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Tclin
ADORA2A
Adenosine receptor A2a

Protein Summary
Description
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337539
  • ENSP00000336630
  • ENSG00000128271
  • ENST00000610595
  • ENSP00000480012
  • ENST00000611543
  • ENSP00000483102
  • ENST00000618076
  • ENSP00000481552

Symbol
  • ADORA2
  • A2aR
  • RDC8
  • ADORA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
biological process
0.92
phenotype
0.87
disease
0.84
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2666.38   (req: < 5)
Gene RIFs: 258   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2666.38   (req: >= 5)
Gene RIFs: 258   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 58
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1608
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tea consumption measurement
1
1
1
48
alcohol consumption measurement
1
1
1
44.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tea consumption measurement
1
48
alcohol consumption measurement
1
44.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenosine A2a receptor
VGNC:5238
458714
Macaque
adenosine A2a receptor
707865
Mouse
MGI:99402
11540
Rat
RGD:2049
25369
Dog
adenosine A2a receptor
VGNC:37666
403960
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenosine A2a receptor
Macaque
adenosine A2a receptor
Mouse
Rat
Dog
adenosine A2a receptor
Protein Structure (47 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29274-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 47
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (46)
Activation of TRKA receptors (R-HSA-187015)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of TRKA receptors
Reactome
Adenosine P1 receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Activation of TRKA receptors
Adenosine P1 receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
Gene Ontology Terms (71)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (96)
1 – 10 of 96
GNG2
Tbio
Novelty: 0.04807242
Score: 0.884
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.834
Data Source: STRINGDB
ADORA2B
Tclin
Family: GPCR
Novelty: 0.00096284
Score: 0.808
Data Source: STRINGDB
ADA
Tclin
Family: Enzyme
Novelty: 0.00072339
Score: 0.79
Data Source: STRINGDB
ENTPD1
Tchem
Family: Enzyme
Novelty: 0.00139367
Score: 0.749
Data Source: STRINGDB
NT5E
Tchem
Family: Enzyme
Novelty: 0.00083237
Score: 0.73
Data Source: STRINGDB
GDNF
Tbio
Novelty: 0.00036702
Score: 0.715
Data Source: STRINGDB
CREB1
Tbio
Family: TF
Novelty: 0.00018059
Score: 0.698
Data Source: STRINGDB
TRIM33
Tbio
Family: Epigenetic
Novelty: 0.00415877
Score: 0.698
Data Source: STRINGDB
BDNF
Tbio
Novelty: 0.00006891
Score: 0.686
Data Source: STRINGDB
Publication Statistics
PubMed Score  2666.38

PubMed score by year
PubTator Score  604.11

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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