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Tchem
EPHA8
Ephrin type-A receptor 8

Protein Summary
Description
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000166244
  • ENSP00000166244
  • ENSG00000070886
  • ENST00000374644
  • ENSP00000363775

Symbol
  • EEK
  • HEK3
  • KIAA1459
  • EEK
  • EK3
  • HEK3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
cell type or tissue
0.72
biological process
0.69
gene perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.05   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.05   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (94)
EFNA5
Tbio
Novelty:  0.00134985
p_int:  0.999797375
p_ni:  0.000202533
p_wrong:  9.3e-8
Score:  0.995
Data Source:  BioPlex,STRINGDB
ENDOG
Tbio
Family:  Enzyme
Novelty:  0.00404275
p_int:  0.933094704
p_ni:  0.066905291
p_wrong:  5e-9
Score:  0.319
Data Source:  BioPlex,STRINGDB
EFNA1
Tbio
Family:  Kinase
Novelty:  0.00732252
Score:  0.995
Data Source:  STRINGDB
EFNA4
Tbio
Novelty:  0.03628159
Score:  0.995
Data Source:  STRINGDB
EFNA3
Tbio
Novelty:  0.01819539
Score:  0.993
Data Source:  STRINGDB
EFNB1
Tbio
Novelty:  0.00523161
Score:  0.993
Data Source:  STRINGDB
EFNB3
Tbio
Novelty:  0.0120367
Score:  0.993
Data Source:  STRINGDB
EFNA2
Tbio
Novelty:  0.01184859
Score:  0.993
Data Source:  STRINGDB
EFNB2
Tbio
Novelty:  0.00255095
Score:  0.992
Data Source:  STRINGDB
PIK3CG
Tclin
Family:  Kinase
Novelty:  0.00170533
Score:  0.948
Data Source:  STRINGDB
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
0
6.7
49.5
interferon gamma measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
0
6.7
49.5
interferon gamma measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A8
VGNC:532
456611
Macaque
EPH receptor A8
708378
Mouse
MGI:109378
13842
Rat
RGD:708543
60589
Dog
EPH receptor A8
VGNC:40410
487383
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A8
Macaque
EPH receptor A8
Mouse
Rat
Dog
EPH receptor A8
Publication Statistics
PubMed Score 42.05
PubMed score by year
PubTator Score 128.35
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title