Protein Classes
Protein Summary
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH a ...more
- ENST00000336596
- ENSP00000337451
- ENSG00000044524
- ENST00000452448
- ENSP00000399926
- ETK
- ETK1
- HEK
- TYRO4
- EK4
- ETK
- HEK
- ETK1
- HEK4
- TYRO4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.99 | ||
transcription factor perturbation | 0.94 | ||
microRNA | 0.93 | ||
gene perturbation | 0.8 | ||
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 228.46 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 457 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 228.46 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 457 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 12
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
Active Ligands (12)
1 – 10 of 12
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.1 | 53.7 | |||||
mathematical ability | 2 | 2 | 2 | 51.4 | |||||
intelligence | 2 | 3 | 0 | 5.6 | 44 | ||||
smoking behaviour measurement | 1 | 1 | 1 | 35 | |||||
tea consumption measurement | 2 | 1 | 2 | 35 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 53.7 | |||||
mathematical ability | 2 | 51.4 | |||||
intelligence | 0 | 5.6 | 44 | ||||
smoking behaviour measurement | 1 | 35 | |||||
tea consumption measurement | 2 | 35 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | EPH receptor A3 | VGNC:1809 | 460531 | |||||
Macaque | EPH receptor A3 | 694583 | ||||||
Mouse | MGI:99612 | 13837 | ||||||
Rat | RGD:68389 | 29210 | ||||||
Dog | EPH receptor A3 | VGNC:40406 | 487930 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | EPH receptor A3 | |||||
Macaque | EPH receptor A3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | EPH receptor A3 | |||||
Protein Structure (27 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 27
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (11)
Reactome (4)
KEGG (1)
PathwayCommons (4)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
Gene Ontology Terms (31)
Functions (5)
Components (7)
Processes (19)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (134)
1 – 10 of 134
EPHA7
Family: Kinase
Novelty: 0.01065563
p_int: 0.999935474
p_ni: 0.000064479
p_wrong: 4.7e-8
Score: 0.933
Data Source: BioPlex,STRINGDB
EFNA5
Novelty: 0.00134985
p_int: 0.999878385
p_ni: 0.000121615
Score: 0.999
Data Source: BioPlex,STRINGDB
LRRIQ1
Novelty: 1.8251367
p_int: 0.99128511
p_ni: 0.008713257
p_wrong: 0.000001632
Score: 0.554
Data Source: BioPlex,STRINGDB
FAM118B
Novelty: 0.48168976
p_int: 0.95513242
p_ni: 0.033751333
p_wrong: 0.011116247
Score: 0.165
Data Source: BioPlex,STRINGDB
SLAMF1
Novelty: 0.00112892
p_int: 0.946129735
p_ni: 0.041240495
p_wrong: 0.01262977
Score: 0.157
Data Source: BioPlex,STRINGDB
HLA-DRA
Novelty: 0.0060214
p_int: 0.881035982
p_ni: 0.091317198
p_wrong: 0.027646819
Score: 0.181
Data Source: BioPlex,STRINGDB
TMEM231
Novelty: 0.17100188
p_int: 0.781509957
p_ni: 0.193004433
p_wrong: 0.025485609
Score: 0.179
Data Source: BioPlex,STRINGDB
CEACAM21
Novelty: 0.46116153
p_int: 0.770190719
p_ni: 0.20593599
p_wrong: 0.02387329
Data Source: BioPlex
EFNB2
Novelty: 0.00255095
Score: 0.998
Data Source: STRINGDB
EFNB1
Novelty: 0.00523161
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score 228.46
PubMed score by year
PubTator Score 103.27
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Ortholog Sequence Conservation
PolarG S T Y C
NeutralQ N
BasicK R H
AcidicD E
HydrophobicA V L I P W F M
Find similar targets by:
UniProt Keyword
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GWAS Trait
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