Protein Summary
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development a ...more
- ENST00000358432
- ENSP00000351209
- ENSG00000142627
- ECK
- ECK
- CTPA
- ARCC2
- CTPP1
- CTRCT6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
molecular function | 0.98 | ||
PubMedID | 0.98 | ||
biological process | 0.95 | ||
interacting protein | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 712.61 (req: < 5)
Gene RIFs: 212 (req: <= 3)
Antibodies: 1179 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 712.61 (req: >= 5)
Gene RIFs: 212 (req: > 3)
Antibodies: 1179 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 52
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 47
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (47)
Protein-Protein Interactions (276)
SDC1
Novelty: 0.00044792
p_int: 0.998340724
p_ni: 0.001659276
Score: 0.414
Data Source: BioPlex,STRINGDB
EFNA5
Novelty: 0.00134985
p_int: 0.997568562
p_ni: 0.002431438
Score: 0.999
Data Source: BioPlex,STRINGDB
CYP2S1
Novelty: 0.02967417
p_int: 0.98670038
p_ni: 0.013299617
p_wrong: 3e-9
Score: 0.155
Data Source: BioPlex,STRINGDB
CCR1
Family: GPCR
Novelty: 0.00218065
p_int: 0.930026402
p_ni: 0.069694096
p_wrong: 0.000279502
Score: 0.212
Data Source: BioPlex,STRINGDB
LRRIQ1
Novelty: 1.8251367
p_int: 0.899352611
p_ni: 0.100394209
p_wrong: 0.00025318
Score: 0.194
Data Source: BioPlex,STRINGDB
NCSTN
Novelty: 0.00453935
p_int: 0.868744829
p_ni: 0.131038183
p_wrong: 0.000216987
Data Source: BioPlex
NTRK3
Family: Kinase
Novelty: 0.00177321
p_int: 0.851152407
p_ni: 0.14884376
p_wrong: 0.000003833
Score: 0.177
Data Source: BioPlex,STRINGDB
MAS1
Family: GPCR
Novelty: 0.0089712
p_int: 0.842168969
p_ni: 0.157830376
p_wrong: 6.55e-7
Score: 0.154
Data Source: BioPlex,STRINGDB
SLC25A41
Family: Transporter
Novelty: 1.04918395
p_int: 0.84216459
p_ni: 0.153363658
p_wrong: 0.004471752
Data Source: BioPlex
Nearest Tclin Targets
Pathways (30)
Reactome (4)
KEGG (5)
PathwayCommons (7)
WikiPathways (14)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
Viral Interactions (0)
Gene Ontology Terms (64)
Functions (6)
Components (12)
Processes (46)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 5 | 15 | 16 | 3.8 | 99.9 | ||||
hematocrit | 2 | 2 | 2 | 90 | |||||
hemoglobin measurement | 2 | 2 | 2 | 89.1 | |||||
low density lipoprotein cholesterol measurement | 5 | 3 | 5 | 88.3 | |||||
aspartate aminotransferase measurement | 2 | 2 | 1 | 13.2 | 83.6 | ||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 16 | 3.8 | 99.9 | ||||
hematocrit | 2 | 90 | |||||
hemoglobin measurement | 2 | 89.1 | |||||
low density lipoprotein cholesterol measurement | 5 | 88.3 | |||||
aspartate aminotransferase measurement | 1 | 13.2 | 83.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | EPH receptor A2 | VGNC:531 | 456472 | |||||
Macaque | EPH receptor A2 | 692343 | ||||||
Mouse | MGI:95278 | 13836 | ||||||
Rat | RGD:1307204 | 366492 | ||||||
Dog | EPH receptor A2 | VGNC:40405 | 487421 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | EPH receptor A2 | |||||
Macaque | EPH receptor A2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | EPH receptor A2 | |||||
Publication Statistics
PubMed Score 712.61
PubMed score by year
PubTator Score 377.54
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (256)
GeneRif Annotations (212)
Items per page:
0 of 0
PMID | Year | Title |
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