PCSK6
Proprotein convertase subtilisin/kexin type 6
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
disease perturbation | 0.87 | ||
transcription factor perturbation | 0.84 | ||
PubMedID | 0.8 | ||
cellular component | 0.77 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Assembly of active LPL and LIPC lipase complexes | ||||
Reactome | Developmental Biology | ||||
Reactome | Expression and Processing of Neurotrophins | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Assembly of active LPL and LIPC lipase complexes | ||||
Developmental Biology | ||||
Expression and Processing of Neurotrophins | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
platelet-derived growth factor BB measurement | 2 | 3 | 3 | 88.3 | |||||
neutrophil count | 1 | 1 | 1 | 83.1 | |||||
triglyceride measurement | 4 | 5 | 5 | 79.2 | |||||
basophil count | 2 | 2 | 2 | 79.2 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 77.6 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
platelet-derived growth factor BB measurement | 3 | 88.3 | |||||
neutrophil count | 1 | 83.1 | |||||
triglyceride measurement | 5 | 79.2 | |||||
basophil count | 2 | 79.2 | |||||
neutrophil percentage of leukocytes | 1 | 77.6 | |||||
PMID | Year | Title |
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