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Tclin
ADORA2B
Adenosine receptor A2b

Protein Summary
Description
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304222
  • ENSP00000304501
  • ENSG00000170425

Symbol
  • ADORA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
biological process
0.99
transcription factor perturbation
0.94
PubMedID
0.81
biological term
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1305.46   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1305.46   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1207
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8