Tchem PCSK1 Neuroendocrine convertase 1

Protein Summary

Description

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• P29120
• B7Z8T7
• E9PHA1
• P78478
• Q92532
• NEC 1

Gene Name

• PCSK1

Ensembl ID

• ENST00000311106
• ENSP00000308024
• ENSG00000175426
• ENST00000508626
• ENSP00000421600

Symbol

• NEC1
• PC1
• PC3
• NEC1
• SPC3
• BMIQ12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
biological term	0.62
cell type or tissue	0.62
gene perturbation	0.61
cellular component	0.6

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Neuroendocrine Convertase 1

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Neuroendocrine Convertase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 376.14   (req: < 5)

Gene RIFs: 69   (req: <= 3)

Antibodies: 166   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 376.14   (req: >= 5)

Gene RIFs: 69   (req: > 3)

Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0