Protein Classes
Protein Summary
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of developm ...more
- ENST00000374630
- ENSP00000363761
- ENSG00000133216
- ENST00000374632
- ENSP00000363763
- ENST00000400191
- ENSP00000383053
- DRT
- EPHT3
- EPTH3
- ERK
- HEK5
- TYRO5
- DRT
- EK5
- ERK
- CAPB
- Hek5
- PCBC
- EPHT3
- Tyro5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
protein domain | 1 | ||
molecular function | 0.99 | ||
transcription factor perturbation | 0.88 | ||
biological process | 0.86 | ||
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 502.85 (req: < 5)
Gene RIFs: 74 (req: <= 3)
Antibodies: 611 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 502.85 (req: >= 5)
Gene RIFs: 74 (req: > 3)
Antibodies: 611 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 52
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 8
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Approved Drugs (3)
1 – 3 of 3
Active Ligands (8)
1 – 8 of 8
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triiodothyronine measurement | 2 | 1 | 2 | 35.2 | |||||
thyroxine measurement | 1 | 1 | 1 | 22.7 | |||||
waist-hip ratio | 1 | 1 | 1 | 19.8 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triiodothyronine measurement | 2 | 35.2 | |||||
thyroxine measurement | 1 | 22.7 | |||||
waist-hip ratio | 1 | 19.8 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | EPH receptor B2 | VGNC:10612 | 456613 | |||||
Mouse | MGI:99611 | 13844 | ||||||
Rat | RGD:1564232 | 313633 | ||||||
Dog | EPH receptor B2 | VGNC:40411 | 487380 | |||||
Cow | EPH receptor B2 | VGNC:54424 | 535137 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | EPH receptor B2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | EPH receptor B2 | |||||
Cow | EPH receptor B2 | |||||
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (208)
Reactome (6)
KEGG (1)
PathwayCommons (7)
WikiPathways (194)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Reactome | Ephrin signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
Ephrin signaling | ||||
Gene Ontology Terms (67)
Functions (10)
Components (15)
Processes (42)
Items per page:
10
1 – 10 of 10
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | ARUK-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | ARUK-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (245)
1 – 10 of 245
SPSB2
Novelty: 0.07223184
p_int: 0.999999981
p_ni: 1.7e-8
p_wrong: 2e-9
Score: 0.557
Data Source: BioPlex,STRINGDB
EFNB2
Novelty: 0.00255095
p_int: 0.999999861
p_ni: 5.9e-8
p_wrong: 8e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
MYCBP2
Family: Enzyme
Novelty: 0.00413684
p_int: 0.999796533
p_ni: 0.000203468
Data Source: BioPlex
FBXO45
Novelty: 0.05784607
p_int: 0.999685567
p_ni: 0.000305167
p_wrong: 0.000009266
Data Source: BioPlex
HSPA5
Novelty: 0.00043424
p_int: 0.90002893
p_ni: 0.09997107
Score: 0.157
Data Source: BioPlex,STRINGDB
EFNA5
Novelty: 0.00134985
Score: 0.999
Data Source: STRINGDB
EFNB1
Novelty: 0.00523161
Score: 0.997
Data Source: STRINGDB
EFNA1
Family: Kinase
Novelty: 0.00732252
Score: 0.993
Data Source: STRINGDB
EFNA3
Novelty: 0.01819539
Score: 0.993
Data Source: STRINGDB
EFNA2
Novelty: 0.01184859
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score 502.85
PubMed score by year
PubTator Score 379.27
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Ortholog Sequence Conservation
PolarG S T Y C
NeutralQ N
BasicK R H
AcidicD E
HydrophobicA V L I P W F M
Find similar targets by:
UniProt Keyword