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Tbio
GJB2
Gap junction beta-2 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382844
  • ENSP00000372295
  • ENSG00000165474
  • ENST00000382848
  • ENSP00000372299
  • ENST00000645189
  • ENSP00000495035

Symbol
  • HID
  • KID
  • PPK
  • CX26
  • DFNA3
  • DFNB1
  • NSRD1
  • DFNA3A
  • DFNB1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
PubMedID
0.94
gene perturbation
0.91
phenotype
0.8
disease
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1879.34   (req: < 5)
Gene RIFs: 585   (req: <= 3)
Antibodies: 303   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1879.34   (req: >= 5)
Gene RIFs: 585   (req: > 3)
Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
gap junction protein beta 2
704224
Mouse
MGI:95720
14619
Rat
RGD:728891
394266
Dog
gap junction protein beta 2
VGNC:41238
403570
Horse
gap junction protein beta 2
VGNC:18355
100050084
Species
Name
OMA
EggNOG
Inparanoid
Macaque
gap junction protein beta 2
Mouse
Rat
Dog
gap junction protein beta 2
Horse
gap junction protein beta 2
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Gap junction assembly (R-HSA-190861)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gap junction assembly
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Membrane Trafficking
Reactome
Oligomerization of connexins into connexons
Name
Explore in Pharos
Explore in Source
Gap junction assembly
Gap junction trafficking
Gap junction trafficking and regulation
Membrane Trafficking
Oligomerization of connexins into connexons
Gene Ontology Terms (28)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (103)
1 – 10 of 103
GJB1
Tbio
Novelty: 0.00109019
Score: 0.938
Data Source: Reactome,STRINGDB
SLC26A4
Tbio
Family: Transporter
Novelty: 0.00162006
Score: 0.899
Data Source: STRINGDB
PANX1
Tbio
Family: IC
Novelty: 0.00159814
Score: 0.78
Data Source: STRINGDB
PANX2
Tbio
Family: IC
Novelty: 0.00620748
Score: 0.774
Data Source: STRINGDB
PANX3
Tbio
Family: IC
Novelty: 0.0071997
Score: 0.753
Data Source: STRINGDB
TMIE
Tbio
Novelty: 0.02939225
Score: 0.747
Data Source: STRINGDB
CNST
Tdark
Novelty: 0.10372637
Score: 0.741
Data Source: STRINGDB
TMC1
Tbio
Family: IC
Novelty: 0.00609628
Score: 0.741
Data Source: STRINGDB
GJA8
Tbio
Novelty: 0.00377739
Score: 0.74
Data Source: STRINGDB
OTOF
Tbio
Novelty: 0.00676341
Score: 0.739
Data Source: STRINGDB
Publication Statistics
PubMed Score  1879.34

PubMed score by year
PubTator Score  1487.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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