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Tchem
EPHB2
Ephrin type-B receptor 2

Protein Summary
Description
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of developm ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374630
  • ENSP00000363761
  • ENSG00000133216
  • ENST00000374632
  • ENSP00000363763
  • ENST00000400191
  • ENSP00000383053

Symbol
  • DRT
  • EPHT3
  • EPTH3
  • ERK
  • HEK5
  • TYRO5
  • DRT
  • EK5
  • ERK
  • CAPB
  • Hek5
  • PCBC
  • EPHT3
  • Tyro5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
protein domain
1
molecular function
0.99
transcription factor perturbation
0.88
biological process
0.86


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 502.85   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 611   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 502.85   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 611   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triiodothyronine measurement
2
1
2
35.2
thyroxine measurement
1
1
1
22.7
waist-hip ratio
1
1
1
19.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triiodothyronine measurement
2
35.2
thyroxine measurement
1
22.7
waist-hip ratio
1
19.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EPH receptor B2
VGNC:10612
456613
Mouse
MGI:99611
13844
Rat
RGD:1564232
313633
Dog
EPH receptor B2
VGNC:40411
487380
Cow
EPH receptor B2
VGNC:54424
535137
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EPH receptor B2
Mouse
Rat
Dog
EPH receptor B2
Cow
EPH receptor B2
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (208)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Reactome
Ephrin signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Ephrin signaling
Gene Ontology Terms (67)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (245)
1 – 10 of 245
SPSB2
Tbio
Novelty: 0.07223184
p_int: 0.999999981
p_ni: 1.7e-8
p_wrong: 2e-9
Score: 0.557
Data Source: BioPlex,STRINGDB
EFNB2
Tbio
Novelty: 0.00255095
p_int: 0.999999861
p_ni: 5.9e-8
p_wrong: 8e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
MYCBP2
Tbio
Family: Enzyme
Novelty: 0.00413684
p_int: 0.999796533
p_ni: 0.000203468
Data Source: BioPlex
FBXO45
Tbio
Novelty: 0.05784607
p_int: 0.999685567
p_ni: 0.000305167
p_wrong: 0.000009266
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.90002893
p_ni: 0.09997107
Score: 0.157
Data Source: BioPlex,STRINGDB
EFNA5
Tbio
Novelty: 0.00134985
Score: 0.999
Data Source: STRINGDB
EFNB1
Tbio
Novelty: 0.00523161
Score: 0.997
Data Source: STRINGDB
EFNA1
Tbio
Family: Kinase
Novelty: 0.00732252
Score: 0.993
Data Source: STRINGDB
EFNA3
Tbio
Novelty: 0.01819539
Score: 0.993
Data Source: STRINGDB
EFNA2
Tbio
Novelty: 0.01184859
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  502.85

PubMed score by year
PubTator Score  379.27

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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