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Tchem
EPHA3
Ephrin type-A receptor 3

Protein Summary
Description
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336596
  • ENSP00000337451
  • ENSG00000044524
  • ENST00000452448
  • ENSP00000399926

Symbol
  • ETK
  • ETK1
  • HEK
  • TYRO4
  • EK4
  • ETK
  • HEK
  • ETK1
  • HEK4
  • TYRO4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
transcription factor perturbation
0.94
microRNA
0.93
gene perturbation
0.8


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.46   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 457   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.46   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 457   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
bosutinib
Rendered image for bosutinib
dasatinib
Rendered image for dasatinib
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
53.7
mathematical ability
2
2
2
51.4
intelligence
2
3
0
5.6
44
smoking behaviour measurement
1
1
1
35
tea consumption measurement
2
1
2
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
53.7
mathematical ability
2
51.4
intelligence
0
5.6
44
smoking behaviour measurement
1
35
tea consumption measurement
2
35
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A3
VGNC:1809
460531
Macaque
EPH receptor A3
694583
Mouse
MGI:99612
13837
Rat
RGD:68389
29210
Dog
EPH receptor A3
VGNC:40406
487930
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A3
Macaque
EPH receptor A3
Mouse
Rat
Dog
EPH receptor A3
Protein Structure (27 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29320-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 27
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Gene Ontology Terms (31)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (134)
1 – 10 of 134
EPHA7
Tchem
Family:  Kinase
Novelty:  0.01065563
p_int:  0.999935474
p_ni:  0.000064479
p_wrong:  4.7e-8
Score:  0.933
Data Source:  BioPlex,STRINGDB
EFNA5
Tbio
Novelty:  0.00134985
p_int:  0.999878385
p_ni:  0.000121615
Score:  0.999
Data Source:  BioPlex,STRINGDB
LRRIQ1
Tdark
Novelty:  1.8251367
p_int:  0.99128511
p_ni:  0.008713257
p_wrong:  0.000001632
Score:  0.554
Data Source:  BioPlex,STRINGDB
FAM118B
Tdark
Novelty:  0.48168976
p_int:  0.95513242
p_ni:  0.033751333
p_wrong:  0.011116247
Score:  0.165
Data Source:  BioPlex,STRINGDB
SLAMF1
Tbio
Novelty:  0.00112892
p_int:  0.946129735
p_ni:  0.041240495
p_wrong:  0.01262977
Score:  0.157
Data Source:  BioPlex,STRINGDB
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.881035982
p_ni:  0.091317198
p_wrong:  0.027646819
Score:  0.181
Data Source:  BioPlex,STRINGDB
TMEM231
Tbio
Novelty:  0.17100188
p_int:  0.781509957
p_ni:  0.193004433
p_wrong:  0.025485609
Score:  0.179
Data Source:  BioPlex,STRINGDB
CEACAM21
Tdark
Novelty:  0.46116153
p_int:  0.770190719
p_ni:  0.20593599
p_wrong:  0.02387329
Data Source:  BioPlex
EFNB2
Tbio
Novelty:  0.00255095
Score:  0.998
Data Source:  STRINGDB
EFNB1
Tbio
Novelty:  0.00523161
Score:  0.995
Data Source:  STRINGDB
Publication Statistics
PubMed Score  228.46

PubMed score by year
PubTator Score  103.27

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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