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Tbio
S100A2
Protein S100-A2

Protein Summary
Description
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368708
  • ENSP00000357697
  • ENSG00000196754
  • ENST00000368709
  • ENSP00000357698
  • ENST00000368710
  • ENSP00000357699
  • ENST00000487430
  • ENSP00000473260

Symbol
  • S100L
  • CAN19
  • S100L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.92
small molecule perturbation
0.76
protein domain
0.73
tissue sample
0.66
biological term
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.01   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.01   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (58)
1 – 10 of 58
CFAP97D1
Tdark
Novelty:  1.4689332
p_int:  0.92876697
p_ni:  0.000102036
p_wrong:  0.071130994
Score:  0.323
Data Source:  BioPlex,STRINGDB
FOXP2
Tbio
Family:  TF
Novelty:  0.00190504
p_int:  0.90688921
p_ni:  0.000610079
p_wrong:  0.092500712
Score:  0.243
Data Source:  BioPlex,STRINGDB
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.867294825
p_ni:  0.000113508
p_wrong:  0.132591667
Score:  0.175
Data Source:  BioPlex,STRINGDB
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  0.786333284
p_ni:  0.000066032
p_wrong:  0.213600684
Score:  0.181
Data Source:  BioPlex,STRINGDB
S100A3
Tbio
Novelty:  0.03024004
Score:  0.863
Data Source:  STRINGDB
ANXA2
Tbio
Novelty:  0.00103362
Score:  0.829
Data Source:  STRINGDB
S100B
Tchem
Novelty:  0.00031007
Score:  0.814
Data Source:  STRINGDB
S100A1
Tbio
Novelty:  0.00309618
Score:  0.794
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.794
Data Source:  STRINGDB
TCHHL1
Tdark
Novelty:  0.21799821
Score:  0.766
Data Source:  STRINGDB
Pathways (5)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Validated transcriptional targets of TAp63 isoforms
PathwayCommons: pid
Direct p53 effectors
PathwayCommons: pid
p73 transcription factor network
Name
Explore in Pharos
Explore in Source
Validated transcriptional targets of TAp63 isoforms
Direct p53 effectors
p73 transcription factor network
Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
24.4
monocyte count
1
1
1
9
high density lipoprotein cholesterol measurement
1
1
1
6.9
sleep duration
1
1
1
6.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
24.4
monocyte count
1
9
high density lipoprotein cholesterol measurement
1
6.9
sleep duration
1
6.9
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A2
VGNC:53220
457321
Macaque
S100 calcium binding protein A2
715264
Dog
S100 calcium binding protein A2
VGNC:45828
612326
Horse
S100 calcium binding protein A2
VGNC:50881
100056230
Cow
S100 calcium binding protein A2
VGNC:34242
509860
Species
Name
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A2
Macaque
S100 calcium binding protein A2
Dog
S100 calcium binding protein A2
Horse
S100 calcium binding protein A2
Cow
S100 calcium binding protein A2
Publication Statistics
PubMed Score 114.01
PubMed score by year
PubTator Score 92.90
PubTator score by year