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Tchem
SHC1
SHC-transforming protein 1

Protein Classes
Protein Summary
Description
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368445
  • ENSP00000357430
  • ENSG00000160691
  • ENST00000368450
  • ENSP00000357435
  • ENST00000368453
  • ENSP00000357438
  • ENST00000448116
  • ENSP00000401303

Symbol
  • SHC
  • SHCA
  • SHC
  • SHCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
kinase
1
pathway
0.98
biological process
0.96
biological term
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
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GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1097.4   (req: < 5)
Gene RIFs: 144   (req: <= 3)
Antibodies: 1084   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1097.4   (req: >= 5)
Gene RIFs: 144   (req: > 3)
Antibodies: 1084   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
1
2
83.8
1
1
0
1.4
37.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
83.8
0
1.4
37.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SHC adaptor protein 1
VGNC:10417
457351
Macaque
SHC adaptor protein 1
718982
Mouse
MGI:98296
20416
Rat
RGD:620446
85385
Dog
SHC adaptor protein 1
VGNC:46140
490439
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SHC adaptor protein 1
Macaque
SHC adaptor protein 1
Mouse
Rat
Dog
SHC adaptor protein 1
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (209)
Activated NTRK2 signals through RAS (R-HSA-9026519)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 83
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through RAS
Reactome
Activated NTRK3 signals through RAS
Reactome
Axon guidance
Reactome
Cell surface interactions at the vascular wall
Reactome
Constitutive Signaling by EGFRvIII
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through RAS
Activated NTRK3 signals through RAS
Axon guidance
Cell surface interactions at the vascular wall
Constitutive Signaling by EGFRvIII
Gene Ontology Terms (47)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (405)
1 – 10 of 405
SHC2
Tbio
Novelty: 0.00219395
p_int: 0.999999983
p_wrong: 1.7e-8
Score: 0.938
Data Source: BioPlex,STRINGDB
OXT
Tbio
Novelty: 0.00005116
p_int: 0.999997979
p_ni: 0.000002021
Score: 0.205
Data Source: BioPlex,STRINGDB
RASAL2
Tbio
Family: Enzyme
Novelty: 0.03671142
p_int: 0.999993855
p_ni: 0.000006103
p_wrong: 4.1e-8
Score: 0.311
Data Source: BioPlex,STRINGDB
RFFL
Tbio
Family: Enzyme
Novelty: 0.06621524
p_int: 0.999981591
p_ni: 0.000018407
p_wrong: 2e-9
Score: 0.455
Data Source: BioPlex,STRINGDB
PTPN12
Tchem
Family: Enzyme
Novelty: 0.01333491
p_int: 0.999950295
p_ni: 0.000049705
Score: 0.972
Data Source: BioPlex,Reactome,STRINGDB
ARHGEF7
Tbio
Novelty: 0.00919946
p_int: 0.999547729
p_ni: 0.000449798
p_wrong: 0.000002472
Score: 0.294
Data Source: BioPlex,STRINGDB
CORO2B
Tdark
Novelty: 0.30665394
p_int: 0.999413613
p_ni: 0.000586343
p_wrong: 4.4e-8
Score: 0.236
Data Source: BioPlex,STRINGDB
PEAK1
Tbio
Family: Kinase
Novelty: 0.02919858
p_int: 0.999111626
p_ni: 0.000888374
Score: 0.44
Data Source: BioPlex,STRINGDB
GAREM1
Tbio
Novelty: 0.21021078
p_int: 0.994562612
p_ni: 0.005400901
p_wrong: 0.000036487
Score: 0.357
Data Source: BioPlex,STRINGDB
CDC25C
Tchem
Family: Enzyme
Novelty: 0.00227769
p_int: 0.981733651
p_ni: 0.018266346
p_wrong: 3e-9
Score: 0.346
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1097.40

PubMed score by year
PubTator Score  545.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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