Protein Summary
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development a ...more
- ENST00000358432
- ENSP00000351209
- ENSG00000142627
- ECK
- ECK
- CTPA
- ARCC2
- CTPP1
- CTRCT6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.98 | ||
PubMedID | 0.98 | ||
biological process | 0.95 | ||
interacting protein | 0.85 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 987.82 (req: < 5)
Gene RIFs: 212 (req: <= 3)
Antibodies: 1179 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 987.82 (req: >= 5)
Gene RIFs: 212 (req: > 3)
Antibodies: 1179 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 52
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 13
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
Active Ligands (13)
1 – 10 of 13
Protein Data Bank (58)
1 – 5 of 58
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (30)
Reactome (4)
KEGG (5)
PathwayCommons (7)
WikiPathways (14)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
Gene Ontology Terms (64)
Functions (6)
Components (12)
Processes (46)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (276)
1 – 10 of 276
SDC1
Novelty: 0.0006457
p_int: 0.998340724
p_ni: 0.001659276
Score: 0.414
Data Source: BioPlex,STRINGDB
EFNA5
Novelty: 0.00173565
p_int: 0.997568562
p_ni: 0.002431438
Score: 0.999
Data Source: BioPlex,STRINGDB
CYP2S1
Novelty: 0.04038753
p_int: 0.98670038
p_ni: 0.013299617
p_wrong: 3e-9
Score: 0.155
Data Source: BioPlex,STRINGDB
CCR1
Family: GPCR
Novelty: 0.00293956
p_int: 0.930026402
p_ni: 0.069694096
p_wrong: 0.000279502
Score: 0.212
Data Source: BioPlex,STRINGDB
GJB7
Novelty: 0.28301887
p_int: 0.923252667
p_ni: 0.076747331
p_wrong: 2e-9
Data Source: BioPlex
LRRIQ1
p_int: 0.899352611
p_ni: 0.100394209
p_wrong: 0.00025318
Score: 0.194
Data Source: BioPlex,STRINGDB
NCSTN
Novelty: 0.00628726
p_int: 0.868744829
p_ni: 0.131038183
p_wrong: 0.000216987
Data Source: BioPlex
NTRK3
Family: Kinase
Novelty: 0.00241438
p_int: 0.851152407
p_ni: 0.14884376
p_wrong: 0.000003833
Score: 0.177
Data Source: BioPlex,STRINGDB
MAS1
Family: GPCR
Novelty: 0.00884994
p_int: 0.842168969
p_ni: 0.157830376
p_wrong: 6.55e-7
Score: 0.154
Data Source: BioPlex,STRINGDB
SLC25A41
Family: Transporter
Novelty: 2.02597403
p_int: 0.84216459
p_ni: 0.153363658
p_wrong: 0.004471752
Data Source: BioPlex
Publication Statistics
PubMed Score 987.82
PubMed score by year
PubTator Score 377.54
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Ortholog Sequence Conservation
PolarG S T Y C
NeutralQ N
BasicK R H
AcidicD E
HydrophobicA V L I P W F M
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GWAS Trait