You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
IMPA1
Inositol monophosphatase 1

Protein Summary
Description
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glyce ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256108
  • ENSP00000256108
  • ENSG00000133731
  • ENST00000311489
  • ENSP00000311803
  • ENST00000449740
  • ENSP00000408526

Symbol
  • IMPA
  • IMP
  • IMPA
  • MRT59
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
histone modification site profile
0.89
molecular function
0.81
co-expressed gene
0.79
tissue
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.32   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.32   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Active Ligands (1)
1 – 1 of 1
Li<sup>+</sup>
no chemical structure image available
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol monophosphatase 1
VGNC:12290
100613673
Macaque
inositol monophosphatase 1
701959
Mouse
MGI:1933158
55980
Rat
RGD:69254
83523
Dog
inositol monophosphatase 1
VGNC:42007
477925
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol monophosphatase 1
Macaque
inositol monophosphatase 1
Mouse
Rat
Dog
inositol monophosphatase 1
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29218-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (28)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP2, IP, and Ins in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP2, IP, and Ins in the cytosol
Gene Ontology Terms (18)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (78)
1 – 10 of 78
IMPA2
Tbio
Family: Enzyme
Novelty: 0.03983031
Score: 0.985
Data Source: STRINGDB
ISYNA1
Tbio
Family: Enzyme
Novelty: 0.00302974
Score: 0.975
Data Source: STRINGDB
INPP1
Tbio
Family: Enzyme
Novelty: 0.05426301
Score: 0.96
Data Source: STRINGDB
MIOX
Tbio
Family: Enzyme
Novelty: 0.00962281
Score: 0.953
Data Source: STRINGDB
IMPAD1
Tbio
Family: Enzyme
Novelty: 0.08211251
Score: 0.951
Data Source: STRINGDB
CDIPT
Tbio
Family: Enzyme
Novelty: 0.00560887
Score: 0.929
Data Source: STRINGDB
MTM1
Tbio
Family: Enzyme
Novelty: 0.00413329
Score: 0.909
Data Source: STRINGDB
INPP4A
Tbio
Family: Enzyme
Novelty: 0.03714963
Score: 0.908
Data Source: STRINGDB
INPP4B
Tbio
Family: Enzyme
Novelty: 0.02053228
Score: 0.9
Data Source: STRINGDB
PGLS
Tbio
Family: Enzyme
Novelty: 0.03252394
Score: 0.872
Data Source: STRINGDB
Publication Statistics
PubMed Score  123.32

PubMed score by year
PubTator Score  178.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer