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Tchem
PCSK6
Proprotein convertase subtilisin/kexin type 6

Protein Summary
Description
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000611716
  • ENSP00000482760
  • ENSG00000140479
  • ENST00000611967
  • ENSP00000477768
  • ENST00000615296
  • ENSP00000478081
  • ENST00000618548
  • ENSP00000479496

Symbol
  • PACE4
  • SPC4
  • PACE4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.87
transcription factor perturbation
0.84
PubMedID
0.8
cellular component
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.43   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.43   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet-derived growth factor BB measurement
2
2
2
86
2
2
2
71.9
handedness
2
2
2
71.9
low density lipoprotein cholesterol measurement
1
1
1
63.7
triglyceride measurement
2
2
2
49.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet-derived growth factor BB measurement
2
86
2
71.9
handedness
2
71.9
low density lipoprotein cholesterol measurement
1
63.7
triglyceride measurement
2
49.2
Pathways (15)
Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Developmental Biology
Reactome
Expression and Processing of Neurotrophins
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Assembly of active LPL and LIPC lipase complexes
Developmental Biology
Expression and Processing of Neurotrophins
Formation of the cornified envelope
Keratinization
Protein-Protein Interactions (40)
1 – 10 of 40
TMEM25
Tdark
Novelty: 0.35505784
p_int: 0.760590849
p_ni: 0.239409151
Score: 0.243
Data Source: BioPlex,STRINGDB
NODAL
Tbio
Novelty: 0.01033642
Score: 0.942
Data Source: Reactome,STRINGDB
FLG
Tbio
Novelty: 0.00072986
Score: 0.936
Data Source: Reactome,STRINGDB
NGF
Tchem
Novelty: 0.00008139
Score: 0.915
Data Source: Reactome,STRINGDB
LPL
Tchem
Family: Enzyme
Novelty: 0.00057058
Score: 0.91
Data Source: Reactome,STRINGDB
GPIHBP1
Tbio
Novelty: 0.01241227
Score: 0.907
Data Source: Reactome,STRINGDB
KRT6B
Tbio
Novelty: 0.00152754
Score: 0.787
Data Source: STRINGDB
LRRTM1
Tbio
Novelty: 0.0409182
Score: 0.77
Data Source: STRINGDB
PCSK9
Tclin
Family: Enzyme
Novelty: 0.00030553
Score: 0.728
Data Source: STRINGDB
SCG5
Tbio
Novelty: 0.00379377
Score: 0.693
Data Source: STRINGDB
Publication Statistics
PubMed Score  274.43

PubMed score by year
PubTator Score  93.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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