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Tclin
EPHA2
Ephrin type-A receptor 2

Protein Summary
Description
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358432
  • ENSP00000351209
  • ENSG00000142627

Symbol
  • ECK
  • ECK
  • CTPA
  • ARCC2
  • CTPP1
  • CTRCT6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
PubMedID
0.98
biological process
0.95
interacting protein
0.85


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 668.5   (req: < 5)
Gene RIFs: 212   (req: <= 3)
Antibodies: 1179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 668.5   (req: >= 5)
Gene RIFs: 212   (req: > 3)
Antibodies: 1179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
bosutinib
chemical structure image
dasatinib
chemical structure image
Active Ligands (13)
1 – 10 of 13
CHEMBL1230609
chemical structure image
CHEMBL386051
chemical structure image
CHEMBL249097
chemical structure image
CHEMBL1784637
chemical structure image
CHEMBL566515
chemical structure image
DDR1/2 inhibitor 5n
chemical structure image
compound 20 [PMID: 23489211]
chemical structure image
CHEMBL2029988
chemical structure image
CHEMBL3426225
chemical structure image
CHEMBL478629
chemical structure image
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A2
VGNC:531
456472
Macaque
EPH receptor A2
692343
Mouse
MGI:95278
13836
Rat
RGD:1307204
366492
Dog
EPH receptor A2
VGNC:40405
487421
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A2
Macaque
EPH receptor A2
Mouse
Rat
Dog
EPH receptor A2
Protein Structure (58 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29317-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 58
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Gene Ontology Terms (64)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (276)
1 – 10 of 276
SDC1
Tbio
Novelty: 0.00044792
p_int: 0.998340724
p_ni: 0.001659276
Score: 0.414
Data Source: BioPlex,STRINGDB
EFNA5
Tbio
Novelty: 0.00134985
p_int: 0.997568562
p_ni: 0.002431438
Score: 0.999
Data Source: BioPlex,STRINGDB
CYP2S1
Tbio
Novelty: 0.02967417
p_int: 0.98670038
p_ni: 0.013299617
p_wrong: 3e-9
Score: 0.155
Data Source: BioPlex,STRINGDB
CCR1
Tchem
Family: GPCR
Novelty: 0.00218065
p_int: 0.930026402
p_ni: 0.069694096
p_wrong: 0.000279502
Score: 0.212
Data Source: BioPlex,STRINGDB
GJB7
Tbio
Novelty: 0.12555147
p_int: 0.923252667
p_ni: 0.076747331
p_wrong: 2e-9
Data Source: BioPlex
LRRIQ1
Tdark
Novelty: 1.8251367
p_int: 0.899352611
p_ni: 0.100394209
p_wrong: 0.00025318
Score: 0.194
Data Source: BioPlex,STRINGDB
NCSTN
Tbio
Novelty: 0.00453935
p_int: 0.868744829
p_ni: 0.131038183
p_wrong: 0.000216987
Data Source: BioPlex
NTRK3
Tclin
Family: Kinase
Novelty: 0.00177321
p_int: 0.851152407
p_ni: 0.14884376
p_wrong: 0.000003833
Score: 0.177
Data Source: BioPlex,STRINGDB
MAS1
Tchem
Family: GPCR
Novelty: 0.0089712
p_int: 0.842168969
p_ni: 0.157830376
p_wrong: 6.55e-7
Score: 0.154
Data Source: BioPlex,STRINGDB
SLC25A41
Tdark
Family: Transporter
Novelty: 1.04918395
p_int: 0.84216459
p_ni: 0.153363658
p_wrong: 0.004471752
Data Source: BioPlex
Publication Statistics
PubMed Score  668.50

PubMed score by year
PubTator Score  377.54

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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