Tbio GTF2E1 General transcription factor IIE subunit 1

Protein Summary

Description

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

Uniprot Accession IDs

• P29083
• Q16103

Gene Name

• GTF2E1

Ensembl ID

• ENST00000283875
• ENSP00000283875
• ENSG00000153767

Symbol

• TF2E1
• FE
• TF2E1
• TFIIE-A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
kinase perturbation	0.88
protein domain	0.85
virus perturbation	0.83
disease perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.9   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 185   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.9   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0