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Tbio
PTPN4
Tyrosine-protein phosphatase non-receptor type 4

Protein Summary
Description
May act at junctions between the membrane and the cytoskeleton. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263708
  • ENSP00000263708
  • ENSG00000088179

Symbol
  • MEG
  • PTPMEG
  • PTPMEG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
0.79
transcription factor binding site profile
0.76
tissue sample
0.65
hub protein
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.68   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.68   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
72.1
monocyte count
1
1
1
36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
72.1
monocyte count
1
36
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 4
VGNC:14346
470521
Macaque
protein tyrosine phosphatase, non-receptor type 4
695516
Mouse
MGI:1099792
19258
Rat
RGD:620712
246116
Dog
protein tyrosine phosphatase, non-receptor type 4
VGNC:45177
483882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 4
Macaque
protein tyrosine phosphatase, non-receptor type 4
Mouse
Rat
Dog
protein tyrosine phosphatase, non-receptor type 4
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29074-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Innate Immune System
Protein-Protein Interactions (40)
1 – 10 of 40
KCTD17
Tbio
Novelty: 0.12105733
p_int: 0.999722439
p_ni: 0.000001401
p_wrong: 0.00027616
Score: 0.212
Data Source: BioPlex,STRINGDB
GRIN2A
Tclin
Family: IC
Novelty: 0.00060035
Score: 0.915
Data Source: STRINGDB
TICAM2
Tbio
Novelty: 0.04205084
Score: 0.908
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.901
Data Source: STRINGDB
IL37
Tbio
Novelty: 0.00499186
Score: 0.9
Data Source: STRINGDB
GRID2
Tbio
Family: IC
Novelty: 0.00628904
Score: 0.798
Data Source: STRINGDB
TAAR1
Tclin
Family: GPCR
Novelty: 0.0018424
Score: 0.744
Data Source: STRINGDB
PTS
Tbio
Family: Enzyme
Novelty: 0.00279396
Score: 0.727
Data Source: STRINGDB
NBEAL1
Tbio
Novelty: 0.22337499
Score: 0.662
Data Source: STRINGDB
MTMR4
Tbio
Family: Enzyme
Novelty: 0.09166984
Score: 0.656
Data Source: STRINGDB
Publication Statistics
PubMed Score  38.68

PubMed score by year
PubTator Score  1513.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer