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Tbio
CTGF
Connective tissue growth factor

Protein Summary
Description
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367976
  • ENSP00000356954
  • ENSG00000118523

Symbol
  • CCN2
  • HCS24
  • IGFBP8
  • CTGF
  • NOV2
  • HCS24
  • IGFBP8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
PubMedID
1
protein domain
0.97
small molecule perturbation
0.97


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2736.86   (req: < 5)
Gene RIFs: 462   (req: <= 3)
Antibodies: 852   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2736.86   (req: >= 5)
Gene RIFs: 462   (req: > 3)
Antibodies: 852   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
connective tissue growth factor
714520
Mouse
MGI:95537
14219
Rat
RGD:621392
64032
Dog
connective tissue growth factor
VGNC:39696
476202
Horse
connective tissue growth factor
VGNC:16934
100073098
Species
Name
OMA
EggNOG
Inparanoid
Macaque
connective tissue growth factor
Mouse
Rat
Dog
connective tissue growth factor
Horse
connective tissue growth factor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P29279-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX3 regulates YAP1-mediated transcription
Reactome
Transcriptional regulation by RUNX3
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX3 regulates YAP1-mediated transcription
Transcriptional regulation by RUNX3
Gene Ontology Terms (57)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (281)
1 – 10 of 281
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
p_int: 0.999999842
p_ni: 1.58e-7
Score: 0.462
Data Source: BioPlex,STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
p_int: 0.999958325
p_ni: 0.000041675
Score: 0.351
Data Source: BioPlex,STRINGDB
TRIM68
Tbio
Family: Enzyme
Novelty: 0.11729189
p_int: 0.999817696
p_ni: 0.000182304
Score: 0.185
Data Source: BioPlex,STRINGDB
FZR1
Tbio
Novelty: 0.01599606
p_int: 0.999634345
p_ni: 0.000155295
p_wrong: 0.000210361
Data Source: BioPlex
KLHL23
Tdark
Novelty: 0.64141058
p_int: 0.96826604
p_ni: 0.031726032
p_wrong: 0.000007928
Score: 0.158
Data Source: BioPlex,STRINGDB
COA7
Tbio
Family: Enzyme
Novelty: 0.08512811
p_int: 0.828624399
p_ni: 0.171375601
Score: 0.252
Data Source: BioPlex,STRINGDB
LRP2
Tbio
Novelty: 0.00143258
p_int: 0.818028908
p_ni: 0.181971092
Score: 0.353
Data Source: BioPlex,STRINGDB
ARIH1
Tbio
Family: Enzyme
Novelty: 0.0258739
p_int: 0.760378977
p_ni: 0.239183242
p_wrong: 0.00043778
Data Source: BioPlex
TGFB1
Tchem
Novelty: 0.0001299
Score: 0.989
Data Source: STRINGDB
YAP1
Tbio
Novelty: 0.00124225
Score: 0.988
Data Source: STRINGDB
Publication Statistics
PubMed Score  2736.86

PubMed score by year
PubTator Score  998.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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