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Tclin
EPHA2
Ephrin type-A receptor 2

Protein Summary
Description
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358432
  • ENSP00000351209
  • ENSG00000142627

Symbol
  • ECK
  • ECK
  • CTPA
  • ARCC2
  • CTPP1
  • CTRCT6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
PubMedID
0.98
biological process
0.95
interacting protein
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 821.74   (req: < 5)
Gene RIFs: 212   (req: <= 3)
Antibodies: 1179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 821.74   (req: >= 5)
Gene RIFs: 212   (req: > 3)
Antibodies: 1179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (276)
SDC1
Tbio
Novelty:  0.00044792
p_int:  0.998340724
p_ni:  0.001659276
Score:  0.414
Data Source:  BioPlex,STRINGDB
EFNA5
Tbio
Novelty:  0.00134985
p_int:  0.997568562
p_ni:  0.002431438
Score:  0.999
Data Source:  BioPlex,STRINGDB
CYP2S1
Tbio
Novelty:  0.02967417
p_int:  0.98670038
p_ni:  0.013299617
p_wrong:  3e-9
Score:  0.155
Data Source:  BioPlex,STRINGDB
CCR1
Tchem
Family:  GPCR
Novelty:  0.00218065
p_int:  0.930026402
p_ni:  0.069694096
p_wrong:  0.000279502
Score:  0.212
Data Source:  BioPlex,STRINGDB
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.923252667
p_ni:  0.076747331
p_wrong:  2e-9
Data Source:  BioPlex
LRRIQ1
Tdark
Novelty:  1.8251367
p_int:  0.899352611
p_ni:  0.100394209
p_wrong:  0.00025318
Score:  0.194
Data Source:  BioPlex,STRINGDB
NCSTN
Tbio
Novelty:  0.00453935
p_int:  0.868744829
p_ni:  0.131038183
p_wrong:  0.000216987
Data Source:  BioPlex
NTRK3
Tclin
Family:  Kinase
Novelty:  0.00177321
p_int:  0.851152407
p_ni:  0.14884376
p_wrong:  0.000003833
Score:  0.177
Data Source:  BioPlex,STRINGDB
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.842168969
p_ni:  0.157830376
p_wrong:  6.55e-7
Score:  0.154
Data Source:  BioPlex,STRINGDB
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.84216459
p_ni:  0.153363658
p_wrong:  0.004471752
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (30)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (64)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
7
15
18
3.8
99.8
low density lipoprotein cholesterol measurement
5
3
5
92.4
aspartate aminotransferase measurement
2
2
1
13.2
84.6
hematocrit
3
3
3
83.9
hemoglobin measurement
3
3
3
82.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
18
3.8
99.8
low density lipoprotein cholesterol measurement
5
92.4
aspartate aminotransferase measurement
1
13.2
84.6
hematocrit
3
83.9
hemoglobin measurement
3
82.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A2
VGNC:531
456472
Macaque
EPH receptor A2
692343
Mouse
MGI:95278
13836
Rat
RGD:1307204
366492
Dog
EPH receptor A2
VGNC:40405
487421
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A2
Macaque
EPH receptor A2
Mouse
Rat
Dog
EPH receptor A2
Publication Statistics
PubMed Score 821.74
PubMed score by year
PubTator Score 377.54
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title