GTF2E1
General transcription factor IIE subunit 1
Protein Summary
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
- ENST00000283875
- ENSP00000283875
- ENSG00000153767
- TF2E1
- FE
- TF2E1
- TFIIE-A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.92 | ||
kinase perturbation | 0.88 | ||
protein domain | 0.85 | ||
virus perturbation | 0.83 | ||
disease perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.9 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 185 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.9 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 185 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (210)
GTF2E2
Novelty: 0.18033153
p_int: 0.999999996
p_ni: 4e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SLC45A2
Family: Transporter
Novelty: 0.00268252
p_int: 0.798502479
p_ni: 0.200496194
p_wrong: 0.001001327
Score: 0.297
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (21)
Reactome (16)
KEGG (2)
PathwayCommons (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | HIV Infection | ||||
Reactome | HIV Life Cycle | ||||
Reactome | HIV Transcription Initiation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Disease | ||||
Gene expression (Transcription) | ||||
HIV Infection | ||||
HIV Life Cycle | ||||
HIV Transcription Initiation | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (4)
Components (6)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | general transcription factor IIE subunit 1 | VGNC:11976 | 460615 | |||||
Macaque | general transcription factor IIE subunit 1 | 713562 | ||||||
Mouse | MGI:1921447 | 74197 | ||||||
Rat | RGD:1306851 | 303918 | ||||||
Dog | general transcription factor IIE subunit 1 | VGNC:41544 | 488002 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | general transcription factor IIE subunit 1 | |||||
Macaque | general transcription factor IIE subunit 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | general transcription factor IIE subunit 1 | |||||
Publication Statistics
PubMed Score 2.90
PubMed score by year
PubTator Score 12.88
PubTator score by year
Related Publications
Text Mined References (45)
GeneRif Annotations (10)
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