ENSP00000357435
• ENST00000368453
• ENSP00000357438
• ENST00000448116
• ENSP00000401303

Symbol

• SHC
• SHCA
• SHC
• SHCA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
kinase	1
pathway	0.98
biological process	0.96
biological term	0.96

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Shc-transforming Protein 1

DTO Classes

Protein / Signaling / Shc-transforming Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1365.09   (req: < 5)

Gene RIFs: 172   (req: <= 3)

Antibodies: 1084   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1365.09   (req: >= 5)

Gene RIFs: 172   (req: > 3)

Antibodies: 1084   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0