Pharos: Illuminating the Druggable Genome

Tchem

Protein Classes

Protein Summary

Description

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which ...more

Uniprot Accession IDs

Gene Name

PCSK6

Ensembl ID

ENST00000611716
ENSP00000482760
ENSG00000140479
ENST00000611967
ENSP00000477768
ENST00000615296
ENSP00000478081
ENST00000618548
ENSP00000479496

Symbol

PACE4
SPC4
PACE4

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1

disease perturbation	0.87

transcription factor perturbation	0.84

PubMedID	0.8

cellular component	0.77

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.57 (req: < 5)

View Publications

Gene RIFs: 33 (req: <= 3)

View Gene RIFs

Antibodies: 300 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.57 (req: >= 5)

Gene RIFs: 33 (req: > 3)

Antibodies: 300 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (8)

1 – 8 of 8

Pathways (15)

Reactome (13)

PathwayCommons (2)

Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

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Items per page:

1 – 5 of 13

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Assembly of active LPL and LIPC lipase complexes	19 targets	R-HSA-8963889

Reactome	Developmental Biology	1055 targets	R-HSA-1266738

Reactome	Expression and Processing of Neurotrophins	4 targets	R-HSA-9036866

Reactome	Formation of the cornified envelope	75 targets	R-HSA-6809371

Reactome	Keratinization	217 targets	R-HSA-6805567

Name	Explore in Pharos	Explore in Source
Assembly of active LPL and LIPC lipase complexes	19 targets	R-HSA-8963889

Developmental Biology	1055 targets	R-HSA-1266738

Expression and Processing of Neurotrophins	4 targets	R-HSA-9036866

Formation of the cornified envelope	75 targets	R-HSA-6809371

Keratinization	217 targets	R-HSA-6805567

Gene Ontology Terms (21)

Functions (4)

Components (7)

Processes (10)

Items per page:

1 – 4 of 4

GO Term	Evidence	Assigned by
endopeptidase activity	Inferred from Direct Assay (IDA)	BHF-UCL

heparin binding	Inferred from Direct Assay (IDA)	BHF-UCL

nerve growth factor binding	Inferred from Direct Assay (IDA)	BHF-UCL

serine-type endopeptidase activity	Inferred from Direct Assay (IDA)	BHF-UCL

Protein-Protein Interactions (40)

1 – 10 of 40

See Interactions on String-DB

TMEM25

Tdark

Novelty: 0.57954545

p_int: 0.760590849

p_ni: 0.239409151

Score: 0.243

Data Source: BioPlex,STRINGDB

NODAL

Tbio

Novelty: 0.01417238

Score: 0.942