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Tchem
TPP2
Tripeptidyl-peptidase 2

Protein Summary
Description
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity). This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376065
  • ENSP00000365233
  • ENSG00000134900

Symbol
  • TPP-2
  • TPPII
  • TPP-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
kinase perturbation
0.88
transcription factor perturbation
0.84
disease perturbation
0.83
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.17   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.17   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
72.3
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripeptidyl peptidase 2
VGNC:9825
452645
Macaque
tripeptidyl peptidase 2
701311
Mouse
MGI:102724
22019
Rat
RGD:621584
81815
Dog
tripeptidyl peptidase 2
VGNC:47748
100855853
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripeptidyl peptidase 2
Macaque
tripeptidyl peptidase 2
Mouse
Rat
Dog
tripeptidyl peptidase 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P29144-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (53)
1 – 10 of 53
RALB
Tbio
Family: Enzyme
Novelty: 0.01605746
p_int: 0.999999992
p_ni: 8e-9
Score: 0.242
Data Source: BioPlex,STRINGDB
DOK3
Tbio
Novelty: 0.06212348
p_int: 0.999967881
p_ni: 0.000032119
Score: 0.196
Data Source: BioPlex,STRINGDB
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
p_int: 0.999904353
p_ni: 0.000095647
Data Source: BioPlex
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.999858894
p_ni: 0.000141106
Data Source: BioPlex
ANKRD39
Tdark
Novelty: 8.68843298
p_int: 0.998848278
p_ni: 0.00115172
p_wrong: 2e-9
Data Source: BioPlex
GTF2E2
Tbio
Novelty: 0.18033153
p_int: 0.998446412
p_ni: 0.001553535
p_wrong: 5.3e-8
Data Source: BioPlex
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.994681352
p_ni: 0.005318567
p_wrong: 8.1e-8
Data Source: BioPlex
PCDHGB4
Tdark
Novelty: 0.25018904
p_int: 0.994485171
p_ni: 0.005514663
p_wrong: 1.66e-7
Data Source: BioPlex
CYP1A1
Tchem
Novelty: 0.0002404
p_int: 0.992125231
p_ni: 0.007874768
p_wrong: 1e-9
Data Source: BioPlex
NAA40
Tbio
Family: Enzyme
Novelty: 0.13882523
p_int: 0.987194159
p_ni: 0.01280584
Score: 0.212
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  142.17

PubMed score by year
PubTator Score  96.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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