Pharos : Target Details

Tchem

Protein Summary

Description

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which ...more

Uniprot Accession IDs

Gene Name

PCSK6

Ensembl ID

ENST00000611716
ENSP00000482760
ENSG00000140479
ENST00000611967
ENSP00000477768
ENST00000615296
ENSP00000478081
ENST00000618548
ENSP00000479496

Symbol

PACE4
SPC4
PACE4

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1

disease perturbation	0.87

transcription factor perturbation	0.84

PubMedID	0.8

cellular component	0.77

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.82 (req: < 5)

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Gene RIFs: 33 (req: <= 3)

View Gene RIFs

Antibodies: 300 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.82 (req: >= 5)

Gene RIFs: 33 (req: > 3)

Antibodies: 300 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 119

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (119)

Explore Active Ligands

1 – 10 of 119

CHEMBL3126388

CHEMBL568525

phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide

Protein-Protein Interactions (40)

Explore Interacting Targets

1 – 10 of 40

See Interactions on String-DB

TMEM25

Tdark

Novelty: 0.35505784

p_int: 0.760590849

p_ni: 0.239409151

Score: 0.243

Data Source: BioPlex,STRINGDB

NODAL

Tbio

Novelty: 0.01033642

Score: 0.942