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Tclin
ADORA2B
Adenosine receptor A2b

Protein Summary
Description
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304222
  • ENSP00000304501
  • ENSG00000170425

Symbol
  • ADORA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
biological process
0.99
transcription factor perturbation
0.94
PubMedID
0.81
biological term
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1151.77   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1151.77   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1192
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (218)
1 – 10 of 218
P2RY11
Tchem
Family:  GPCR
Novelty:  0.01380362
Score:  0.953
Data Source:  STRINGDB
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
Score:  0.941
Data Source:  STRINGDB
ADCY7
Tbio
Family:  Enzyme
Novelty:  0.00984562
Score:  0.941
Data Source:  STRINGDB
ADCY2
Tbio
Family:  Enzyme
Novelty:  0.01649836
Score:  0.939
Data Source:  STRINGDB
ADCY8
Tchem
Family:  Enzyme
Novelty:  0.00510386
Score:  0.936
Data Source:  STRINGDB
ADCY4
Tbio
Family:  Enzyme
Novelty:  0.00465974
Score:  0.936
Data Source:  STRINGDB
ADCY5
Tchem
Family:  Enzyme
Novelty:  0.00307839
Score:  0.935
Data Source:  STRINGDB
ADCY1
Tchem
Family:  Enzyme
Novelty:  0.01089602
Score:  0.935
Data Source:  STRINGDB
GNAS
Tbio
Novelty:  0.00284739
Score:  0.934
Data Source:  STRINGDB
GNAS
Tbio
Novelty:  0.00284739
Score:  0.934
Data Source:  STRINGDB
Pathways (31)
Adenosine P1 receptors (R-HSA-417973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adenosine P1 receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Adenosine P1 receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (23)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
1
2
57.3
body height
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
57.3
body height
1
29
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenosine A2b receptor
VGNC:9120
455009
Mouse
MGI:99403
11541
Rat
RGD:2050
29316
Dog
adenosine A2b receptor
VGNC:37667
403410
Horse
adenosine A2b receptor
VGNC:15127
100063319
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenosine A2b receptor
Mouse
Rat
Dog
adenosine A2b receptor
Horse
adenosine A2b receptor
Publication Statistics
PubMed Score 1151.77
PubMed score by year
PubTator Score 45.19
PubTator score by year
Patents
Patents by year